Pulmonary Function Abnormalities in Nigerian Children with Sickle Cell Anaemia: Prevalence, Pattern and Predictive Factors
Background: Advances in care of children with sickle cell anaemia (SCA) have increased their chances of survival to adolescence and adulthood though this is often associated with multi-organ system pathologies including lung dysfunctions. This study aimed to determine the prevalence, pattern and fac...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-10-01
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| Series: | Pediatric Respirology and Critical Care Medicine |
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| Online Access: | https://journals.lww.com/10.4103/prcm.prcm_13_18 |
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| _version_ | 1849714784874790912 |
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| author | Bankole Peter Kuti Samuel Ademola Adegoke |
| author_facet | Bankole Peter Kuti Samuel Ademola Adegoke |
| author_sort | Bankole Peter Kuti |
| collection | DOAJ |
| description | Background:
Advances in care of children with sickle cell anaemia (SCA) have increased their chances of survival to adolescence and adulthood though this is often associated with multi-organ system pathologies including lung dysfunctions. This study aimed to determine the prevalence, pattern and factors associated with pulmonary function abnormalities in Nigerian children with SCA.
Methods:
Pulmonary functions of 104 children with SCA in steady state and 104 age- and sex-matched haemoglobin AA controls aged 6 to 16 years at the Wesley Guild Hospital, Ilesa Nigeria, were assessed using Spirolab III (Medical International Research, Italy) spirometer following standard protocol. Socio-demographic characteristics, nutritional status and pulmonary function parameters of these children were compared, and the predictive factors of pulmonary function abnormalities in SCA children were determined using binary logistic regression.
Results:
SCA children had lower lung volumes and capacities and higher prevalence of pulmonary function abnormalities compared to controls, and a restrictive ventilatory pattern (22.1%) was the most predominant form. Adolescent age, previous acute chest syndrome (ACS), repeated painful crises and multiple hospitalisations in the previous year were significantly associated with pulmonary function abnormalities (P < 0.05). Only adolescent age group (odds ratio [OR] = 3.738; 95% confidence interval [CI] = 1.480–9.440; P = 0.005) and previous ACS (OR = 8.500; 95% CI = 2.044–12.959; P = 0.044) independently predicted pulmonary function impairments among the SCA children.
Conclusion:
SCA predisposes children to pulmonary dysfunction, particularly during adolescent years and in those with ACS, multiple crises and hospitalisations. Routine pulmonary function assessment in these children will facilitate early recognition and prompt management. |
| format | Article |
| id | doaj-art-01a0f668b8ec4be586d93e0ea8723889 |
| institution | DOAJ |
| issn | 2543-0343 2543-0351 |
| language | English |
| publishDate | 2018-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Pediatric Respirology and Critical Care Medicine |
| spelling | doaj-art-01a0f668b8ec4be586d93e0ea87238892025-08-20T03:13:36ZengWolters Kluwer Medknow PublicationsPediatric Respirology and Critical Care Medicine2543-03432543-03512018-10-0124737910.4103/prcm.prcm_13_18Pulmonary Function Abnormalities in Nigerian Children with Sickle Cell Anaemia: Prevalence, Pattern and Predictive FactorsBankole Peter KutiSamuel Ademola AdegokeBackground: Advances in care of children with sickle cell anaemia (SCA) have increased their chances of survival to adolescence and adulthood though this is often associated with multi-organ system pathologies including lung dysfunctions. This study aimed to determine the prevalence, pattern and factors associated with pulmonary function abnormalities in Nigerian children with SCA. Methods: Pulmonary functions of 104 children with SCA in steady state and 104 age- and sex-matched haemoglobin AA controls aged 6 to 16 years at the Wesley Guild Hospital, Ilesa Nigeria, were assessed using Spirolab III (Medical International Research, Italy) spirometer following standard protocol. Socio-demographic characteristics, nutritional status and pulmonary function parameters of these children were compared, and the predictive factors of pulmonary function abnormalities in SCA children were determined using binary logistic regression. Results: SCA children had lower lung volumes and capacities and higher prevalence of pulmonary function abnormalities compared to controls, and a restrictive ventilatory pattern (22.1%) was the most predominant form. Adolescent age, previous acute chest syndrome (ACS), repeated painful crises and multiple hospitalisations in the previous year were significantly associated with pulmonary function abnormalities (P < 0.05). Only adolescent age group (odds ratio [OR] = 3.738; 95% confidence interval [CI] = 1.480–9.440; P = 0.005) and previous ACS (OR = 8.500; 95% CI = 2.044–12.959; P = 0.044) independently predicted pulmonary function impairments among the SCA children. Conclusion: SCA predisposes children to pulmonary dysfunction, particularly during adolescent years and in those with ACS, multiple crises and hospitalisations. Routine pulmonary function assessment in these children will facilitate early recognition and prompt management.https://journals.lww.com/10.4103/prcm.prcm_13_18acute chest syndromepainful crisispulmonary functionsickle cell anaemia |
| spellingShingle | Bankole Peter Kuti Samuel Ademola Adegoke Pulmonary Function Abnormalities in Nigerian Children with Sickle Cell Anaemia: Prevalence, Pattern and Predictive Factors Pediatric Respirology and Critical Care Medicine acute chest syndrome painful crisis pulmonary function sickle cell anaemia |
| title | Pulmonary Function Abnormalities in Nigerian Children with Sickle Cell Anaemia: Prevalence, Pattern and Predictive Factors |
| title_full | Pulmonary Function Abnormalities in Nigerian Children with Sickle Cell Anaemia: Prevalence, Pattern and Predictive Factors |
| title_fullStr | Pulmonary Function Abnormalities in Nigerian Children with Sickle Cell Anaemia: Prevalence, Pattern and Predictive Factors |
| title_full_unstemmed | Pulmonary Function Abnormalities in Nigerian Children with Sickle Cell Anaemia: Prevalence, Pattern and Predictive Factors |
| title_short | Pulmonary Function Abnormalities in Nigerian Children with Sickle Cell Anaemia: Prevalence, Pattern and Predictive Factors |
| title_sort | pulmonary function abnormalities in nigerian children with sickle cell anaemia prevalence pattern and predictive factors |
| topic | acute chest syndrome painful crisis pulmonary function sickle cell anaemia |
| url | https://journals.lww.com/10.4103/prcm.prcm_13_18 |
| work_keys_str_mv | AT bankolepeterkuti pulmonaryfunctionabnormalitiesinnigerianchildrenwithsicklecellanaemiaprevalencepatternandpredictivefactors AT samuelademolaadegoke pulmonaryfunctionabnormalitiesinnigerianchildrenwithsicklecellanaemiaprevalencepatternandpredictivefactors |