Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorderResearch in context

Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorderResearch in context

Summary: Background: Synucleinopathies include a spectrum of disorders varying in features and severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB). Distinct brain atrophy patterns may already be seen in iRBD...

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Main Authors: Stephen Joza, Aline Delva, Christina Tremblay, Andrew Vo, Marie Filiatrault, Max Tweedale, Jean-François Gagnon, Ronald B. Postuma, Alain Dagher, Johannes Klein, Michele Hu, Petr Dusek, Stanislav Marecek, Zsoka Varga, John-Paul Taylor, John T. O'Brien, Michael Firbank, Alan Thomas, Paul C. Donaghy, Stéphane Lehéricy, Marie Vidailhet, Jean-Christophe Corvol, ICEBERG Study Group, Richard Camicioli, Howard Chertkow, Simon Lewis, Elie Matar, Kaylena A. Ehgoetz Martens, Lachlan Churchill, Michael Sommerauer, Sinah Röttgen, Per Borghammer, Karoline Knudsen, Allan K. Hansen, Dario Arnaldi, Beatrice Orso, Pietro Mattioli, Luca Roccatagliata, Oury Monchi, Shady Rahayel, Isabelle Arnulf, Samir Bekadar, Eve Benchetrit, Alexis Brice, Vanessa Brochard, Alizé Chalançon, Benoit Colsch, Florence Cormier-Dequaire, Virginie Czernecki, Bertrand Degos, Cécile Delorme, Pauline Dodet, Carole Dongmo-Kenfack, Marie-Odile Habert, Farid Ichou, Jonas Ihle, Cécile Galléa, Rahul Gaurav, Marie-Alexandrine Glachant, Manon Gomes, David Grabli, Elodie Hainque, Laetitia Jeancolas, Christelle Laganot, Suzanne Lesage, Smaranda Leu-Semenescu, Richard Levy, Valentine Maheo, Graziella Mangone, Louise Laure Mariani, Aurelie Méneret, Poornima Menon, Fanny Mochel, Vincent Perlbarg, Dijana Petrovska, Fanny Pineau, Nadya Pyatigorskaya, Sophie Rivaud-Pechoux, Emmanuel Roze, Sara Sambin, Julie Socha, Arthur Tenenhaus, Romain Valabregue, Lydia Yahia-Cherif
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:EBioMedicine
Subjects:
REM sleep behaviour disorder
Parkinson's disease
Dementia with Lewy bodies
MRI
Subtyping
Machine learning
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425001975
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