Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorderResearch in context
Summary: Background: Synucleinopathies include a spectrum of disorders varying in features and severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB). Distinct brain atrophy patterns may already be seen in iRBD...
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| author | Stephen Joza Aline Delva Christina Tremblay Andrew Vo Marie Filiatrault Max Tweedale Jean-François Gagnon Ronald B. Postuma Alain Dagher Johannes Klein Michele Hu Petr Dusek Stanislav Marecek Zsoka Varga John-Paul Taylor John T. O'Brien Michael Firbank Alan Thomas Paul C. Donaghy Stéphane Lehéricy Marie Vidailhet Jean-Christophe Corvol ICEBERG Study Group Richard Camicioli Howard Chertkow Simon Lewis Elie Matar Kaylena A. Ehgoetz Martens Lachlan Churchill Michael Sommerauer Sinah Röttgen Per Borghammer Karoline Knudsen Allan K. Hansen Dario Arnaldi Beatrice Orso Pietro Mattioli Luca Roccatagliata Oury Monchi Shady Rahayel Isabelle Arnulf Samir Bekadar Eve Benchetrit Alexis Brice Vanessa Brochard Alizé Chalançon Benoit Colsch Florence Cormier-Dequaire Jean-Christophe Corvol Virginie Czernecki Bertrand Degos Cécile Delorme Pauline Dodet Carole Dongmo-Kenfack Marie-Odile Habert Farid Ichou Jonas Ihle Cécile Galléa Rahul Gaurav Marie-Alexandrine Glachant Manon Gomes David Grabli Elodie Hainque Laetitia Jeancolas Christelle Laganot Stéphane Lehéricy Suzanne Lesage Smaranda Leu-Semenescu Richard Levy Valentine Maheo Graziella Mangone Louise Laure Mariani Aurelie Méneret Poornima Menon Fanny Mochel Vincent Perlbarg Dijana Petrovska Fanny Pineau Nadya Pyatigorskaya Sophie Rivaud-Pechoux Emmanuel Roze Sara Sambin Julie Socha Arthur Tenenhaus Romain Valabregue Marie Vidailhet Lydia Yahia-Cherif |
| author_facet | Stephen Joza Aline Delva Christina Tremblay Andrew Vo Marie Filiatrault Max Tweedale Jean-François Gagnon Ronald B. Postuma Alain Dagher Johannes Klein Michele Hu Petr Dusek Stanislav Marecek Zsoka Varga John-Paul Taylor John T. O'Brien Michael Firbank Alan Thomas Paul C. Donaghy Stéphane Lehéricy Marie Vidailhet Jean-Christophe Corvol ICEBERG Study Group Richard Camicioli Howard Chertkow Simon Lewis Elie Matar Kaylena A. Ehgoetz Martens Lachlan Churchill Michael Sommerauer Sinah Röttgen Per Borghammer Karoline Knudsen Allan K. Hansen Dario Arnaldi Beatrice Orso Pietro Mattioli Luca Roccatagliata Oury Monchi Shady Rahayel Isabelle Arnulf Samir Bekadar Eve Benchetrit Alexis Brice Vanessa Brochard Alizé Chalançon Benoit Colsch Florence Cormier-Dequaire Jean-Christophe Corvol Virginie Czernecki Bertrand Degos Cécile Delorme Pauline Dodet Carole Dongmo-Kenfack Marie-Odile Habert Farid Ichou Jonas Ihle Cécile Galléa Rahul Gaurav Marie-Alexandrine Glachant Manon Gomes David Grabli Elodie Hainque Laetitia Jeancolas Christelle Laganot Stéphane Lehéricy Suzanne Lesage Smaranda Leu-Semenescu Richard Levy Valentine Maheo Graziella Mangone Louise Laure Mariani Aurelie Méneret Poornima Menon Fanny Mochel Vincent Perlbarg Dijana Petrovska Fanny Pineau Nadya Pyatigorskaya Sophie Rivaud-Pechoux Emmanuel Roze Sara Sambin Julie Socha Arthur Tenenhaus Romain Valabregue Marie Vidailhet Lydia Yahia-Cherif |
| author_sort | Stephen Joza |
| collection | DOAJ |
| description | Summary: Background: Synucleinopathies include a spectrum of disorders varying in features and severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB). Distinct brain atrophy patterns may already be seen in iRBD; however, how brain atrophy begins and progresses remains unclear. Methods: A multicentric cohort of 1276 participants (451 polysomnography-confirmed iRBD, 142 PD with probable RBD, 87 DLB, and 596 controls) underwent T1-weighted MRI and longitudinal clinical assessments. Brain atrophy was quantified using vertex-based cortical surface reconstruction and volumetric segmentation. The unsupervised machine learning algorithm, Subtype and Stage Inference (SuStaIn), was used to reconstruct spatiotemporal patterns of brain atrophy progression. Findings: SuStaIn identified two distinct subtypes of brain atrophy progression: 1) a “cortical-first” subtype, with atrophy beginning in the frontal lobes and involving the subcortical structures at later stages; and 2) a “subcortical-first” subtype, with atrophy beginning in the limbic areas and involving cortical structures at later stages. Both cortical- and subcortical-first subtypes were associated with a higher rate of increase in MDS-UPDRS-III scores over time, but cognitive decline was subtype-specific, being associated with advancing stages in patients classified as cortical-first but not subcortical-first. Classified patients were more likely to phenoconvert over time compared to stage 0/non-classified patients. Among the 88 patients with iRBD who phenoconverted during follow-up, those classified within the cortical-first subtype had a significantly increased likelihood of developing DLB compared to PD, unlike those classified within the subcortical-first subtype. Interpretation: There are two distinct atrophy progression subtypes in iRBD, with the cortical-first subtype linked to an increased likelihood of developing DLB, while both subtypes were associated with worsening parkinsonian motor features. This underscores the potential utility of subtype identification and staging for monitoring disease progression and patient selection for trials. Funding: This study was supported by grants to S.R. from Alzheimer Society Canada (0000000082) and by Parkinson Canada (PPG-2023-0000000122).The work performed in Montreal was supported by the Canadian Institutes of Health Research (CIHR), the Fonds de recherche du Québec - Santé (FRQS), and the W. Garfield Weston Foundation.The work performed in Oxford was funded by Parkinson's UK (J-2101) and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC).The work performed in Prague was funded by the Czech Health Research Council (grant NU21-04-00535) and by The National Institute for Neurological Research (project number LX22NPO5107), financed by the European Union – Next Generation EU. The work performed in Newcastle was funded by the NIHR Newcastle BRC based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University.The work performed in Paris was funded by grants from the Programme d'investissements d'avenir (ANR-10-IAIHU-06), the Paris Institute of Neurosciences – IHU (IAIHU-06), the Agence Nationale de la Recherche (ANR-11-INBS-0006), Électricité de France (Fondation d’Entreprise EDF), the EU Joint Programme–Neurodegenerative Disease Research (JPND) for the Control-PD Project (Cognitive Propagation in Prodromal Parkinson's disease), the Fondation Thérèse et René Planiol, the Fonds Saint-Michel; by unrestricted support for research on Parkinson's disease from Energipole (M. Mallart) and the Société Française de Médecine Esthétique (M. Legrand); and by a grant from the Institut de France to Isabelle Arnulf (for the ALICE Study).The work performed in Sydney was supported by a Dementia Team Grant from the National Health and Medical Research Council (#1095127).The work performed in Cologne was funded by the Else Kröner-Fresenius-Stiftung (grant number 2019_EKES.02), the Köln Fortune Program, Faculty of Medicine, University of Cologne, and the “Netzwerke 2021 Program (Ministry of Culture and Science of Northrhine Westphalia State).The work performed in Aarhus was supported by funding from the Lundbeck Foundation, Parkinsonforeningen (The Danish Parkinson Association), and the Jascha Foundation. |
| format | Article |
| id | doaj-art-01a0f2ffceba4d7192abffb2ab55a15a |
| institution | DOAJ |
| issn | 2352-3964 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj-art-01a0f2ffceba4d7192abffb2ab55a15a2025-08-20T03:10:18ZengElsevierEBioMedicine2352-39642025-07-0111710575310.1016/j.ebiom.2025.105753Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorderResearch in contextStephen Joza0Aline Delva1Christina Tremblay2Andrew Vo3Marie Filiatrault4Max Tweedale5Jean-François Gagnon6Ronald B. Postuma7Alain Dagher8Johannes Klein9Michele Hu10Petr Dusek11Stanislav Marecek12Zsoka Varga13John-Paul Taylor14John T. O'Brien15Michael Firbank16Alan Thomas17Paul C. Donaghy18Stéphane Lehéricy19Marie Vidailhet20Jean-Christophe Corvol21 ICEBERG Study Group22Richard Camicioli23Howard Chertkow24Simon Lewis25Elie Matar26Kaylena A. Ehgoetz Martens27Lachlan Churchill28Michael Sommerauer29Sinah Röttgen30Per Borghammer31Karoline Knudsen32Allan K. Hansen33Dario Arnaldi34Beatrice Orso35Pietro Mattioli36Luca Roccatagliata37Oury Monchi38Shady Rahayel39Isabelle ArnulfSamir BekadarEve BenchetritAlexis BriceVanessa BrochardAlizé ChalançonBenoit ColschFlorence Cormier-DequaireJean-Christophe CorvolVirginie CzerneckiBertrand DegosCécile DelormePauline DodetCarole Dongmo-KenfackMarie-Odile HabertFarid IchouJonas IhleCécile GalléaRahul GauravMarie-Alexandrine GlachantManon GomesDavid GrabliElodie HainqueLaetitia JeancolasChristelle LaganotStéphane LehéricySuzanne LesageSmaranda Leu-SemenescuRichard LevyValentine MaheoGraziella MangoneLouise Laure MarianiAurelie MéneretPoornima MenonFanny MochelVincent PerlbargDijana PetrovskaFanny PineauNadya PyatigorskayaSophie Rivaud-PechouxEmmanuel RozeSara SambinJulie SochaArthur TenenhausRomain ValabregueMarie VidailhetLydia Yahia-CherifThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, Canada; Division of Neurology, Department of Medicine, and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, CanadaThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, CanadaThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, Canada; Centre for Advanced Research in Sleep Medicine, CIUSSS-NÎM – Hôpital du Sacré-Cœur de Montréal, Montreal, H4J 1C5, CanadaThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, CanadaCentre for Advanced Research in Sleep Medicine, CIUSSS-NÎM – Hôpital du Sacré-Cœur de Montréal, Montreal, H4J 1C5, CanadaThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, CanadaCentre for Advanced Research in Sleep Medicine, CIUSSS-NÎM – Hôpital du Sacré-Cœur de Montréal, Montreal, H4J 1C5, Canada; Department of Psychology, Université du Québec à Montréal, Montreal, H2X 3P2, Canada; Research Centre, Institut universitaire de gériatrie de Montréal, Montreal, H3W 1W5, CanadaThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, Canada; Centre for Advanced Research in Sleep Medicine, CIUSSS-NÎM – Hôpital du Sacré-Cœur de Montréal, Montreal, H4J 1C5, Canada; Department of Neurology, Montreal General Hospital, Montreal, H3G 1A4, CanadaThe Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, CanadaOxford Parkinson's Disease Centre and Division of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UKOxford Parkinson's Disease Centre and Division of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UKDepartment of Neurology and Centre of Clinical Neurosciences, First Faculty of Medicine, Charles University and General University Hospital, Prague, CzechiaDepartment of Neurology and Centre of Clinical Neurosciences, First Faculty of Medicine, Charles University and General University Hospital, Prague, CzechiaDepartment of Neurology and Centre of Clinical Neurosciences, First Faculty of Medicine, Charles University and General University Hospital, Prague, CzechiaTranslational and Clinical Research Institute, Newcastle University, Newcastle, UKDepartment of Psychiatry, University of Cambridge School of Clinical Medicine, Cambridge, UKTranslational and Clinical Research Institute, Newcastle University, Newcastle, UKTranslational and Clinical Research Institute, Newcastle University, Newcastle, UKTranslational and Clinical Research Institute, Newcastle University, Newcastle, UKInstitut du Cerveau – Paris Brain Institute – ICM, Sorbonne Université, INSERM UMR 1127, CNRS 7225, Clinical Investigation Centre (CIC), Paris, 75013, FranceInstitut du Cerveau – Paris Brain Institute – ICM, Sorbonne Université, INSERM UMR 1127, CNRS 7225, Clinical Investigation Centre (CIC), Paris, 75013, FranceInstitut du Cerveau – Paris Brain Institute – ICM, Sorbonne Université, INSERM UMR 1127, CNRS 7225, Clinical Investigation Centre (CIC), Paris, 75013, FranceInstitut du Cerveau – Paris Brain Institute – ICM, Sorbonne Université, INSERM UMR 1127, CNRS 7225, Clinical Investigation Centre (CIC), Paris, 75013, FranceDivision of Neurology, Department of Medicine, and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, CanadaDepartment of Medicine (Neurology), University of Toronto, Toronto, Ontario, Canada; Rotman Research Institute, Baycrest Health Services, Toronto, Ontario, CanadaParkinson's Disease Research Clinic, Macquarie Medical School, Macquarie University, Sydney, Australia; Parkinson's Disease Research Clinic, Brain and Mind Centre, University of Sydney, Camperdown, NSW, 2050, AustraliaParkinson's Disease Research Clinic, Macquarie Medical School, Macquarie University, Sydney, AustraliaParkinson's Disease Research Clinic, Macquarie Medical School, Macquarie University, Sydney, Australia; Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, N2L 3G1, CanadaParkinson's Disease Research Clinic, Macquarie Medical School, Macquarie University, Sydney, AustraliaCentre of Neurology, Department of Parkinson, Sleep and Movement Disorders, University Hospital Bonn, Bonn, Germany; German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Neurology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Forschungszentrum Jülich, Jülich, GermanyDepartment of Neurology, University Hospital Cologne, Faculty of Medicine, University of Cologne, Cologne, Germany; Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Forschungszentrum Jülich, Jülich, GermanyDepartment of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, DK-8200, DenmarkDepartment of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, DK-8200, DenmarkDepartment of Nuclear Medicine and PET, Aarhus University Hospital, Aarhus, DK-8200, DenmarkDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Genoa, 16132, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, 16132, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Genoa, 16132, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Genoa, 16132, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, 16132, ItalyDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Clinical Neurology, University of Genoa, Genoa, 16132, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, 16132, ItalyResearch Centre, Institut universitaire de gériatrie de Montréal, Montreal, H3W 1W5, Canada; Department of Radiology, Radio-Oncology, and Nuclear Medicine, University of Montreal, Montreal, H3T 1A4, CanadaCentre for Advanced Research in Sleep Medicine, CIUSSS-NÎM – Hôpital du Sacré-Cœur de Montréal, Montreal, H4J 1C5, Canada; Department of Medicine, University of Montreal, Montreal, H3T 1A4, Canada; Corresponding author. Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré-Cœur de Montréal, 5400 West Gouin Boulevard, Montreal, Quebec, H4J 1C5, Canada.Summary: Background: Synucleinopathies include a spectrum of disorders varying in features and severity, including idiopathic/isolated REM sleep behaviour disorder (iRBD), Parkinson's disease (PD), and dementia with Lewy bodies (DLB). Distinct brain atrophy patterns may already be seen in iRBD; however, how brain atrophy begins and progresses remains unclear. Methods: A multicentric cohort of 1276 participants (451 polysomnography-confirmed iRBD, 142 PD with probable RBD, 87 DLB, and 596 controls) underwent T1-weighted MRI and longitudinal clinical assessments. Brain atrophy was quantified using vertex-based cortical surface reconstruction and volumetric segmentation. The unsupervised machine learning algorithm, Subtype and Stage Inference (SuStaIn), was used to reconstruct spatiotemporal patterns of brain atrophy progression. Findings: SuStaIn identified two distinct subtypes of brain atrophy progression: 1) a “cortical-first” subtype, with atrophy beginning in the frontal lobes and involving the subcortical structures at later stages; and 2) a “subcortical-first” subtype, with atrophy beginning in the limbic areas and involving cortical structures at later stages. Both cortical- and subcortical-first subtypes were associated with a higher rate of increase in MDS-UPDRS-III scores over time, but cognitive decline was subtype-specific, being associated with advancing stages in patients classified as cortical-first but not subcortical-first. Classified patients were more likely to phenoconvert over time compared to stage 0/non-classified patients. Among the 88 patients with iRBD who phenoconverted during follow-up, those classified within the cortical-first subtype had a significantly increased likelihood of developing DLB compared to PD, unlike those classified within the subcortical-first subtype. Interpretation: There are two distinct atrophy progression subtypes in iRBD, with the cortical-first subtype linked to an increased likelihood of developing DLB, while both subtypes were associated with worsening parkinsonian motor features. This underscores the potential utility of subtype identification and staging for monitoring disease progression and patient selection for trials. Funding: This study was supported by grants to S.R. from Alzheimer Society Canada (0000000082) and by Parkinson Canada (PPG-2023-0000000122).The work performed in Montreal was supported by the Canadian Institutes of Health Research (CIHR), the Fonds de recherche du Québec - Santé (FRQS), and the W. Garfield Weston Foundation.The work performed in Oxford was funded by Parkinson's UK (J-2101) and the National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC).The work performed in Prague was funded by the Czech Health Research Council (grant NU21-04-00535) and by The National Institute for Neurological Research (project number LX22NPO5107), financed by the European Union – Next Generation EU. The work performed in Newcastle was funded by the NIHR Newcastle BRC based at Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University.The work performed in Paris was funded by grants from the Programme d'investissements d'avenir (ANR-10-IAIHU-06), the Paris Institute of Neurosciences – IHU (IAIHU-06), the Agence Nationale de la Recherche (ANR-11-INBS-0006), Électricité de France (Fondation d’Entreprise EDF), the EU Joint Programme–Neurodegenerative Disease Research (JPND) for the Control-PD Project (Cognitive Propagation in Prodromal Parkinson's disease), the Fondation Thérèse et René Planiol, the Fonds Saint-Michel; by unrestricted support for research on Parkinson's disease from Energipole (M. Mallart) and the Société Française de Médecine Esthétique (M. Legrand); and by a grant from the Institut de France to Isabelle Arnulf (for the ALICE Study).The work performed in Sydney was supported by a Dementia Team Grant from the National Health and Medical Research Council (#1095127).The work performed in Cologne was funded by the Else Kröner-Fresenius-Stiftung (grant number 2019_EKES.02), the Köln Fortune Program, Faculty of Medicine, University of Cologne, and the “Netzwerke 2021 Program (Ministry of Culture and Science of Northrhine Westphalia State).The work performed in Aarhus was supported by funding from the Lundbeck Foundation, Parkinsonforeningen (The Danish Parkinson Association), and the Jascha Foundation.http://www.sciencedirect.com/science/article/pii/S2352396425001975REM sleep behaviour disorderParkinson's diseaseDementia with Lewy bodiesMRISubtypingMachine learning |
| spellingShingle | Stephen Joza Aline Delva Christina Tremblay Andrew Vo Marie Filiatrault Max Tweedale Jean-François Gagnon Ronald B. Postuma Alain Dagher Johannes Klein Michele Hu Petr Dusek Stanislav Marecek Zsoka Varga John-Paul Taylor John T. O'Brien Michael Firbank Alan Thomas Paul C. Donaghy Stéphane Lehéricy Marie Vidailhet Jean-Christophe Corvol ICEBERG Study Group Richard Camicioli Howard Chertkow Simon Lewis Elie Matar Kaylena A. Ehgoetz Martens Lachlan Churchill Michael Sommerauer Sinah Röttgen Per Borghammer Karoline Knudsen Allan K. Hansen Dario Arnaldi Beatrice Orso Pietro Mattioli Luca Roccatagliata Oury Monchi Shady Rahayel Isabelle Arnulf Samir Bekadar Eve Benchetrit Alexis Brice Vanessa Brochard Alizé Chalançon Benoit Colsch Florence Cormier-Dequaire Jean-Christophe Corvol Virginie Czernecki Bertrand Degos Cécile Delorme Pauline Dodet Carole Dongmo-Kenfack Marie-Odile Habert Farid Ichou Jonas Ihle Cécile Galléa Rahul Gaurav Marie-Alexandrine Glachant Manon Gomes David Grabli Elodie Hainque Laetitia Jeancolas Christelle Laganot Stéphane Lehéricy Suzanne Lesage Smaranda Leu-Semenescu Richard Levy Valentine Maheo Graziella Mangone Louise Laure Mariani Aurelie Méneret Poornima Menon Fanny Mochel Vincent Perlbarg Dijana Petrovska Fanny Pineau Nadya Pyatigorskaya Sophie Rivaud-Pechoux Emmanuel Roze Sara Sambin Julie Socha Arthur Tenenhaus Romain Valabregue Marie Vidailhet Lydia Yahia-Cherif Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorderResearch in context EBioMedicine REM sleep behaviour disorder Parkinson's disease Dementia with Lewy bodies MRI Subtyping Machine learning |
| title | Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorderResearch in context |
| title_full | Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorderResearch in context |
| title_fullStr | Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorderResearch in context |
| title_full_unstemmed | Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorderResearch in context |
| title_short | Distinct brain atrophy progression subtypes underlie phenoconversion in isolated REM sleep behaviour disorderResearch in context |
| title_sort | distinct brain atrophy progression subtypes underlie phenoconversion in isolated rem sleep behaviour disorderresearch in context |
| topic | REM sleep behaviour disorder Parkinson's disease Dementia with Lewy bodies MRI Subtyping Machine learning |
| url | http://www.sciencedirect.com/science/article/pii/S2352396425001975 |
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distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT bertranddegos distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT ceciledelorme distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT paulinedodet distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT caroledongmokenfack distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT marieodilehabert distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT faridichou distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT jonasihle distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT cecilegallea distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT rahulgaurav distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT mariealexandrineglachant distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT manongomes distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT davidgrabli distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT elodiehainque distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT laetitiajeancolas distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT christellelaganot distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT stephanelehericy distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT suzannelesage distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT smarandaleusemenescu distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT richardlevy distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT valentinemaheo distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT graziellamangone distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT louiselauremariani distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT aureliemeneret distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT poornimamenon distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT fannymochel distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT vincentperlbarg distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT dijanapetrovska distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT fannypineau distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT nadyapyatigorskaya distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT sophierivaudpechoux distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT emmanuelroze distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT sarasambin distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT juliesocha distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT arthurtenenhaus distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT romainvalabregue distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT marievidailhet distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext AT lydiayahiacherif distinctbrainatrophyprogressionsubtypesunderliephenoconversioninisolatedremsleepbehaviourdisorderresearchincontext |