Identification of Grape <i>NRT</i> Gene Family and Analysis of Its Expression in Leaves Under Nitrogen-Deficiency Stress

Nitrogen, an indispensable macronutrient, significantly affects the appearance, quality, and yield of grapes (<i>Vitis vinifera</i>). Adequate nitrate uptake and intracellular transport, facilitated primarily by nitrate transport (NRT) proteins, are crucial for maintaining nutritional ba...

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Main Authors: Zhongyi Yang, Junjie Mei, Wei Zheng, Falak Sher Khan, Mohammad Nasim Bhuiyan, Kangjie Wang, Mohammad Saidur Rhaman, Naomi Abe-Kanoh, Wei Ji
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Horticulturae
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Online Access:https://www.mdpi.com/2311-7524/11/3/252
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author Zhongyi Yang
Junjie Mei
Wei Zheng
Falak Sher Khan
Mohammad Nasim Bhuiyan
Kangjie Wang
Mohammad Saidur Rhaman
Naomi Abe-Kanoh
Wei Ji
author_facet Zhongyi Yang
Junjie Mei
Wei Zheng
Falak Sher Khan
Mohammad Nasim Bhuiyan
Kangjie Wang
Mohammad Saidur Rhaman
Naomi Abe-Kanoh
Wei Ji
author_sort Zhongyi Yang
collection DOAJ
description Nitrogen, an indispensable macronutrient, significantly affects the appearance, quality, and yield of grapes (<i>Vitis vinifera</i>). Adequate nitrate uptake and intracellular transport, facilitated primarily by nitrate transport (NRT) proteins, are crucial for maintaining nutritional balance. However, there are no reports on the <i>NRT</i> gene family in grapes. In this study, we identified 53 <i>Nitrate Transporter 1/Peptide Transporter Family</i> (<i>NPF</i>), 3 <i>nitrate transporter 2 family</i> (<i>NRT2</i>), and 1 <i>Nitrate Assimilation-Related 2</i> (<i>NAR2</i>) genes in the grapevine Pinot Noir PN40024 genome. A comprehensive analysis of these gene families, including their physicochemical properties, structural organization, chromosomal distribution, collinearity, cis-acting element distribution, and phylogenetic relationships, revealed the rich diversity and evolutionary conservation of the grapevine <i>Nitrate Transporter</i> (<i>NRT</i>) <i>genes</i>. Furthermore, the expression profiles of <i>VvNRTs</i> in different tissues demonstrated that the <i>NRT</i> genes possess spatio-temporal expression specificity. The expression patterns of the <i>NRT</i> genes were examined by transcriptome sequencing in grapevines across various tissues under nitrogen-deficiency conditions. The expression patterns in grapevine leaves under nitrogen-deficiency conditions showed upregulation of the <i>VvNPF2.3</i> gene in conditions of nitrogen deficiency. This upregulation was strongly associated with a 62.2% reduction in indole-3-acetic acid (IAA) levels and a 21.3% increase in hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) levels, suggesting a complex regulatory response to nitrogen-induced stress. These findings emphasize the potential involvement of <i>NRT</i> genes in the adaptive reaction to nitrogen deficiency and set the stage for future investigations into the molecular mechanisms of nitrogen transportation in grapevines.
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spelling doaj-art-01a0f228cc6e49fca10e57f8f88062012025-08-20T02:42:32ZengMDPI AGHorticulturae2311-75242025-02-0111325210.3390/horticulturae11030252Identification of Grape <i>NRT</i> Gene Family and Analysis of Its Expression in Leaves Under Nitrogen-Deficiency StressZhongyi Yang0Junjie Mei1Wei Zheng2Falak Sher Khan3Mohammad Nasim Bhuiyan4Kangjie Wang5Mohammad Saidur Rhaman6Naomi Abe-Kanoh7Wei Ji8College of Horticulture, Shanxi Agricultural University, Jinzhong 030801, ChinaCollege of Horticulture, Shanxi Agricultural University, Jinzhong 030801, ChinaCollege of Horticulture, Shanxi Agricultural University, Jinzhong 030801, ChinaState Key Laboratory of Wheat Improvement, College of Life Sciences Shandong Agricultural University, Taian 271018, ChinaState Key Laboratory of Wheat Improvement, College of Life Sciences Shandong Agricultural University, Taian 271018, ChinaShanxi Yuncheng Agricultural Vocational and Technical College, Yunchen 044000, ChinaDepartment of Seed Science and Technology, Bangladesh Agricultural University, Mymensingh 2202, BangladeshDepartment of Food, Life and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka 997-8555, JapanCollege of Horticulture, Shanxi Agricultural University, Jinzhong 030801, ChinaNitrogen, an indispensable macronutrient, significantly affects the appearance, quality, and yield of grapes (<i>Vitis vinifera</i>). Adequate nitrate uptake and intracellular transport, facilitated primarily by nitrate transport (NRT) proteins, are crucial for maintaining nutritional balance. However, there are no reports on the <i>NRT</i> gene family in grapes. In this study, we identified 53 <i>Nitrate Transporter 1/Peptide Transporter Family</i> (<i>NPF</i>), 3 <i>nitrate transporter 2 family</i> (<i>NRT2</i>), and 1 <i>Nitrate Assimilation-Related 2</i> (<i>NAR2</i>) genes in the grapevine Pinot Noir PN40024 genome. A comprehensive analysis of these gene families, including their physicochemical properties, structural organization, chromosomal distribution, collinearity, cis-acting element distribution, and phylogenetic relationships, revealed the rich diversity and evolutionary conservation of the grapevine <i>Nitrate Transporter</i> (<i>NRT</i>) <i>genes</i>. Furthermore, the expression profiles of <i>VvNRTs</i> in different tissues demonstrated that the <i>NRT</i> genes possess spatio-temporal expression specificity. The expression patterns of the <i>NRT</i> genes were examined by transcriptome sequencing in grapevines across various tissues under nitrogen-deficiency conditions. The expression patterns in grapevine leaves under nitrogen-deficiency conditions showed upregulation of the <i>VvNPF2.3</i> gene in conditions of nitrogen deficiency. This upregulation was strongly associated with a 62.2% reduction in indole-3-acetic acid (IAA) levels and a 21.3% increase in hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) levels, suggesting a complex regulatory response to nitrogen-induced stress. These findings emphasize the potential involvement of <i>NRT</i> genes in the adaptive reaction to nitrogen deficiency and set the stage for future investigations into the molecular mechanisms of nitrogen transportation in grapevines.https://www.mdpi.com/2311-7524/11/3/252grapevinesnitrate transporterphylogenetic evolutionexpression analysisabiotic stress
spellingShingle Zhongyi Yang
Junjie Mei
Wei Zheng
Falak Sher Khan
Mohammad Nasim Bhuiyan
Kangjie Wang
Mohammad Saidur Rhaman
Naomi Abe-Kanoh
Wei Ji
Identification of Grape <i>NRT</i> Gene Family and Analysis of Its Expression in Leaves Under Nitrogen-Deficiency Stress
Horticulturae
grapevines
nitrate transporter
phylogenetic evolution
expression analysis
abiotic stress
title Identification of Grape <i>NRT</i> Gene Family and Analysis of Its Expression in Leaves Under Nitrogen-Deficiency Stress
title_full Identification of Grape <i>NRT</i> Gene Family and Analysis of Its Expression in Leaves Under Nitrogen-Deficiency Stress
title_fullStr Identification of Grape <i>NRT</i> Gene Family and Analysis of Its Expression in Leaves Under Nitrogen-Deficiency Stress
title_full_unstemmed Identification of Grape <i>NRT</i> Gene Family and Analysis of Its Expression in Leaves Under Nitrogen-Deficiency Stress
title_short Identification of Grape <i>NRT</i> Gene Family and Analysis of Its Expression in Leaves Under Nitrogen-Deficiency Stress
title_sort identification of grape i nrt i gene family and analysis of its expression in leaves under nitrogen deficiency stress
topic grapevines
nitrate transporter
phylogenetic evolution
expression analysis
abiotic stress
url https://www.mdpi.com/2311-7524/11/3/252
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