Chronic Myelomonocytic Leukemia Associated With TAFRO Syndrome-Like Symptoms
Thrombocytopenia, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome is a recent disease concept whose physiopathology remains largely unknown. Association of TAFRO syndrome features with immune-mediated or hematologic disorders have been reported but have not...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2024-05-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2023.1018 |
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| author | Issam Drici-Tani Lucile Grange Martin Killian Jean-Baptiste Gaultier Michel Péoc'h Manon Sapet Ludovic Fouillet Emmanuelle Tavernier-Tardy Émilie Chalayer |
| author_facet | Issam Drici-Tani Lucile Grange Martin Killian Jean-Baptiste Gaultier Michel Péoc'h Manon Sapet Ludovic Fouillet Emmanuelle Tavernier-Tardy Émilie Chalayer |
| author_sort | Issam Drici-Tani |
| collection | DOAJ |
| description | Thrombocytopenia, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome is a recent disease concept whose physiopathology remains largely unknown. Association of TAFRO syndrome features with immune-mediated or hematologic disorders have been reported but have not been reported with chronic myelomonocytic leukemia. Chronic myelomonocytic leukemia (CMML) is a myeloproliferative/myelodysplastic syndrome that is frequently associated with autoimmune or autoinflammatory features. Herein, we report 2 cases of CMML-associated TAFRO syndrome-like symptoms. The first one was fatal, and the second one was successfully treated with siltuximab. These reports question the Masaki criteria for TAFRO syndrome diagnosis, which require excluding an autoimmune, neoplastic, or infectious condition beforehand. |
| format | Article |
| id | doaj-art-019daf083033457a8502f57331da9d09 |
| institution | DOAJ |
| issn | 2767-7664 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-019daf083033457a8502f57331da9d092025-08-20T03:18:46ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642024-05-013510.7326/aimcc.2023.1018Chronic Myelomonocytic Leukemia Associated With TAFRO Syndrome-Like SymptomsIssam Drici-Tani0Lucile Grange1Martin Killian2Jean-Baptiste Gaultier3Michel Péoc'h4Manon Sapet5Ludovic Fouillet6Emmanuelle Tavernier-Tardy7Émilie Chalayer81Service de Médecine Interne, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France1Service de Médecine Interne, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France1Service de Médecine Interne, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France1Service de Médecine Interne, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France4Service d'Anatomie et Cytologie Pathologiques, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France5Département d'Hématologie et de Thérapie Cellulaire, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France5Département d'Hématologie et de Thérapie Cellulaire, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France5Département d'Hématologie et de Thérapie Cellulaire, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France3CIC EC 1408 INSERM, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, FranceThrombocytopenia, anasarca, fever, reticulin fibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome is a recent disease concept whose physiopathology remains largely unknown. Association of TAFRO syndrome features with immune-mediated or hematologic disorders have been reported but have not been reported with chronic myelomonocytic leukemia. Chronic myelomonocytic leukemia (CMML) is a myeloproliferative/myelodysplastic syndrome that is frequently associated with autoimmune or autoinflammatory features. Herein, we report 2 cases of CMML-associated TAFRO syndrome-like symptoms. The first one was fatal, and the second one was successfully treated with siltuximab. These reports question the Masaki criteria for TAFRO syndrome diagnosis, which require excluding an autoimmune, neoplastic, or infectious condition beforehand.https://www.acpjournals.org/doi/10.7326/aimcc.2023.1018 |
| spellingShingle | Issam Drici-Tani Lucile Grange Martin Killian Jean-Baptiste Gaultier Michel Péoc'h Manon Sapet Ludovic Fouillet Emmanuelle Tavernier-Tardy Émilie Chalayer Chronic Myelomonocytic Leukemia Associated With TAFRO Syndrome-Like Symptoms Annals of Internal Medicine: Clinical Cases |
| title | Chronic Myelomonocytic Leukemia Associated With TAFRO Syndrome-Like Symptoms |
| title_full | Chronic Myelomonocytic Leukemia Associated With TAFRO Syndrome-Like Symptoms |
| title_fullStr | Chronic Myelomonocytic Leukemia Associated With TAFRO Syndrome-Like Symptoms |
| title_full_unstemmed | Chronic Myelomonocytic Leukemia Associated With TAFRO Syndrome-Like Symptoms |
| title_short | Chronic Myelomonocytic Leukemia Associated With TAFRO Syndrome-Like Symptoms |
| title_sort | chronic myelomonocytic leukemia associated with tafro syndrome like symptoms |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2023.1018 |
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