Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells
Abstract Natural products have long been a viable source of therapeutic agents, providing unique structures and mechanisms that may be beneficial for cancer treatment. Herein we first report on the anticancer activity OST-01, a natural product from Baccharis Coridifolia, on breast cancer cells, incl...
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| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Hematology & Oncology |
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| Online Access: | https://doi.org/10.1186/s13045-025-01668-4 |
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| author | HyunJun Kang Dinh Hoa Hoang Melissa Valerio Khyatiben Pathak William Graff Alexis LeVee Jun Wu Mark A. LaBarge David Frankhouser Russell C. Rockne Patrick Pirrotte Bin Zhang Joanne Mortimer Le Xuan Truong Nguyen Guido Marcucci |
| author_facet | HyunJun Kang Dinh Hoa Hoang Melissa Valerio Khyatiben Pathak William Graff Alexis LeVee Jun Wu Mark A. LaBarge David Frankhouser Russell C. Rockne Patrick Pirrotte Bin Zhang Joanne Mortimer Le Xuan Truong Nguyen Guido Marcucci |
| author_sort | HyunJun Kang |
| collection | DOAJ |
| description | Abstract Natural products have long been a viable source of therapeutic agents, providing unique structures and mechanisms that may be beneficial for cancer treatment. Herein we first report on the anticancer activity OST-01, a natural product from Baccharis Coridifolia, on breast cancer cells, including triple-negative breast cancer (TNBC). OST-01 significantly inhibited cell proliferation and oncogenic activities of TNBC cells in vitro. OST-01 also markedly inhibited TNBC tumor growth in vivo, with > 50% reduction in tumor size compared to vehicle control treatment in different in vivo models, i.e., cell line-derived (CDX), patient-derived (PDX), and mammary fat pad xenografts. Mechanistically, OST-01 induces ferroptosis by downregulating LRP8-regulated selenoproteins, i.e., GPX4. A shift from a basal-mesenchymal to a luminal-epithelial state of breast cancer stem cells (BCSCs) as supported by the downregulation of stemness (e.g., CD44) and mesenchymal (e.g., FN1 and vimentin) markers, along with the upregulation of differentiation markers (e.g., CD24) and luminal-epithelial markers (e.g., CK19), was also observed. |
| format | Article |
| id | doaj-art-019c7a3a0149434ebb0364aaf15b3494 |
| institution | Kabale University |
| issn | 1756-8722 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj-art-019c7a3a0149434ebb0364aaf15b34942025-02-09T12:51:23ZengBMCJournal of Hematology & Oncology1756-87222025-02-011811610.1186/s13045-025-01668-4Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cellsHyunJun Kang0Dinh Hoa Hoang1Melissa Valerio2Khyatiben Pathak3William Graff4Alexis LeVee5Jun Wu6Mark A. LaBarge7David Frankhouser8Russell C. Rockne9Patrick Pirrotte10Bin Zhang11Joanne Mortimer12Le Xuan Truong Nguyen13Guido Marcucci14Department of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical CenterDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical CenterDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical CenterEarly Detection and Prevention Division, Translational Genomics Research InstituteOstentus Therapeutics, IncDivision of Medical Oncology and Experimental Therapeutics, Beckman Research Institute and City of Hope National Medical CenterCity of Hope Comprehensive Cancer CenterDepartment of Population Sciences, Beckman Research Institute and City of Hope National Medical CenterDepartment of Computational and Quantitative Medicine, Division of Mathematical Oncology, Beckman Research Institute and City of Hope National Medical CenterDepartment of Computational and Quantitative Medicine, Division of Mathematical Oncology, Beckman Research Institute and City of Hope National Medical CenterEarly Detection and Prevention Division, Translational Genomics Research InstituteDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical CenterDivision of Medical Oncology and Experimental Therapeutics, Beckman Research Institute and City of Hope National Medical CenterDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical CenterDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute and City of Hope National Medical CenterAbstract Natural products have long been a viable source of therapeutic agents, providing unique structures and mechanisms that may be beneficial for cancer treatment. Herein we first report on the anticancer activity OST-01, a natural product from Baccharis Coridifolia, on breast cancer cells, including triple-negative breast cancer (TNBC). OST-01 significantly inhibited cell proliferation and oncogenic activities of TNBC cells in vitro. OST-01 also markedly inhibited TNBC tumor growth in vivo, with > 50% reduction in tumor size compared to vehicle control treatment in different in vivo models, i.e., cell line-derived (CDX), patient-derived (PDX), and mammary fat pad xenografts. Mechanistically, OST-01 induces ferroptosis by downregulating LRP8-regulated selenoproteins, i.e., GPX4. A shift from a basal-mesenchymal to a luminal-epithelial state of breast cancer stem cells (BCSCs) as supported by the downregulation of stemness (e.g., CD44) and mesenchymal (e.g., FN1 and vimentin) markers, along with the upregulation of differentiation markers (e.g., CD24) and luminal-epithelial markers (e.g., CK19), was also observed.https://doi.org/10.1186/s13045-025-01668-4TNBCBCSCNatural productOST-01Ferroptosis |
| spellingShingle | HyunJun Kang Dinh Hoa Hoang Melissa Valerio Khyatiben Pathak William Graff Alexis LeVee Jun Wu Mark A. LaBarge David Frankhouser Russell C. Rockne Patrick Pirrotte Bin Zhang Joanne Mortimer Le Xuan Truong Nguyen Guido Marcucci Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells Journal of Hematology & Oncology TNBC BCSC Natural product OST-01 Ferroptosis |
| title | Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells |
| title_full | Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells |
| title_fullStr | Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells |
| title_full_unstemmed | Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells |
| title_short | Pharmacological activity of OST-01, a natural product from baccharis coridifolia, on breast cancer cells |
| title_sort | pharmacological activity of ost 01 a natural product from baccharis coridifolia on breast cancer cells |
| topic | TNBC BCSC Natural product OST-01 Ferroptosis |
| url | https://doi.org/10.1186/s13045-025-01668-4 |
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