Genetic predisposition for ovarian cancer development
Ovarian cancer is a leading malignancy in the female reproductive system and is responsible for more deaths than any other type of cancer affecting this system. Ovarian cancers can be hereditary or sporadic. Anatomic, cellular, microenvironmental and molecular features of ovarian cancers show a high...
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| Format: | Article |
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2025-01-01
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| Series: | Arhiv za farmaciju |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2025/0004-19632501032J.pdf |
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| author | Joksić Ivana Prosenc-Zmrzljak Uršula Ninić Ana Ratković Tamara Munjas Jelena |
| author_facet | Joksić Ivana Prosenc-Zmrzljak Uršula Ninić Ana Ratković Tamara Munjas Jelena |
| author_sort | Joksić Ivana |
| collection | DOAJ |
| description | Ovarian cancer is a leading malignancy in the female reproductive system and is responsible for more deaths than any other type of cancer affecting this system. Ovarian cancers can be hereditary or sporadic. Anatomic, cellular, microenvironmental and molecular features of ovarian cancers show a high degree of heterogeneity. Numerous genes implicated in the pathogenesis and progression of ovarian cancers have been identified to date. The majority of these genes act as tumour suppressor genes, oncogenes, or are involved in mismatch repair and double-strand break repair mechanisms. The identification of mutations in cancer susceptibility genes could be a major step forward towards earlier diagnosis, personalized therapy approaches and outcome monitoring. In healthy women, detecting a specific mutated gene can provide a rationale for personalized surveillance, chemopreventive strategies, and prophylactic surgery. Next-generation sequencing offers comprehensive genome analysis, which enables profound understanding and identification of cancer susceptibility genes, and new molecular diagnostic markers and therapeutic targets. |
| format | Article |
| id | doaj-art-01954a9fa4a34fb0ac417e9ae2acb330 |
| institution | DOAJ |
| issn | 0004-1963 2217-8767 |
| language | srp |
| publishDate | 2025-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj-art-01954a9fa4a34fb0ac417e9ae2acb3302025-08-20T02:54:58ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672025-01-01751324310.5937/arhfarm75-551200004-19632501032JGenetic predisposition for ovarian cancer developmentJoksić Ivana0Prosenc-Zmrzljak Uršula1Ninić Ana2https://orcid.org/0000-0003-3838-1606Ratković Tamara3Munjas Jelena4https://orcid.org/0000-0002-4576-1722Obstetrics and Gynaecology Clinic "Narodni Front", Genetic Laboratory Department, Belgrade, SerbiaBIA Separations CRO, Labena Ltd., Slovenia, LjubljanaUniversity of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, SerbiaUniversity of Belgrade, Faculty of Pharmacy, Department of Medical Biochemistry, Belgrade, SerbiaOvarian cancer is a leading malignancy in the female reproductive system and is responsible for more deaths than any other type of cancer affecting this system. Ovarian cancers can be hereditary or sporadic. Anatomic, cellular, microenvironmental and molecular features of ovarian cancers show a high degree of heterogeneity. Numerous genes implicated in the pathogenesis and progression of ovarian cancers have been identified to date. The majority of these genes act as tumour suppressor genes, oncogenes, or are involved in mismatch repair and double-strand break repair mechanisms. The identification of mutations in cancer susceptibility genes could be a major step forward towards earlier diagnosis, personalized therapy approaches and outcome monitoring. In healthy women, detecting a specific mutated gene can provide a rationale for personalized surveillance, chemopreventive strategies, and prophylactic surgery. Next-generation sequencing offers comprehensive genome analysis, which enables profound understanding and identification of cancer susceptibility genes, and new molecular diagnostic markers and therapeutic targets.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2025/0004-19632501032J.pdfovarian cancergenetic predispositionbrcap53 |
| spellingShingle | Joksić Ivana Prosenc-Zmrzljak Uršula Ninić Ana Ratković Tamara Munjas Jelena Genetic predisposition for ovarian cancer development Arhiv za farmaciju ovarian cancer genetic predisposition brca p53 |
| title | Genetic predisposition for ovarian cancer development |
| title_full | Genetic predisposition for ovarian cancer development |
| title_fullStr | Genetic predisposition for ovarian cancer development |
| title_full_unstemmed | Genetic predisposition for ovarian cancer development |
| title_short | Genetic predisposition for ovarian cancer development |
| title_sort | genetic predisposition for ovarian cancer development |
| topic | ovarian cancer genetic predisposition brca p53 |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2025/0004-19632501032J.pdf |
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