Retinoic acid receptor-related orphan receptor α regulates bystander activation of memory CD8+ T cells

Retinoic acid receptor-related orphan receptor α regulates bystander activation of memory CD8+ T cells

BackgroundMemory CD8+ T cells sense inflammation and rapidly produce interferon-γ (IFN-γ) independent of cognate antigens. This innate-like property, called bystander activation, is involved in early host defense before the antigen-specific memory response. However, the molecular mechanisms underlyi...

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Bibliographic Details
Main Authors: Zimeng Cai, Mina Kozai, Hironobu Mita, Hiroto Takeuchi, Satoru Mizuno, Kazuhiro Matsuo, Kensuke Takada
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
T cells
immunological memory
bystander activation
inflammation
nuclear receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1647746/full
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