Modulating the Interactions of Peptide‐Polyphenol for Supramolecular Assembly Coatings with Controllable Kinetics and Multifunctionalities
Abstract Polyphenols and peptides represent two fundamental building blocks in the kingdom of supramolecular assembly (SA) coatings, which have recently attracted considerable interest. Regulating the assembly kinetics of SA coatings is critical to controlling the performance of SA coatings, but thi...
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202412194 |
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| author | Kaiyuan Huo Wenjie Liu Zeyu Shou Hongxiang Wang Hao Liu Yang Chen Xingjie Zan Qing Wang Na Li |
| author_facet | Kaiyuan Huo Wenjie Liu Zeyu Shou Hongxiang Wang Hao Liu Yang Chen Xingjie Zan Qing Wang Na Li |
| author_sort | Kaiyuan Huo |
| collection | DOAJ |
| description | Abstract Polyphenols and peptides represent two fundamental building blocks in the kingdom of supramolecular assembly (SA) coatings, which have recently attracted considerable interest. Regulating the assembly kinetics of SA coatings is critical to controlling the performance of SA coatings, but this area is still in its infancy, especially in the SA coating of peptide‐polyphenol. Herein, a library of oligopeptides with rich diversity, numerous polyphenols, and modulators are explored to reveal their roles in the formation and regulation of SA coating. Citric acid (CA) is an effective regulator of interaction between the polyphenols and peptides to produce peptide‐polyphenol coatings, TCP. The electrostatic interaction between tannic acid (TA) and cationic peptide drives the formation of TCP, while the multiple hydrogen bonds between CA and TA and peptide dominate the assembly kinetics. With optimized assembly pH and the mass ratio of TA, CA, and peptide, the thickness of TCP coating deposits onto diverse substrates (glass, silica, titanium, polystyrene) is ≈400 nm with controllable kinetics. The multifunctional TCP coatings are endowed via peptide‐coupled functional units, including enhanced cellular adhesion, elevated osteogenic capacity, anti‐protein adsorption, and antimicrobial. This work contributes to the understanding of the assembly kinetics and functionalization of peptide‐polyphenol coatings. |
| format | Article |
| id | doaj-art-0189fa7ceaef4f37879a86163aca8b8c |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-0189fa7ceaef4f37879a86163aca8b8c2025-01-20T13:04:18ZengWileyAdvanced Science2198-38442025-01-01123n/an/a10.1002/advs.202412194Modulating the Interactions of Peptide‐Polyphenol for Supramolecular Assembly Coatings with Controllable Kinetics and MultifunctionalitiesKaiyuan Huo0Wenjie Liu1Zeyu Shou2Hongxiang Wang3Hao Liu4Yang Chen5Xingjie Zan6Qing Wang7Na Li8School of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University Wenzhou Zhejiang 325027 ChinaWenzhou Institute University of Chinese Academy of Sciences Wenzhou Key Laboratory of Perioperative Medicine Wenzhou Zhejiang 325001 ChinaWenzhou Institute University of Chinese Academy of Sciences Wenzhou Key Laboratory of Perioperative Medicine Wenzhou Zhejiang 325001 ChinaSchool of Pharmacy Zhejiang Chinese Medical University Hangzhou Zhejiang 310053 ChinaSchool of Materials Science and Engineering Zhengzhou University Zhengzhou 450001 ChinaSchool of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University Wenzhou Zhejiang 325027 ChinaSchool of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University Wenzhou Zhejiang 325027 ChinaYongkang First People's Hospital of Wenzhou Medical University Yongkang Zhejiang 321300 ChinaSchool of Ophthalmology and Optometry School of Biomedical Engineering Wenzhou Medical University Wenzhou Zhejiang 325027 ChinaAbstract Polyphenols and peptides represent two fundamental building blocks in the kingdom of supramolecular assembly (SA) coatings, which have recently attracted considerable interest. Regulating the assembly kinetics of SA coatings is critical to controlling the performance of SA coatings, but this area is still in its infancy, especially in the SA coating of peptide‐polyphenol. Herein, a library of oligopeptides with rich diversity, numerous polyphenols, and modulators are explored to reveal their roles in the formation and regulation of SA coating. Citric acid (CA) is an effective regulator of interaction between the polyphenols and peptides to produce peptide‐polyphenol coatings, TCP. The electrostatic interaction between tannic acid (TA) and cationic peptide drives the formation of TCP, while the multiple hydrogen bonds between CA and TA and peptide dominate the assembly kinetics. With optimized assembly pH and the mass ratio of TA, CA, and peptide, the thickness of TCP coating deposits onto diverse substrates (glass, silica, titanium, polystyrene) is ≈400 nm with controllable kinetics. The multifunctional TCP coatings are endowed via peptide‐coupled functional units, including enhanced cellular adhesion, elevated osteogenic capacity, anti‐protein adsorption, and antimicrobial. This work contributes to the understanding of the assembly kinetics and functionalization of peptide‐polyphenol coatings.https://doi.org/10.1002/advs.202412194coatingsmultifunctionalitiespeptidespolyphenolssupramolecular assembly |
| spellingShingle | Kaiyuan Huo Wenjie Liu Zeyu Shou Hongxiang Wang Hao Liu Yang Chen Xingjie Zan Qing Wang Na Li Modulating the Interactions of Peptide‐Polyphenol for Supramolecular Assembly Coatings with Controllable Kinetics and Multifunctionalities Advanced Science coatings multifunctionalities peptides polyphenols supramolecular assembly |
| title | Modulating the Interactions of Peptide‐Polyphenol for Supramolecular Assembly Coatings with Controllable Kinetics and Multifunctionalities |
| title_full | Modulating the Interactions of Peptide‐Polyphenol for Supramolecular Assembly Coatings with Controllable Kinetics and Multifunctionalities |
| title_fullStr | Modulating the Interactions of Peptide‐Polyphenol for Supramolecular Assembly Coatings with Controllable Kinetics and Multifunctionalities |
| title_full_unstemmed | Modulating the Interactions of Peptide‐Polyphenol for Supramolecular Assembly Coatings with Controllable Kinetics and Multifunctionalities |
| title_short | Modulating the Interactions of Peptide‐Polyphenol for Supramolecular Assembly Coatings with Controllable Kinetics and Multifunctionalities |
| title_sort | modulating the interactions of peptide polyphenol for supramolecular assembly coatings with controllable kinetics and multifunctionalities |
| topic | coatings multifunctionalities peptides polyphenols supramolecular assembly |
| url | https://doi.org/10.1002/advs.202412194 |
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