Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model

Repeated positron emission tomography tracing neutrophil elastase in a porcine intensive-care sepsis model

Abstract Background Neutrophil granulocytes are important parts of the defence against bacterial infections. Their action is a two-edged sword, the mediators killing the intruding bacteria are at the same time causing tissue damage. Neutrophil activation is part of the dysregulated immune response t...

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Main Authors: Frida Wilske, Olof Eriksson, Rose-Marie Amini, Sergio Estrada, Helena Janols, Amina Khalil, Anders Larsson, Miklós Lipcsey, Sara Mangsbo, Jonathan Sigfridsson, Jan Sjölin, Paul Skorup, Anders Wall, Viola Wilson, Markus Castegren, Gunnar Antoni
Format: Article
Language:English
Published: SpringerOpen 2025-02-01
Series:Intensive Care Medicine Experimental
Subjects:
Porcine
Sepsis
PET
Neutrophil elastase
E coli
[11C]NES
Online Access:https://doi.org/10.1186/s40635-025-00721-3
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