Current Requirements for and Approaches to Dosing in Animal Studies
Today, within the context of harmonisation of requirements in the international pharmaceutical market, there is a trend towards development of common standards, including in the field of preclinical studies. The reliability and reproducibility of experimental data obtained in various laboratories us...
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| Format: | Article |
| Language: | Russian |
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Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)
2018-12-01
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| Series: | Регуляторные исследования и экспертиза лекарственных средств |
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| Online Access: | https://www.vedomostincesmp.ru/jour/article/view/163 |
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| author | A. V. Rybakova M. N. Makarova A. E. Kukharenko A. S. Vichare F. R. Rueffer |
| author_facet | A. V. Rybakova M. N. Makarova A. E. Kukharenko A. S. Vichare F. R. Rueffer |
| author_sort | A. V. Rybakova |
| collection | DOAJ |
| description | Today, within the context of harmonisation of requirements in the international pharmaceutical market, there is a trend towards development of common standards, including in the field of preclinical studies. The reliability and reproducibility of experimental data obtained in various laboratories using animals cannot be guaranteed unless the 3Rs principles are observed (the principles of humane experimental technique) to ensure the welfare of animals. The present paper analyses Russian and foreign recommendations on different administration routes and administered volumes as applied to mice, rats, guinea pigs, and rabbits – the most frequently used laboratory animals. The paper systematises literature data on oral/intragastric, subcutaneous, intramuscular, intravenous and intraperitoneal routes of administration. It assesses potential complications of each route of administration, and negative effects on both health and well-being of laboratory animals, as well as on the results of experiments. The paper also touches upon some anatomical and physiological characteristics of laboratory animals, potential opportunities for feed and water deprivation, ways of reducing pain in animals. The results of comparison of administered volumes helped to determine optimal recommended and maximum administered volumes. |
| format | Article |
| id | doaj-art-018656d4580c42aaafea4e388fd55109 |
| institution | Kabale University |
| issn | 3034-3062 3034-3453 |
| language | Russian |
| publishDate | 2018-12-01 |
| publisher | Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’) |
| record_format | Article |
| series | Регуляторные исследования и экспертиза лекарственных средств |
| spelling | doaj-art-018656d4580c42aaafea4e388fd551092025-08-20T03:40:14ZrusFederal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’)Регуляторные исследования и экспертиза лекарственных средств3034-30623034-34532018-12-018420721710.30895/1991-2919-2018-8-4-207-217175Current Requirements for and Approaches to Dosing in Animal StudiesA. V. Rybakova0M. N. Makarova1A. E. Kukharenko2A. S. Vichare3F. R. Rueffer4Scientific and Production Association "HOME PHARMACY"Scientific and Production Association "HOME PHARMACY"Abbott Laboratories LLCAbbott Healthcare Pvt. Ltd.Abbott Laboratories GmbHToday, within the context of harmonisation of requirements in the international pharmaceutical market, there is a trend towards development of common standards, including in the field of preclinical studies. The reliability and reproducibility of experimental data obtained in various laboratories using animals cannot be guaranteed unless the 3Rs principles are observed (the principles of humane experimental technique) to ensure the welfare of animals. The present paper analyses Russian and foreign recommendations on different administration routes and administered volumes as applied to mice, rats, guinea pigs, and rabbits – the most frequently used laboratory animals. The paper systematises literature data on oral/intragastric, subcutaneous, intramuscular, intravenous and intraperitoneal routes of administration. It assesses potential complications of each route of administration, and negative effects on both health and well-being of laboratory animals, as well as on the results of experiments. The paper also touches upon some anatomical and physiological characteristics of laboratory animals, potential opportunities for feed and water deprivation, ways of reducing pain in animals. The results of comparison of administered volumes helped to determine optimal recommended and maximum administered volumes.https://www.vedomostincesmp.ru/jour/article/view/163administered volumedosinglaboratory animalswell-being of laboratory animalshumane treatment of laboratory animals |
| spellingShingle | A. V. Rybakova M. N. Makarova A. E. Kukharenko A. S. Vichare F. R. Rueffer Current Requirements for and Approaches to Dosing in Animal Studies Регуляторные исследования и экспертиза лекарственных средств administered volume dosing laboratory animals well-being of laboratory animals humane treatment of laboratory animals |
| title | Current Requirements for and Approaches to Dosing in Animal Studies |
| title_full | Current Requirements for and Approaches to Dosing in Animal Studies |
| title_fullStr | Current Requirements for and Approaches to Dosing in Animal Studies |
| title_full_unstemmed | Current Requirements for and Approaches to Dosing in Animal Studies |
| title_short | Current Requirements for and Approaches to Dosing in Animal Studies |
| title_sort | current requirements for and approaches to dosing in animal studies |
| topic | administered volume dosing laboratory animals well-being of laboratory animals humane treatment of laboratory animals |
| url | https://www.vedomostincesmp.ru/jour/article/view/163 |
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