Induction and Stabilization of Antibacterial Activity in a Bacillus subtilis 534 Probiotic Strain
Medicinal probiotic Sporobacterin is based on the Bacillus subtilis 534 strain, which has been shown to have antimicrobial activity against many bacteria, both the collection strains and the antibiotic-resistant forms of clinical isolates of pathogenic bacteria and fungi. Considering this strain as...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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LLC "Publishing House OKI"
2022-12-01
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| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/962 |
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| author | O. V. Efremenkova I. A. Malanicheva B. F. Vasileva T. A. Efimenko A. A. Glukhova O. V. Kisil M. V. Demiankova H. S. Semizaev N. I. Gabrielyan |
| author_facet | O. V. Efremenkova I. A. Malanicheva B. F. Vasileva T. A. Efimenko A. A. Glukhova O. V. Kisil M. V. Demiankova H. S. Semizaev N. I. Gabrielyan |
| author_sort | O. V. Efremenkova |
| collection | DOAJ |
| description | Medicinal probiotic Sporobacterin is based on the Bacillus subtilis 534 strain, which has been shown to have antimicrobial activity against many bacteria, both the collection strains and the antibiotic-resistant forms of clinical isolates of pathogenic bacteria and fungi. Considering this strain as an antibiotic producer, a step-by-step mutagenic treatment was carried out in order to obtain a variant that consistently exhibits a certain high-level antibiotic activity. A mutant variant was obtained during the three stages of mutagenic treatment and selection; it effectively suppresses the growth of pathogenic staphylococci, including methicillin-resistant staphylococcus (MRSA). |
| format | Article |
| id | doaj-art-018510ff4b4f4b5bb9b0012a6aebcdec |
| institution | Kabale University |
| issn | 0235-2990 |
| language | Russian |
| publishDate | 2022-12-01 |
| publisher | LLC "Publishing House OKI" |
| record_format | Article |
| series | Антибиотики и Химиотерапия |
| spelling | doaj-art-018510ff4b4f4b5bb9b0012a6aebcdec2025-08-20T03:37:09ZrusLLC "Publishing House OKI"Антибиотики и Химиотерапия0235-29902022-12-01679-1041010.37489/0235-2990-2022-67-9-10-4-10865Induction and Stabilization of Antibacterial Activity in a Bacillus subtilis 534 Probiotic StrainO. V. Efremenkova0I. A. Malanicheva1B. F. Vasileva2T. A. Efimenko3A. A. Glukhova4O. V. Kisil5M. V. Demiankova6H. S. Semizaev7N. I. Gabrielyan8Gause Institute of New AntibioticsGause Institute of New AntibioticsGause Institute of New AntibioticsGause Institute of New AntibioticsGause Institute of New AntibioticsGause Institute of New AntibioticsGause Institute of New Antibiotics; Federal Research Centre of Transplantology and Artificial Organs named after academician V. I. Shumakov of the Ministry of Health of the Russian FederationGause Institute of New AntibioticsFederal Research Centre of Transplantology and Artificial Organs named after academician V. I. Shumakov of the Ministry of Health of the Russian FederationMedicinal probiotic Sporobacterin is based on the Bacillus subtilis 534 strain, which has been shown to have antimicrobial activity against many bacteria, both the collection strains and the antibiotic-resistant forms of clinical isolates of pathogenic bacteria and fungi. Considering this strain as an antibiotic producer, a step-by-step mutagenic treatment was carried out in order to obtain a variant that consistently exhibits a certain high-level antibiotic activity. A mutant variant was obtained during the three stages of mutagenic treatment and selection; it effectively suppresses the growth of pathogenic staphylococci, including methicillin-resistant staphylococcus (MRSA).https://www.antibiotics-chemotherapy.ru/jour/article/view/962antibioticsantibiotic resistanceprobioticssporobacterinbacillus subtilisstaphylococcus aureus |
| spellingShingle | O. V. Efremenkova I. A. Malanicheva B. F. Vasileva T. A. Efimenko A. A. Glukhova O. V. Kisil M. V. Demiankova H. S. Semizaev N. I. Gabrielyan Induction and Stabilization of Antibacterial Activity in a Bacillus subtilis 534 Probiotic Strain Антибиотики и Химиотерапия antibiotics antibiotic resistance probiotics sporobacterin bacillus subtilis staphylococcus aureus |
| title | Induction and Stabilization of Antibacterial Activity in a Bacillus subtilis 534 Probiotic Strain |
| title_full | Induction and Stabilization of Antibacterial Activity in a Bacillus subtilis 534 Probiotic Strain |
| title_fullStr | Induction and Stabilization of Antibacterial Activity in a Bacillus subtilis 534 Probiotic Strain |
| title_full_unstemmed | Induction and Stabilization of Antibacterial Activity in a Bacillus subtilis 534 Probiotic Strain |
| title_short | Induction and Stabilization of Antibacterial Activity in a Bacillus subtilis 534 Probiotic Strain |
| title_sort | induction and stabilization of antibacterial activity in a bacillus subtilis 534 probiotic strain |
| topic | antibiotics antibiotic resistance probiotics sporobacterin bacillus subtilis staphylococcus aureus |
| url | https://www.antibiotics-chemotherapy.ru/jour/article/view/962 |
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