Optic nerve sonographic parameters in idiopathic intracranial hypertension, case-control study
Abstract The most common diagnostic error of IIH is inaccurate funduscopic examination. Moreover, IIH could be diagnosed without papilledema. Trans orbital sonography could be used as a non-invasive and cheap tool for discovering increased ICP (intracranial Pressure). Aim of our study was discoverin...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-024-85033-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594666376134656 |
|---|---|
| author | Islam El Malky Wael Elshazly Aita Alaa Elkordy Marwa Nasreldeen Mahmoud Abdelhafiz Amr M. Tael Hazem Mo. Abdelkhalek |
| author_facet | Islam El Malky Wael Elshazly Aita Alaa Elkordy Marwa Nasreldeen Mahmoud Abdelhafiz Amr M. Tael Hazem Mo. Abdelkhalek |
| author_sort | Islam El Malky |
| collection | DOAJ |
| description | Abstract The most common diagnostic error of IIH is inaccurate funduscopic examination. Moreover, IIH could be diagnosed without papilledema. Trans orbital sonography could be used as a non-invasive and cheap tool for discovering increased ICP (intracranial Pressure). Aim of our study was discovering the changes in ultra-sonographic indices and which one could predict the increased ICP. Sixty-eight patients were diagnosed as definite IIH and 68 healthy volunteers are included in the study who had the same sex and age. ONSD, peak systolic velocity (PSV), end diastolic velocity (EDV), and resistance index (RI) were estimated by transorbital color Doppler. Multivariate linear regression was used to discover the predictors of increased ICP. ROC curve was plotted for the predictor. A statistically significant difference was found between IIH patients and controls regarding ONSD, EDV and RI. Multivariate linear regression revealed that ONSD is the only predictor of increased CSP pressure. Its cut-off value indicating high ICP was 5.7 mm on Rt and Lt eye (AUC: 0.916; 95% confidence interval 0.867–0.965; p < 0.001; 90% sensitivity, 80% specificity at Rt eye. AUC: 0.902; 95% confidence interval 0.845–0.958; p < 0.001; 91% sensitivity, 80% specificity at Lt eye). |
| format | Article |
| id | doaj-art-018501e01c044b47bc251312c96c025a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-018501e01c044b47bc251312c96c025a2025-01-19T12:23:16ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-024-85033-4Optic nerve sonographic parameters in idiopathic intracranial hypertension, case-control studyIslam El Malky0Wael Elshazly Aita1Alaa Elkordy2Marwa Nasreldeen3Mahmoud Abdelhafiz4Amr M. Tael5Hazem Mo. Abdelkhalek6Department of Neurology, Director of Interventional Neurovascular Unit, South Valley UniversityMD Ophthalmology, Department of Ophthalmology, South Valley UniversityMD Neurology, Department of Neurology, Tanta UniversityMD Anesthesiology, Department of Anesthesiology, South Valley UniversityMD Neurology, Department of Neurology, South Valley UniversityMD Neurosurgery, Department of Neurosurgery, South Valley UniversityAssistant Professor of Neurology, Department of Neurology, Tanta UniversityAbstract The most common diagnostic error of IIH is inaccurate funduscopic examination. Moreover, IIH could be diagnosed without papilledema. Trans orbital sonography could be used as a non-invasive and cheap tool for discovering increased ICP (intracranial Pressure). Aim of our study was discovering the changes in ultra-sonographic indices and which one could predict the increased ICP. Sixty-eight patients were diagnosed as definite IIH and 68 healthy volunteers are included in the study who had the same sex and age. ONSD, peak systolic velocity (PSV), end diastolic velocity (EDV), and resistance index (RI) were estimated by transorbital color Doppler. Multivariate linear regression was used to discover the predictors of increased ICP. ROC curve was plotted for the predictor. A statistically significant difference was found between IIH patients and controls regarding ONSD, EDV and RI. Multivariate linear regression revealed that ONSD is the only predictor of increased CSP pressure. Its cut-off value indicating high ICP was 5.7 mm on Rt and Lt eye (AUC: 0.916; 95% confidence interval 0.867–0.965; p < 0.001; 90% sensitivity, 80% specificity at Rt eye. AUC: 0.902; 95% confidence interval 0.845–0.958; p < 0.001; 91% sensitivity, 80% specificity at Lt eye).https://doi.org/10.1038/s41598-024-85033-4IIHICPHeadacheONSDTransorbital ultrasonography |
| spellingShingle | Islam El Malky Wael Elshazly Aita Alaa Elkordy Marwa Nasreldeen Mahmoud Abdelhafiz Amr M. Tael Hazem Mo. Abdelkhalek Optic nerve sonographic parameters in idiopathic intracranial hypertension, case-control study Scientific Reports IIH ICP Headache ONSD Transorbital ultrasonography |
| title | Optic nerve sonographic parameters in idiopathic intracranial hypertension, case-control study |
| title_full | Optic nerve sonographic parameters in idiopathic intracranial hypertension, case-control study |
| title_fullStr | Optic nerve sonographic parameters in idiopathic intracranial hypertension, case-control study |
| title_full_unstemmed | Optic nerve sonographic parameters in idiopathic intracranial hypertension, case-control study |
| title_short | Optic nerve sonographic parameters in idiopathic intracranial hypertension, case-control study |
| title_sort | optic nerve sonographic parameters in idiopathic intracranial hypertension case control study |
| topic | IIH ICP Headache ONSD Transorbital ultrasonography |
| url | https://doi.org/10.1038/s41598-024-85033-4 |
| work_keys_str_mv | AT islamelmalky opticnervesonographicparametersinidiopathicintracranialhypertensioncasecontrolstudy AT waelelshazlyaita opticnervesonographicparametersinidiopathicintracranialhypertensioncasecontrolstudy AT alaaelkordy opticnervesonographicparametersinidiopathicintracranialhypertensioncasecontrolstudy AT marwanasreldeen opticnervesonographicparametersinidiopathicintracranialhypertensioncasecontrolstudy AT mahmoudabdelhafiz opticnervesonographicparametersinidiopathicintracranialhypertensioncasecontrolstudy AT amrmtael opticnervesonographicparametersinidiopathicintracranialhypertensioncasecontrolstudy AT hazemmoabdelkhalek opticnervesonographicparametersinidiopathicintracranialhypertensioncasecontrolstudy |