Carbon dioxide induced panic attacks and short term clonazepam treatment: preliminary study
AIMS: 1. To verify the sensibility of panic patients to a mixture of 35% CO2 and 65% O2. 2. To determine if a ten days treatment with clonazepam attenuates the panic attacks induced by the inhalation of 35% carbon dioxide in panic disorder. METHOD: We randomly selected six panic disorder subjects, u...
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| Language: | English |
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Thieme Revinter Publicações
1999-06-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000300003&tlng=en |
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| author | ANTONIO EGIDIO NARDI ALEXANDRE M. VALENÇA WALTER ZIN ISABELLA NASCIMENTO |
| author_facet | ANTONIO EGIDIO NARDI ALEXANDRE M. VALENÇA WALTER ZIN ISABELLA NASCIMENTO |
| author_sort | ANTONIO EGIDIO NARDI |
| collection | DOAJ |
| description | AIMS: 1. To verify the sensibility of panic patients to a mixture of 35% CO2 and 65% O2. 2. To determine if a ten days treatment with clonazepam attenuates the panic attacks induced by the inhalation of 35% carbon dioxide in panic disorder. METHOD: We randomly selected six panic disorder subjects, using the Structured Clinical Interview for DSM-IV. All subjects went double-blindly through an inhalation of 35% CO2 and compressed gas (atmospheric air) on two occasions. First, at baseline, when they were drug free. Second, after a 10 days clonazepam treatment. RESULTS: Neither at baseline nor after treatment any patient had a panic attack during compressed gas inhalation. At the first test five patients (83.3%) had a severe panic attack with high levels of subjective anxiety during carbon dioxide inhalation. After 9.6 (± 3.4) days of clonazepam treatment, only two (33.3%) patients experienced a mild panic attack. CONCLUSION: This pilot study suggests the efficacy of the short term clonazepam therapy in attenuating panic attacks and supports the usefulness of the 35% carbon dioxide challenge test as an analogue method for study the efficacy of anti-panic drugs. Further placebo-controlled studies to pharmacological treatment are warranted. |
| format | Article |
| id | doaj-art-0183523f7e93474a9815ef575f7b29e1 |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 1999-06-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-0183523f7e93474a9815ef575f7b29e12025-08-20T02:03:24ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42271999-06-01572B361365Carbon dioxide induced panic attacks and short term clonazepam treatment: preliminary studyANTONIO EGIDIO NARDI0ALEXANDRE M. VALENÇA1WALTER ZIN2ISABELLA NASCIMENTO3Federal University of Rio de JaneiroFederal University of Rio de JaneiroFederal University of Rio de JaneiroFederal University of Rio de JaneiroAIMS: 1. To verify the sensibility of panic patients to a mixture of 35% CO2 and 65% O2. 2. To determine if a ten days treatment with clonazepam attenuates the panic attacks induced by the inhalation of 35% carbon dioxide in panic disorder. METHOD: We randomly selected six panic disorder subjects, using the Structured Clinical Interview for DSM-IV. All subjects went double-blindly through an inhalation of 35% CO2 and compressed gas (atmospheric air) on two occasions. First, at baseline, when they were drug free. Second, after a 10 days clonazepam treatment. RESULTS: Neither at baseline nor after treatment any patient had a panic attack during compressed gas inhalation. At the first test five patients (83.3%) had a severe panic attack with high levels of subjective anxiety during carbon dioxide inhalation. After 9.6 (± 3.4) days of clonazepam treatment, only two (33.3%) patients experienced a mild panic attack. CONCLUSION: This pilot study suggests the efficacy of the short term clonazepam therapy in attenuating panic attacks and supports the usefulness of the 35% carbon dioxide challenge test as an analogue method for study the efficacy of anti-panic drugs. Further placebo-controlled studies to pharmacological treatment are warranted.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000300003&tlng=enpanic attackspanic disorderclonazepamcarbon dioxide |
| spellingShingle | ANTONIO EGIDIO NARDI ALEXANDRE M. VALENÇA WALTER ZIN ISABELLA NASCIMENTO Carbon dioxide induced panic attacks and short term clonazepam treatment: preliminary study Arquivos de Neuro-Psiquiatria panic attacks panic disorder clonazepam carbon dioxide |
| title | Carbon dioxide induced panic attacks and short term clonazepam treatment: preliminary study |
| title_full | Carbon dioxide induced panic attacks and short term clonazepam treatment: preliminary study |
| title_fullStr | Carbon dioxide induced panic attacks and short term clonazepam treatment: preliminary study |
| title_full_unstemmed | Carbon dioxide induced panic attacks and short term clonazepam treatment: preliminary study |
| title_short | Carbon dioxide induced panic attacks and short term clonazepam treatment: preliminary study |
| title_sort | carbon dioxide induced panic attacks and short term clonazepam treatment preliminary study |
| topic | panic attacks panic disorder clonazepam carbon dioxide |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1999000300003&tlng=en |
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