Comparative Analysis of Changes of Myocardial Angiogenesis and Energy Metabolism in Postinfarction and Diabetic Damage of Rat Heart
Comparative study of changes in myocardial activity of lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), and capillary density distribution in the experimental models of diabetic and postinfarction damage of rat heart was performed. Data showed that decrease in LDH and SDH activities was o...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2014/827896 |
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| author | Sergey A. Afanasiev Margarita V. Egorova Dina S. Kondratyeva Roman E. Batalov Sergey V. Popov |
| author_facet | Sergey A. Afanasiev Margarita V. Egorova Dina S. Kondratyeva Roman E. Batalov Sergey V. Popov |
| author_sort | Sergey A. Afanasiev |
| collection | DOAJ |
| description | Comparative study of changes in myocardial activity of lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), and capillary density distribution in the experimental models of diabetic and postinfarction damage of rat heart was performed. Data showed that decrease in LDH and SDH activities was observed in both pathologies which can suggest abnormal processes of glycolysis and oxidative phosphorylation in cardiac mitochondria. Activity of LDH and SDH in combined pathologies was comparative with the corresponding values of these parameters in control group. The authors hypothesize that these differences can be caused by specifics of myocardial vascularization. The results of the study showed that an increase in capillary density was found in all groups of rats with pathologies compared with control group. However, no significant differences in the intensity of angiogenesis processes were found between groups with pathologies. |
| format | Article |
| id | doaj-art-0182e15d40b34e59a456972f69bc1e0a |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-0182e15d40b34e59a456972f69bc1e0a2025-08-20T02:03:24ZengWileyJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/827896827896Comparative Analysis of Changes of Myocardial Angiogenesis and Energy Metabolism in Postinfarction and Diabetic Damage of Rat HeartSergey A. Afanasiev0Margarita V. Egorova1Dina S. Kondratyeva2Roman E. Batalov3Sergey V. Popov4FSBI “RI Cardiology” SB RAMS, 111a Kievskaya Street, Tomsk 634012, RussiaFSBI “RI Cardiology” SB RAMS, 111a Kievskaya Street, Tomsk 634012, RussiaFSBI “RI Cardiology” SB RAMS, 111a Kievskaya Street, Tomsk 634012, RussiaFSBI “RI Cardiology” SB RAMS, 111a Kievskaya Street, Tomsk 634012, RussiaFSBI “RI Cardiology” SB RAMS, 111a Kievskaya Street, Tomsk 634012, RussiaComparative study of changes in myocardial activity of lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), and capillary density distribution in the experimental models of diabetic and postinfarction damage of rat heart was performed. Data showed that decrease in LDH and SDH activities was observed in both pathologies which can suggest abnormal processes of glycolysis and oxidative phosphorylation in cardiac mitochondria. Activity of LDH and SDH in combined pathologies was comparative with the corresponding values of these parameters in control group. The authors hypothesize that these differences can be caused by specifics of myocardial vascularization. The results of the study showed that an increase in capillary density was found in all groups of rats with pathologies compared with control group. However, no significant differences in the intensity of angiogenesis processes were found between groups with pathologies.http://dx.doi.org/10.1155/2014/827896 |
| spellingShingle | Sergey A. Afanasiev Margarita V. Egorova Dina S. Kondratyeva Roman E. Batalov Sergey V. Popov Comparative Analysis of Changes of Myocardial Angiogenesis and Energy Metabolism in Postinfarction and Diabetic Damage of Rat Heart Journal of Diabetes Research |
| title | Comparative Analysis of Changes of Myocardial Angiogenesis and Energy Metabolism in Postinfarction and Diabetic Damage of Rat Heart |
| title_full | Comparative Analysis of Changes of Myocardial Angiogenesis and Energy Metabolism in Postinfarction and Diabetic Damage of Rat Heart |
| title_fullStr | Comparative Analysis of Changes of Myocardial Angiogenesis and Energy Metabolism in Postinfarction and Diabetic Damage of Rat Heart |
| title_full_unstemmed | Comparative Analysis of Changes of Myocardial Angiogenesis and Energy Metabolism in Postinfarction and Diabetic Damage of Rat Heart |
| title_short | Comparative Analysis of Changes of Myocardial Angiogenesis and Energy Metabolism in Postinfarction and Diabetic Damage of Rat Heart |
| title_sort | comparative analysis of changes of myocardial angiogenesis and energy metabolism in postinfarction and diabetic damage of rat heart |
| url | http://dx.doi.org/10.1155/2014/827896 |
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