Clinical research of photodynamic therapy with 5-ALA for cervical intraepithelial neoplasms: from preliminary studies to current developments
Non-surgical therapies are essential for reducing the progression rate of human papillomavirus-associated cervical intraepithelial neoplasia (CIN) from low-grade (CIN 1) to high-grade CIN (CIN 2/3) and subsequently to cervical cancer with minimal adverse reactions and complications in women, such as...
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| Format: | Article |
| Language: | Russian |
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Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2025-07-01
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| Series: | Biomedical Photonics |
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| Online Access: | https://www.pdt-journal.com/jour/article/view/720 |
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| author | N. A. Shanazarov A. D. Aitkaliyev T. G. Grishacheva S. D. Kissikova S. V. Zinchenko B. S. Kassiyeva S. B. Smailova Zh. Zh. Salmagambetova K. Seitbekova |
| author_facet | N. A. Shanazarov A. D. Aitkaliyev T. G. Grishacheva S. D. Kissikova S. V. Zinchenko B. S. Kassiyeva S. B. Smailova Zh. Zh. Salmagambetova K. Seitbekova |
| author_sort | N. A. Shanazarov |
| collection | DOAJ |
| description | Non-surgical therapies are essential for reducing the progression rate of human papillomavirus-associated cervical intraepithelial neoplasia (CIN) from low-grade (CIN 1) to high-grade CIN (CIN 2/3) and subsequently to cervical cancer with minimal adverse reactions and complications in women, such as haemorrhaging, cervical stenosis, spontaneous abortion, and preterm birth.Photodynamic therapy (PDT) has garnered considerable attention as a non-invasive approach to CIN treatment in recent years. PDT works by applying photoactive compounds, known as photosensitizers, that accumulate in target cells. Subsequent exposure of these cells to light of a specific wavelength (photoactivation) occurs. This paper aims to review the clinical development of clinical research on the effectiveness of PDT with a 5-Aminolevulinic acid (5-ALA) photosensitiser for treating CIN 1-3 from the early preliminary studies to recent reports.Early PDT studies using lower concentrations of 5-ALA showed poor effectiveness, but recent research with a 20% concentration of 5-ALA demonstrated better outcomes. Larger studies, preferably conducted across multiple centres, are needed to establish the optimal number of PDT sessions required to eliminate HPV. |
| format | Article |
| id | doaj-art-017c2742fefe4c10b35a6f2c7e9a6721 |
| institution | DOAJ |
| issn | 2413-9432 |
| language | Russian |
| publishDate | 2025-07-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj-art-017c2742fefe4c10b35a6f2c7e9a67212025-08-20T03:21:05ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322025-07-01142313910.24931/2413-9432-2025-14-2-31-39319Clinical research of photodynamic therapy with 5-ALA for cervical intraepithelial neoplasms: from preliminary studies to current developmentsN. A. Shanazarov0A. D. Aitkaliyev1T. G. Grishacheva2S. D. Kissikova3S. V. Zinchenko4B. S. Kassiyeva5S. B. Smailova6Zh. Zh. Salmagambetova7K. Seitbekova8Medical Center Hospital of the President’s Affairs Administration of the Republic of KazakhstanMedical Center Hospital of the President’s Affairs Administration of the Republic of KazakhstanPavlov First Saint-Petersburg State Medical UniversityMedical Center Hospital of the President’s Affairs Administration of the Republic of KazakhstanKazan (Volga Region) Federal UniversityMedical Center Hospital of the President’s Affairs Administration of the Republic of KazakhstanMedical Center Hospital of the President’s Affairs Administration of the Republic of KazakhstanMedical Center Hospital of the President’s Affairs Administration of the Republic of KazakhstanMedical Center Hospital of the President’s Affairs Administration of the Republic of KazakhstanNon-surgical therapies are essential for reducing the progression rate of human papillomavirus-associated cervical intraepithelial neoplasia (CIN) from low-grade (CIN 1) to high-grade CIN (CIN 2/3) and subsequently to cervical cancer with minimal adverse reactions and complications in women, such as haemorrhaging, cervical stenosis, spontaneous abortion, and preterm birth.Photodynamic therapy (PDT) has garnered considerable attention as a non-invasive approach to CIN treatment in recent years. PDT works by applying photoactive compounds, known as photosensitizers, that accumulate in target cells. Subsequent exposure of these cells to light of a specific wavelength (photoactivation) occurs. This paper aims to review the clinical development of clinical research on the effectiveness of PDT with a 5-Aminolevulinic acid (5-ALA) photosensitiser for treating CIN 1-3 from the early preliminary studies to recent reports.Early PDT studies using lower concentrations of 5-ALA showed poor effectiveness, but recent research with a 20% concentration of 5-ALA demonstrated better outcomes. Larger studies, preferably conducted across multiple centres, are needed to establish the optimal number of PDT sessions required to eliminate HPV.https://www.pdt-journal.com/jour/article/view/720cervical intraepithelial neoplasiaphotodynamic therapyhuman papillomavirus5-aminolevulinic acidsquamous intraepithelial lesions |
| spellingShingle | N. A. Shanazarov A. D. Aitkaliyev T. G. Grishacheva S. D. Kissikova S. V. Zinchenko B. S. Kassiyeva S. B. Smailova Zh. Zh. Salmagambetova K. Seitbekova Clinical research of photodynamic therapy with 5-ALA for cervical intraepithelial neoplasms: from preliminary studies to current developments Biomedical Photonics cervical intraepithelial neoplasia photodynamic therapy human papillomavirus 5-aminolevulinic acid squamous intraepithelial lesions |
| title | Clinical research of photodynamic therapy with 5-ALA for cervical intraepithelial neoplasms: from preliminary studies to current developments |
| title_full | Clinical research of photodynamic therapy with 5-ALA for cervical intraepithelial neoplasms: from preliminary studies to current developments |
| title_fullStr | Clinical research of photodynamic therapy with 5-ALA for cervical intraepithelial neoplasms: from preliminary studies to current developments |
| title_full_unstemmed | Clinical research of photodynamic therapy with 5-ALA for cervical intraepithelial neoplasms: from preliminary studies to current developments |
| title_short | Clinical research of photodynamic therapy with 5-ALA for cervical intraepithelial neoplasms: from preliminary studies to current developments |
| title_sort | clinical research of photodynamic therapy with 5 ala for cervical intraepithelial neoplasms from preliminary studies to current developments |
| topic | cervical intraepithelial neoplasia photodynamic therapy human papillomavirus 5-aminolevulinic acid squamous intraepithelial lesions |
| url | https://www.pdt-journal.com/jour/article/view/720 |
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