RNA methyltransferase NSUN2-mediated m5C methylation promotes Cr(VI)-induced malignant transformation and lung cancer by accelerating metabolism reprogramming

RNA methyltransferase NSUN2-mediated m5C methylation promotes Cr(VI)-induced malignant transformation and lung cancer by accelerating metabolism reprogramming

Hexavalent chromium [Cr(VI)], one common environmental contaminant, has long been recognized as a carcinogen associated with lung cancer, but roles and mechanisms of Cr(VI)-induced epigenetic dysregulations in carcinogenesis remain to be investigated. In this study, we identified that RNA m5C methyl...

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Bibliographic Details
Main Authors: Rui-Ke Zhang, Yan Li, Fan-Li Sun, Zhi-Hao Zhou, Yun-Xia Xie, Wen-Jing Liu, Wei Wang, Jian-Ge Qiu, Bing-Hua Jiang, Lin Wang
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Environment International
Subjects:
Hexavalent chromium
NSUN2
Cell malignant transformation
Metabolic reprogramming
Tumor growth
Online Access:http://www.sciencedirect.com/science/article/pii/S016041202400641X
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