Immune‐dysregulation harnessing in myeloid neoplasms
Abstract Myeloid malignancies arise in bone marrow microenvironments and shape these microenvironments in favor of malignant development. Immune suppression is one of the most important stages in myeloid leukemia progression. Leukemic clone expansion and immune dysregulation occur simultaneously in...
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Wiley
2024-09-01
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Online Access: | https://doi.org/10.1002/cam4.70152 |
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author | Mohammad Jafar Sharifi Ling Xu Nahid Nasiri Mehnoosh Ashja‐Arvan Hadis Soleimanzadeh Mazdak Ganjalikhani‐Hakemi |
author_facet | Mohammad Jafar Sharifi Ling Xu Nahid Nasiri Mehnoosh Ashja‐Arvan Hadis Soleimanzadeh Mazdak Ganjalikhani‐Hakemi |
author_sort | Mohammad Jafar Sharifi |
collection | DOAJ |
description | Abstract Myeloid malignancies arise in bone marrow microenvironments and shape these microenvironments in favor of malignant development. Immune suppression is one of the most important stages in myeloid leukemia progression. Leukemic clone expansion and immune dysregulation occur simultaneously in bone marrow microenvironments. Complex interactions emerge between normal immune system elements and leukemic clones in the bone marrow. In recent years, researchers have identified several of these pathological interactions. For instance, recent works shows that the secretion of inflammatory cytokines such as tumor necrosis factor‐α (TNF‐α), from bone marrow stromal cells contributes to immune dysregulation and the selective proliferation of JAK2V617F+ clones in myeloproliferative neoplasms. Moreover, inflammasome activation and sterile inflammation result in inflamed microenvironments and the development of myelodysplastic syndromes. Additional immune dysregulations, such as exhaustion of T and NK cells, an increase in regulatory T cells, and impairments in antigen presentation are common findings in myeloid malignancies. In this review, we discuss the role of altered bone marrow microenvironments in the induction of immune dysregulations that accompany myeloid malignancies. We also consider both current and novel therapeutic strategies to restore normal immune system function in the context of myeloid malignancies. |
format | Article |
id | doaj-art-017af456b7084544899aebf49d46513c |
institution | Kabale University |
issn | 2045-7634 |
language | English |
publishDate | 2024-09-01 |
publisher | Wiley |
record_format | Article |
series | Cancer Medicine |
spelling | doaj-art-017af456b7084544899aebf49d46513c2025-02-07T09:08:08ZengWileyCancer Medicine2045-76342024-09-011317n/an/a10.1002/cam4.70152Immune‐dysregulation harnessing in myeloid neoplasmsMohammad Jafar Sharifi0Ling Xu1Nahid Nasiri2Mehnoosh Ashja‐Arvan3Hadis Soleimanzadeh4Mazdak Ganjalikhani‐Hakemi5Division of Laboratory Hematology and Blood Banking, Department of Medical Laboratory Sciences, School of Paramedical Sciences Shiraz University of Medical Sciences Shiraz IranInstitute of Hematology, School of Medicine, Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University Guangzhou ChinaDivision of Laboratory Hematology and Blood Banking, Department of Medical Laboratory Sciences, School of Paramedical Sciences Shiraz University of Medical Sciences Shiraz IranRegenerative and Restorative Medicine Research Center (REMER) Research Institute of Health sciences and Technology (SABITA), Istanbul Medipol University Istanbul TurkeyDivision of Laboratory Hematology and Blood Banking, Department of Medical Laboratory Sciences, School of Paramedical Sciences Shiraz University of Medical Sciences Shiraz IranRegenerative and Restorative Medicine Research Center (REMER) Research Institute of Health sciences and Technology (SABITA), Istanbul Medipol University Istanbul TurkeyAbstract Myeloid malignancies arise in bone marrow microenvironments and shape these microenvironments in favor of malignant development. Immune suppression is one of the most important stages in myeloid leukemia progression. Leukemic clone expansion and immune dysregulation occur simultaneously in bone marrow microenvironments. Complex interactions emerge between normal immune system elements and leukemic clones in the bone marrow. In recent years, researchers have identified several of these pathological interactions. For instance, recent works shows that the secretion of inflammatory cytokines such as tumor necrosis factor‐α (TNF‐α), from bone marrow stromal cells contributes to immune dysregulation and the selective proliferation of JAK2V617F+ clones in myeloproliferative neoplasms. Moreover, inflammasome activation and sterile inflammation result in inflamed microenvironments and the development of myelodysplastic syndromes. Additional immune dysregulations, such as exhaustion of T and NK cells, an increase in regulatory T cells, and impairments in antigen presentation are common findings in myeloid malignancies. In this review, we discuss the role of altered bone marrow microenvironments in the induction of immune dysregulations that accompany myeloid malignancies. We also consider both current and novel therapeutic strategies to restore normal immune system function in the context of myeloid malignancies.https://doi.org/10.1002/cam4.70152acute myeloid leukemiamyelodysplastic syndromemyeloproliferative disorderstumor‐infiltrating immune cells |
spellingShingle | Mohammad Jafar Sharifi Ling Xu Nahid Nasiri Mehnoosh Ashja‐Arvan Hadis Soleimanzadeh Mazdak Ganjalikhani‐Hakemi Immune‐dysregulation harnessing in myeloid neoplasms Cancer Medicine acute myeloid leukemia myelodysplastic syndrome myeloproliferative disorders tumor‐infiltrating immune cells |
title | Immune‐dysregulation harnessing in myeloid neoplasms |
title_full | Immune‐dysregulation harnessing in myeloid neoplasms |
title_fullStr | Immune‐dysregulation harnessing in myeloid neoplasms |
title_full_unstemmed | Immune‐dysregulation harnessing in myeloid neoplasms |
title_short | Immune‐dysregulation harnessing in myeloid neoplasms |
title_sort | immune dysregulation harnessing in myeloid neoplasms |
topic | acute myeloid leukemia myelodysplastic syndrome myeloproliferative disorders tumor‐infiltrating immune cells |
url | https://doi.org/10.1002/cam4.70152 |
work_keys_str_mv | AT mohammadjafarsharifi immunedysregulationharnessinginmyeloidneoplasms AT lingxu immunedysregulationharnessinginmyeloidneoplasms AT nahidnasiri immunedysregulationharnessinginmyeloidneoplasms AT mehnooshashjaarvan immunedysregulationharnessinginmyeloidneoplasms AT hadissoleimanzadeh immunedysregulationharnessinginmyeloidneoplasms AT mazdakganjalikhanihakemi immunedysregulationharnessinginmyeloidneoplasms |