Leptospirosis Presenting with Features of Thrombotic Microangiopathy
Leptospirosis is an exceptionally rare infectious disease in the Republic of Ireland. Leptospirosis can present with or mimic thrombotic microangiopathies (TTP/HUS). A 48-year-old male presented to a peripheral hospital with a short history of diarrhoea, anaemia, hyperbilirubinemia, raised lactate d...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2020/8890719 |
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| author | Chaudhry Adeel Ebad Nabeehah Moollan Adeel Rafi Ahmed Anthony Dorman Colm Magee |
| author_facet | Chaudhry Adeel Ebad Nabeehah Moollan Adeel Rafi Ahmed Anthony Dorman Colm Magee |
| author_sort | Chaudhry Adeel Ebad |
| collection | DOAJ |
| description | Leptospirosis is an exceptionally rare infectious disease in the Republic of Ireland. Leptospirosis can present with or mimic thrombotic microangiopathies (TTP/HUS). A 48-year-old male presented to a peripheral hospital with a short history of diarrhoea, anaemia, hyperbilirubinemia, raised lactate dehydrogenase, thrombocytopenia, and severe acute kidney injury and was transferred to our tertiary care kidney centre. A form of acute thrombotic microangiopathy (TMA) was suspected. However, no schistocytes were seen on the blood film, and the reticulocyte count was depressed. A kidney biopsy was performed before initiating any potential treatment which revealed acute interstitial nephritis (AIN). Leptospirosis was considered and subsequently serologically confirmed. The patient was managed with antimicrobials and supportive therapy. Acute kidney injury is common in leptospirosis and is often due to AIN. Initial presentation can mimic TMA; however, a differential diagnosis of leptospirosis should be considered even in nonendemic areas due to re-emergence of the disease. |
| format | Article |
| id | doaj-art-01791c75fcd44411a4e2b166ebbeafcd |
| institution | Kabale University |
| issn | 2090-6641 2090-665X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Nephrology |
| spelling | doaj-art-01791c75fcd44411a4e2b166ebbeafcd2025-02-03T06:05:39ZengWileyCase Reports in Nephrology2090-66412090-665X2020-01-01202010.1155/2020/88907198890719Leptospirosis Presenting with Features of Thrombotic MicroangiopathyChaudhry Adeel Ebad0Nabeehah Moollan1Adeel Rafi Ahmed2Anthony Dorman3Colm Magee4Department of Nephrology, Beaumont Hospital, Dublin, IrelandDepartment of Nephrology, Beaumont Hospital, Dublin, IrelandDepartment of Nephrology, Beaumont Hospital, Dublin, IrelandDepartment of Pathology, Beaumont Hospital, Dublin, IrelandDepartment of Nephrology, Beaumont Hospital, Dublin, IrelandLeptospirosis is an exceptionally rare infectious disease in the Republic of Ireland. Leptospirosis can present with or mimic thrombotic microangiopathies (TTP/HUS). A 48-year-old male presented to a peripheral hospital with a short history of diarrhoea, anaemia, hyperbilirubinemia, raised lactate dehydrogenase, thrombocytopenia, and severe acute kidney injury and was transferred to our tertiary care kidney centre. A form of acute thrombotic microangiopathy (TMA) was suspected. However, no schistocytes were seen on the blood film, and the reticulocyte count was depressed. A kidney biopsy was performed before initiating any potential treatment which revealed acute interstitial nephritis (AIN). Leptospirosis was considered and subsequently serologically confirmed. The patient was managed with antimicrobials and supportive therapy. Acute kidney injury is common in leptospirosis and is often due to AIN. Initial presentation can mimic TMA; however, a differential diagnosis of leptospirosis should be considered even in nonendemic areas due to re-emergence of the disease.http://dx.doi.org/10.1155/2020/8890719 |
| spellingShingle | Chaudhry Adeel Ebad Nabeehah Moollan Adeel Rafi Ahmed Anthony Dorman Colm Magee Leptospirosis Presenting with Features of Thrombotic Microangiopathy Case Reports in Nephrology |
| title | Leptospirosis Presenting with Features of Thrombotic Microangiopathy |
| title_full | Leptospirosis Presenting with Features of Thrombotic Microangiopathy |
| title_fullStr | Leptospirosis Presenting with Features of Thrombotic Microangiopathy |
| title_full_unstemmed | Leptospirosis Presenting with Features of Thrombotic Microangiopathy |
| title_short | Leptospirosis Presenting with Features of Thrombotic Microangiopathy |
| title_sort | leptospirosis presenting with features of thrombotic microangiopathy |
| url | http://dx.doi.org/10.1155/2020/8890719 |
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