Comparison Of Diacerein-Ginger With Diacerein Alone In Treating Knee Osteoarthritis
Objective: To compare clinical efficacy of diacerein-ginger with diacerein alone in treating knee osteoarthritis. Duration and place of study: It was a randomized clinical trial conducted from 21st September 2018 to 31stMarch 2019, in medical OPD of a private hospital in Karachi. Methodology: 60 di...
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| Format: | Article |
| Language: | English |
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Bahria Univerisy Health Sciences, Campus Karachi
2019-12-01
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| Series: | Journal of Bahria University Medical and Dental College |
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| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/403 |
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| author | Mehtab Munir Shahid Mustafa Memon Sajid Abbas Jaffri Khalid Mustafa Memon |
| author_facet | Mehtab Munir Shahid Mustafa Memon Sajid Abbas Jaffri Khalid Mustafa Memon |
| author_sort | Mehtab Munir |
| collection | DOAJ |
| description |
Objective: To compare clinical efficacy of diacerein-ginger with diacerein alone in treating knee osteoarthritis.
Duration and place of study: It was a randomized clinical trial conducted from 21st September 2018 to 31stMarch 2019,
in medical OPD of a private hospital in Karachi.
Methodology: 60 diagnosed patients of knee osteoarthritis were included in this study. Male and female patients 50 years
of age, fulfilling the inclusion criteria and after written informed consent experienced a wash-out period of 72 hours. These
patients were systematically randomized into 2 groups each having 30 members. Group A received capsule Diacerein 50mg
+ capsule Ginger 550 mg twice daily and group B received capsule Diacerein 50mg twice daily, for 12 weeks. Parameters
checked at 0, 6 and 12 weeks were: Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, pain at
rest and movement (Visual Analogue Scale). Comparison of the two groups was done by independent t-test.
Results: Among 60 patients; 20 (33.33 %) were males and 40 (66.66%) were females. 4 patients in group A and 4 in B,
dropped out during the study. Comparison of group A with group B in WOMAC and pain (at rest and movement) scores
showed insignificant difference at day 0 before prescription of the drugs. However comparison showed highly significant
difference (P-value < 0.001) between the two groups in WOMAC, pain at rest and movement scores at the end of 6th and
12th weeks of intervention.
Conclusion: Diacerein-Ginger is clinically more efficacious for management of knee OA than Diacerein alone.
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| format | Article |
| id | doaj-art-016ff2cb4b7e463e92296ab38bcc9337 |
| institution | DOAJ |
| issn | 2220-7562 2617-9482 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Bahria Univerisy Health Sciences, Campus Karachi |
| record_format | Article |
| series | Journal of Bahria University Medical and Dental College |
| spelling | doaj-art-016ff2cb4b7e463e92296ab38bcc93372025-08-20T03:10:58ZengBahria Univerisy Health Sciences, Campus KarachiJournal of Bahria University Medical and Dental College2220-75622617-94822019-12-019410.51985/JBUMDC2019096Comparison Of Diacerein-Ginger With Diacerein Alone In Treating Knee OsteoarthritisMehtab MunirShahid Mustafa MemonSajid Abbas JaffriKhalid Mustafa Memon Objective: To compare clinical efficacy of diacerein-ginger with diacerein alone in treating knee osteoarthritis. Duration and place of study: It was a randomized clinical trial conducted from 21st September 2018 to 31stMarch 2019, in medical OPD of a private hospital in Karachi. Methodology: 60 diagnosed patients of knee osteoarthritis were included in this study. Male and female patients 50 years of age, fulfilling the inclusion criteria and after written informed consent experienced a wash-out period of 72 hours. These patients were systematically randomized into 2 groups each having 30 members. Group A received capsule Diacerein 50mg + capsule Ginger 550 mg twice daily and group B received capsule Diacerein 50mg twice daily, for 12 weeks. Parameters checked at 0, 6 and 12 weeks were: Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, pain at rest and movement (Visual Analogue Scale). Comparison of the two groups was done by independent t-test. Results: Among 60 patients; 20 (33.33 %) were males and 40 (66.66%) were females. 4 patients in group A and 4 in B, dropped out during the study. Comparison of group A with group B in WOMAC and pain (at rest and movement) scores showed insignificant difference at day 0 before prescription of the drugs. However comparison showed highly significant difference (P-value < 0.001) between the two groups in WOMAC, pain at rest and movement scores at the end of 6th and 12th weeks of intervention. Conclusion: Diacerein-Ginger is clinically more efficacious for management of knee OA than Diacerein alone. https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/403knee, osteoarthritis, ginger, diacerein, WOMAC score, pain score |
| spellingShingle | Mehtab Munir Shahid Mustafa Memon Sajid Abbas Jaffri Khalid Mustafa Memon Comparison Of Diacerein-Ginger With Diacerein Alone In Treating Knee Osteoarthritis Journal of Bahria University Medical and Dental College knee, osteoarthritis, ginger, diacerein, WOMAC score, pain score |
| title | Comparison Of Diacerein-Ginger With Diacerein Alone In Treating Knee Osteoarthritis |
| title_full | Comparison Of Diacerein-Ginger With Diacerein Alone In Treating Knee Osteoarthritis |
| title_fullStr | Comparison Of Diacerein-Ginger With Diacerein Alone In Treating Knee Osteoarthritis |
| title_full_unstemmed | Comparison Of Diacerein-Ginger With Diacerein Alone In Treating Knee Osteoarthritis |
| title_short | Comparison Of Diacerein-Ginger With Diacerein Alone In Treating Knee Osteoarthritis |
| title_sort | comparison of diacerein ginger with diacerein alone in treating knee osteoarthritis |
| topic | knee, osteoarthritis, ginger, diacerein, WOMAC score, pain score |
| url | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/403 |
| work_keys_str_mv | AT mehtabmunir comparisonofdiacereingingerwithdiacereinaloneintreatingkneeosteoarthritis AT shahidmustafamemon comparisonofdiacereingingerwithdiacereinaloneintreatingkneeosteoarthritis AT sajidabbasjaffri comparisonofdiacereingingerwithdiacereinaloneintreatingkneeosteoarthritis AT khalidmustafamemon comparisonofdiacereingingerwithdiacereinaloneintreatingkneeosteoarthritis |