Comparison Of Diacerein-Ginger With Diacerein Alone In Treating Knee Osteoarthritis
Objective: To compare clinical efficacy of diacerein-ginger with diacerein alone in treating knee osteoarthritis. Duration and place of study: It was a randomized clinical trial conducted from 21st September 2018 to 31stMarch 2019, in medical OPD of a private hospital in Karachi. Methodology: 60 di...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bahria Univerisy Health Sciences, Campus Karachi
2019-12-01
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| Series: | Journal of Bahria University Medical and Dental College |
| Subjects: | |
| Online Access: | https://jbumdc.bahria.edu.pk/index.php/ojs/article/view/403 |
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| Summary: | Objective: To compare clinical efficacy of diacerein-ginger with diacerein alone in treating knee osteoarthritis.
Duration and place of study: It was a randomized clinical trial conducted from 21st September 2018 to 31stMarch 2019,
in medical OPD of a private hospital in Karachi.
Methodology: 60 diagnosed patients of knee osteoarthritis were included in this study. Male and female patients 50 years
of age, fulfilling the inclusion criteria and after written informed consent experienced a wash-out period of 72 hours. These
patients were systematically randomized into 2 groups each having 30 members. Group A received capsule Diacerein 50mg
+ capsule Ginger 550 mg twice daily and group B received capsule Diacerein 50mg twice daily, for 12 weeks. Parameters
checked at 0, 6 and 12 weeks were: Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, pain at
rest and movement (Visual Analogue Scale). Comparison of the two groups was done by independent t-test.
Results: Among 60 patients; 20 (33.33 %) were males and 40 (66.66%) were females. 4 patients in group A and 4 in B,
dropped out during the study. Comparison of group A with group B in WOMAC and pain (at rest and movement) scores
showed insignificant difference at day 0 before prescription of the drugs. However comparison showed highly significant
difference (P-value < 0.001) between the two groups in WOMAC, pain at rest and movement scores at the end of 6th and
12th weeks of intervention.
Conclusion: Diacerein-Ginger is clinically more efficacious for management of knee OA than Diacerein alone.
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| ISSN: | 2220-7562 2617-9482 |