Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease
The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis. We evaluated the effect of AST-120 on dialysis initiation and its potential to improve survival in patients with chronic kidney disease. The present retrospective pair-matched stud...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2012/376128 |
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| author | Shingo Hatakeyama Hayato Yamamoto Akiko Okamoto Kengo Imanishi Noriko Tokui Teppei Okamoto Yuichiro Suzuki Naoaki Sugiyama Atsushi Imai Shigemasa Kudo Takahiro Yoneyama Yasuhiro Hashimoto Takuya Koie Noritaka Kaminura Hisao Saitoh Tomihisa Funyu Chikara Ohyama |
| author_facet | Shingo Hatakeyama Hayato Yamamoto Akiko Okamoto Kengo Imanishi Noriko Tokui Teppei Okamoto Yuichiro Suzuki Naoaki Sugiyama Atsushi Imai Shigemasa Kudo Takahiro Yoneyama Yasuhiro Hashimoto Takuya Koie Noritaka Kaminura Hisao Saitoh Tomihisa Funyu Chikara Ohyama |
| author_sort | Shingo Hatakeyama |
| collection | DOAJ |
| description | The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis. We evaluated the effect of AST-120 on dialysis initiation and its potential to improve survival in patients with chronic kidney disease. The present retrospective pair-matched study included 560 patients, grouped according to whether or not they received AST-120 before dialysis (AST-120 and non-AST-120 groups). The cumulative dialysis initiation free rate and survival rate were compared by the Kaplan-Meier method. Multivariate analysis was used to determine the impact of AST-120 on dialysis initiation. Our results showed significant differences in the 12- and 24-month dialysis initiation free rate (P<0.001), although no significant difference was observed in the survival rate between the two groups. In conclusion, AST-120 delays dialysis initiation in chronic kidney disease (CKD) patients but has no effect on survival. AST-120 is an effective therapy for delaying the progression of CKD. |
| format | Article |
| id | doaj-art-016ea86efcfd450ebdc698fb31433108 |
| institution | OA Journals |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-016ea86efcfd450ebdc698fb314331082025-08-20T02:03:13ZengWileyInternational Journal of Nephrology2090-214X2090-21582012-01-01201210.1155/2012/376128376128Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney DiseaseShingo Hatakeyama0Hayato Yamamoto1Akiko Okamoto2Kengo Imanishi3Noriko Tokui4Teppei Okamoto5Yuichiro Suzuki6Naoaki Sugiyama7Atsushi Imai8Shigemasa Kudo9Takahiro Yoneyama10Yasuhiro Hashimoto11Takuya Koie12Noritaka Kaminura13Hisao Saitoh14Tomihisa Funyu15Chikara Ohyama16Department of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki 036-8562, JapanDepartment of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, JapanDepartment of Urology, Oyokyo Kidney Research Institute, Hirosaki 036-8243, JapanDepartment of Urology, Oyokyo Kidney Research Institute, Hirosaki 036-8243, JapanDepartment of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, JapanDepartment of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, JapanDepartment of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, JapanDepartment of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, JapanDepartment of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, JapanDepartment of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, JapanDepartment of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, JapanDepartment of Urology, Oyokyo Kidney Research Institute, Hirosaki 036-8243, JapanDepartment of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, JapanDepartment of Urology, Hirosaki University Graduate School of Medicine, Hirosaki 036-8562, JapanDepartment of Urology, Oyokyo Kidney Research Institute, Hirosaki 036-8243, JapanDepartment of Urology, Oyokyo Kidney Research Institute, Hirosaki 036-8243, JapanDepartment of Advanced Transplant and Regenerative Medicine, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki 036-8562, JapanThe oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis. We evaluated the effect of AST-120 on dialysis initiation and its potential to improve survival in patients with chronic kidney disease. The present retrospective pair-matched study included 560 patients, grouped according to whether or not they received AST-120 before dialysis (AST-120 and non-AST-120 groups). The cumulative dialysis initiation free rate and survival rate were compared by the Kaplan-Meier method. Multivariate analysis was used to determine the impact of AST-120 on dialysis initiation. Our results showed significant differences in the 12- and 24-month dialysis initiation free rate (P<0.001), although no significant difference was observed in the survival rate between the two groups. In conclusion, AST-120 delays dialysis initiation in chronic kidney disease (CKD) patients but has no effect on survival. AST-120 is an effective therapy for delaying the progression of CKD.http://dx.doi.org/10.1155/2012/376128 |
| spellingShingle | Shingo Hatakeyama Hayato Yamamoto Akiko Okamoto Kengo Imanishi Noriko Tokui Teppei Okamoto Yuichiro Suzuki Naoaki Sugiyama Atsushi Imai Shigemasa Kudo Takahiro Yoneyama Yasuhiro Hashimoto Takuya Koie Noritaka Kaminura Hisao Saitoh Tomihisa Funyu Chikara Ohyama Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease International Journal of Nephrology |
| title | Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease |
| title_full | Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease |
| title_fullStr | Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease |
| title_full_unstemmed | Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease |
| title_short | Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease |
| title_sort | effect of an oral adsorbent ast 120 on dialysis initiation and survival in patients with chronic kidney disease |
| url | http://dx.doi.org/10.1155/2012/376128 |
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