Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage
Inner ear hair cells are mechanosensory receptors that perceive mechanical sound and help to decode the sound in order to understand spoken language. Exposure to intense noise may result in the damage to the inner ear hair cells, causing noise-induced hearing loss (NIHL). Particularly, the outer hai...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2018/3170801 |
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| author | Muhammad Waqas Song Gao Iram-us-Salam Muhammad Kazim Ali Yongming Ma Wenyan Li |
| author_facet | Muhammad Waqas Song Gao Iram-us-Salam Muhammad Kazim Ali Yongming Ma Wenyan Li |
| author_sort | Muhammad Waqas |
| collection | DOAJ |
| description | Inner ear hair cells are mechanosensory receptors that perceive mechanical sound and help to decode the sound in order to understand spoken language. Exposure to intense noise may result in the damage to the inner ear hair cells, causing noise-induced hearing loss (NIHL). Particularly, the outer hair cells are the first and the most affected cells in NIHL. After acoustic trauma, hair cells lose their structural integrity and initiate a self-deterioration process due to the oxidative stress. The activation of different cellular death pathways leads to complete hair cell death. This review specifically presents the current understanding of the mechanism exists behind the loss of inner ear hair cell in the auditory portion after noise-induced trauma. The article also explains the recent hair cell protection strategies to prevent the damage and restore hearing function in mammals. |
| format | Article |
| id | doaj-art-016d31c91a154166b659ae5328a36dd5 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-016d31c91a154166b659ae5328a36dd52025-08-20T03:55:27ZengWileyNeural Plasticity2090-59041687-54432018-01-01201810.1155/2018/31708013170801Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear DamageMuhammad Waqas0Song Gao1Iram-us-Salam2Muhammad Kazim Ali3Yongming Ma4Wenyan Li5Department of Biotechnology, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi, PakistanDepartment of Otolaryngology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang 212002, ChinaDepartment of Biotechnology, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi, PakistanDepartment of Biotechnology, Federal Urdu University of Arts, Science and Technology, Gulshan-e-Iqbal Campus, Karachi, PakistanDepartment of Otolaryngology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang 212002, ChinaENT Institute and Department of Otorhinolaryngology of the Affiliated Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, ChinaInner ear hair cells are mechanosensory receptors that perceive mechanical sound and help to decode the sound in order to understand spoken language. Exposure to intense noise may result in the damage to the inner ear hair cells, causing noise-induced hearing loss (NIHL). Particularly, the outer hair cells are the first and the most affected cells in NIHL. After acoustic trauma, hair cells lose their structural integrity and initiate a self-deterioration process due to the oxidative stress. The activation of different cellular death pathways leads to complete hair cell death. This review specifically presents the current understanding of the mechanism exists behind the loss of inner ear hair cell in the auditory portion after noise-induced trauma. The article also explains the recent hair cell protection strategies to prevent the damage and restore hearing function in mammals.http://dx.doi.org/10.1155/2018/3170801 |
| spellingShingle | Muhammad Waqas Song Gao Iram-us-Salam Muhammad Kazim Ali Yongming Ma Wenyan Li Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage Neural Plasticity |
| title | Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage |
| title_full | Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage |
| title_fullStr | Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage |
| title_full_unstemmed | Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage |
| title_short | Inner Ear Hair Cell Protection in Mammals against the Noise-Induced Cochlear Damage |
| title_sort | inner ear hair cell protection in mammals against the noise induced cochlear damage |
| url | http://dx.doi.org/10.1155/2018/3170801 |
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