Atherogenic Index of Plasma (AIP) as a Long‐Term Prognostic Factor Following CABG: Unveiling Insights From a Large‐Scale Tertiary Center Registry Analysis
ABSTRACT Background and Aims The role of the atherogenic index of plasma (AIP) in predicting major adverse cerebro‐cardiovascular events (MACCE) after coronary artery bypass grafting (CABG) surgery has not been fully explored. The present study aims to investigate the prognostic value of AIP in pred...
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Wiley
2025-04-01
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| Online Access: | https://doi.org/10.1002/hsr2.70616 |
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| author | Abolfazl Salari Parvin Kalhor Ahmad Vakili‐Basir Houshang Bavandpour Karvane Mina Pashang Mojgan Ghavami Arash Jalali Farshid Alaeddini Farzad Masoudkabir |
| author_facet | Abolfazl Salari Parvin Kalhor Ahmad Vakili‐Basir Houshang Bavandpour Karvane Mina Pashang Mojgan Ghavami Arash Jalali Farshid Alaeddini Farzad Masoudkabir |
| author_sort | Abolfazl Salari |
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| description | ABSTRACT Background and Aims The role of the atherogenic index of plasma (AIP) in predicting major adverse cerebro‐cardiovascular events (MACCE) after coronary artery bypass grafting (CABG) surgery has not been fully explored. The present study aims to investigate the prognostic value of AIP in predicting MACCE and its individual components following CABG. Methods This is a large‐scale retrospective study conducted on patients who underwent isolated CABG. The primary outcomes were all‐cause mortality and MACCE, which included acute coronary syndrome (ACS), Cerebrovascular accident (CVA)/transient ischemia attack (TIA), revascularization, and all‐cause mortality. Proportional Hazard (PH) Cox regression, considering stabilized Inverse probability weightings (IPW), was conducted after verifying the PH assumption. Results Totally, 23,432 patients analyzed with median 111.4‐month follow‐up duration. After weighting all variables, a higher AIP was associated with a significantly increased risk of MACCE (HR = 1.05; 95% CI: 1.01–1.09; p = 0.006). Furthermore, AIP was a significant predictor of the risk of revascularization (HR = 1.15; 95% CI: 1.01–1.30; p = 0.034) and ACS (HR = 1.09; 95% CI: 1.01–1.17; p = 0.020). However, AIP couldn't be a prognostic factor for all‐cause mortality and CVA. Conclusion AIP predicts MACCE, revascularization, and ACS after CABG, serving as a readily accessible prognostic factor. |
| format | Article |
| id | doaj-art-01625b8974eb499ba26ca5ffa0d85e9b |
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| issn | 2398-8835 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
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| series | Health Science Reports |
| spelling | doaj-art-01625b8974eb499ba26ca5ffa0d85e9b2025-08-20T01:48:34ZengWileyHealth Science Reports2398-88352025-04-0184n/an/a10.1002/hsr2.70616Atherogenic Index of Plasma (AIP) as a Long‐Term Prognostic Factor Following CABG: Unveiling Insights From a Large‐Scale Tertiary Center Registry AnalysisAbolfazl Salari0Parvin Kalhor1Ahmad Vakili‐Basir2Houshang Bavandpour Karvane3Mina Pashang4Mojgan Ghavami5Arash Jalali6Farshid Alaeddini7Farzad Masoudkabir8Tehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran IranTehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran IranTehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran IranTehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran IranTehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran IranTehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran IranDepartment of Epidemiology and Biostatistics, School of Public Health Tehran University of Medical Sciences Tehran IranTehran Heart Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran IranCardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute Tehran University of Medical Sciences Tehran IranABSTRACT Background and Aims The role of the atherogenic index of plasma (AIP) in predicting major adverse cerebro‐cardiovascular events (MACCE) after coronary artery bypass grafting (CABG) surgery has not been fully explored. The present study aims to investigate the prognostic value of AIP in predicting MACCE and its individual components following CABG. Methods This is a large‐scale retrospective study conducted on patients who underwent isolated CABG. The primary outcomes were all‐cause mortality and MACCE, which included acute coronary syndrome (ACS), Cerebrovascular accident (CVA)/transient ischemia attack (TIA), revascularization, and all‐cause mortality. Proportional Hazard (PH) Cox regression, considering stabilized Inverse probability weightings (IPW), was conducted after verifying the PH assumption. Results Totally, 23,432 patients analyzed with median 111.4‐month follow‐up duration. After weighting all variables, a higher AIP was associated with a significantly increased risk of MACCE (HR = 1.05; 95% CI: 1.01–1.09; p = 0.006). Furthermore, AIP was a significant predictor of the risk of revascularization (HR = 1.15; 95% CI: 1.01–1.30; p = 0.034) and ACS (HR = 1.09; 95% CI: 1.01–1.17; p = 0.020). However, AIP couldn't be a prognostic factor for all‐cause mortality and CVA. Conclusion AIP predicts MACCE, revascularization, and ACS after CABG, serving as a readily accessible prognostic factor.https://doi.org/10.1002/hsr2.70616atherogenic index of plasmacoronary artery diseasecoronary artery bypass graftmajor cardiovascular adverse event |
| spellingShingle | Abolfazl Salari Parvin Kalhor Ahmad Vakili‐Basir Houshang Bavandpour Karvane Mina Pashang Mojgan Ghavami Arash Jalali Farshid Alaeddini Farzad Masoudkabir Atherogenic Index of Plasma (AIP) as a Long‐Term Prognostic Factor Following CABG: Unveiling Insights From a Large‐Scale Tertiary Center Registry Analysis Health Science Reports atherogenic index of plasma coronary artery disease coronary artery bypass graft major cardiovascular adverse event |
| title | Atherogenic Index of Plasma (AIP) as a Long‐Term Prognostic Factor Following CABG: Unveiling Insights From a Large‐Scale Tertiary Center Registry Analysis |
| title_full | Atherogenic Index of Plasma (AIP) as a Long‐Term Prognostic Factor Following CABG: Unveiling Insights From a Large‐Scale Tertiary Center Registry Analysis |
| title_fullStr | Atherogenic Index of Plasma (AIP) as a Long‐Term Prognostic Factor Following CABG: Unveiling Insights From a Large‐Scale Tertiary Center Registry Analysis |
| title_full_unstemmed | Atherogenic Index of Plasma (AIP) as a Long‐Term Prognostic Factor Following CABG: Unveiling Insights From a Large‐Scale Tertiary Center Registry Analysis |
| title_short | Atherogenic Index of Plasma (AIP) as a Long‐Term Prognostic Factor Following CABG: Unveiling Insights From a Large‐Scale Tertiary Center Registry Analysis |
| title_sort | atherogenic index of plasma aip as a long term prognostic factor following cabg unveiling insights from a large scale tertiary center registry analysis |
| topic | atherogenic index of plasma coronary artery disease coronary artery bypass graft major cardiovascular adverse event |
| url | https://doi.org/10.1002/hsr2.70616 |
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