The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease
Background. Perirenal fat (PRF) has multiple effects on the kidney through its physical structure and adipocytokine-secreting ability. The present study explored the relationship between PRF thickness and the onset and progression of albuminuria in patients with diabetes. Methods. In the cross-secti...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/2550744 |
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| author | Hongtu Hu Wei Liang Zongwei Zhang Zikang Liu Fan Chu Yan Bao Jialu Ran Guohua Ding |
| author_facet | Hongtu Hu Wei Liang Zongwei Zhang Zikang Liu Fan Chu Yan Bao Jialu Ran Guohua Ding |
| author_sort | Hongtu Hu |
| collection | DOAJ |
| description | Background. Perirenal fat (PRF) has multiple effects on the kidney through its physical structure and adipocytokine-secreting ability. The present study explored the relationship between PRF thickness and the onset and progression of albuminuria in patients with diabetes. Methods. In the cross-sectional analysis, we screened 959 patients from 8764 subjects with type 2 diabetes mellitus (T2DM) who met the inclusion criteria and measured their perirenal fat thickness (PFT) using color Doppler ultrasound. A group of laboratory indexes were included in the analysis models. In a longitudinal study, a total of 218 patients with a baseline UACR <30 mg/g were included in the follow-up study. Results. In a cross-sectional analysis, patients with diabetes and higher PFT presented with higher albuminuria. Multiple logistic regression analysis indicated that PFT was an independent risk factor for the degree of albuminuria in patients with T2DM (odds ratio = 4.186, 95%CI: 2.290–7.653, P < 0.001). In a longitudinal study, 218 albuminuria-free patients with T2DM at the baseline were followed up for a mean of 12.3 months. Based on the cutoff value from the ROC diagnostic test in the cross-sectional study, patients were divided into two groups: higher PFT (H-PFT) and lower PFT (L-PFT). Kaplan–Meier survival curve analysis showed that H-PFT was associated with a higher incidence of albuminuria than L-PFT (log-rank test, χ2 = 4.522, P = 0.033). Cox regression analysis showed that PFT was a risk factor for the earlier onset of albuminuria (hazard ratio 2.83, 95% CI: 1.34–4.88, P < 0.001). Conclusions. PRF evaluated by color Doppler ultrasound is an easy and reliable tool for predicting the onset and progression of albuminuria in patients with T2DM. |
| format | Article |
| id | doaj-art-015ff508cdc846c7a8de35b8deba71b8 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-015ff508cdc846c7a8de35b8deba71b82025-02-03T01:00:44ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/2550744The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney DiseaseHongtu Hu0Wei Liang1Zongwei Zhang2Zikang Liu3Fan Chu4Yan Bao5Jialu Ran6Guohua Ding7Division of NephrologyDivision of NephrologyDivision of NephrologyDivision of NephrologyDivision of NephrologyDivision of EndocrinologyDepartment of Biostatistics and BioinformaticsDivision of NephrologyBackground. Perirenal fat (PRF) has multiple effects on the kidney through its physical structure and adipocytokine-secreting ability. The present study explored the relationship between PRF thickness and the onset and progression of albuminuria in patients with diabetes. Methods. In the cross-sectional analysis, we screened 959 patients from 8764 subjects with type 2 diabetes mellitus (T2DM) who met the inclusion criteria and measured their perirenal fat thickness (PFT) using color Doppler ultrasound. A group of laboratory indexes were included in the analysis models. In a longitudinal study, a total of 218 patients with a baseline UACR <30 mg/g were included in the follow-up study. Results. In a cross-sectional analysis, patients with diabetes and higher PFT presented with higher albuminuria. Multiple logistic regression analysis indicated that PFT was an independent risk factor for the degree of albuminuria in patients with T2DM (odds ratio = 4.186, 95%CI: 2.290–7.653, P < 0.001). In a longitudinal study, 218 albuminuria-free patients with T2DM at the baseline were followed up for a mean of 12.3 months. Based on the cutoff value from the ROC diagnostic test in the cross-sectional study, patients were divided into two groups: higher PFT (H-PFT) and lower PFT (L-PFT). Kaplan–Meier survival curve analysis showed that H-PFT was associated with a higher incidence of albuminuria than L-PFT (log-rank test, χ2 = 4.522, P = 0.033). Cox regression analysis showed that PFT was a risk factor for the earlier onset of albuminuria (hazard ratio 2.83, 95% CI: 1.34–4.88, P < 0.001). Conclusions. PRF evaluated by color Doppler ultrasound is an easy and reliable tool for predicting the onset and progression of albuminuria in patients with T2DM.http://dx.doi.org/10.1155/2022/2550744 |
| spellingShingle | Hongtu Hu Wei Liang Zongwei Zhang Zikang Liu Fan Chu Yan Bao Jialu Ran Guohua Ding The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease International Journal of Endocrinology |
| title | The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease |
| title_full | The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease |
| title_fullStr | The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease |
| title_full_unstemmed | The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease |
| title_short | The Utility of Perirenal Fat in Determining the Risk of Onset and Progression of Diabetic Kidney Disease |
| title_sort | utility of perirenal fat in determining the risk of onset and progression of diabetic kidney disease |
| url | http://dx.doi.org/10.1155/2022/2550744 |
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