Bilateral limbal stem cell deficiency managed by a two-stage approach of K-pro and minor salivary gland transplantation
A 25-year-old one-eyed male presented with a complaint of diminution of vision in the right eye (RE) which was gradually progressive for 2 years and associated with redness, foreign body sensation, and pain. On examination, he had conjunctival hyperemia, conjuctivization of the entire cornea, and co...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-07-01
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| Series: | Journal of Clinical Ophthalmology and Research |
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| Online Access: | https://journals.lww.com/10.4103/jcor.jcor_45_25 |
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| author | Akshay Jawaharlal Bhandari Ananya Jena Ankita Chandrashekhar Shirude |
| author_facet | Akshay Jawaharlal Bhandari Ananya Jena Ankita Chandrashekhar Shirude |
| author_sort | Akshay Jawaharlal Bhandari |
| collection | DOAJ |
| description | A 25-year-old one-eyed male presented with a complaint of diminution of vision in the right eye (RE) which was gradually progressive for 2 years and associated with redness, foreign body sensation, and pain. On examination, he had conjunctival hyperemia, conjuctivization of the entire cornea, and complete loss of palisades of Vogt in both eyes with irregular fluorescein staining. Schirmer test suggested moderate dry eye. A provisional diagnosis of BE severe limbal stem cell deficiency (LSCD) was made and RE Type I keratoprosthesis (K-pro) was planned followed by minor salivary gland transplantation. On 2-week follow-up, RE vision improved to finger counting 4 m and tear film status improved as well. K-pro proved to be a novel method in treating our case of bilateral severe LSCD and the use of minor salivary gland transplantation acted as an adjunct in treating our patient’s underlying dry eye. |
| format | Article |
| id | doaj-art-015f7fbc621849f49d87e7ef84092024 |
| institution | Kabale University |
| issn | 2320-3897 2320-3900 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical Ophthalmology and Research |
| spelling | doaj-art-015f7fbc621849f49d87e7ef840920242025-08-20T03:40:51ZengWolters Kluwer Medknow PublicationsJournal of Clinical Ophthalmology and Research2320-38972320-39002025-07-0113340440610.4103/jcor.jcor_45_25Bilateral limbal stem cell deficiency managed by a two-stage approach of K-pro and minor salivary gland transplantationAkshay Jawaharlal BhandariAnanya JenaAnkita Chandrashekhar ShirudeA 25-year-old one-eyed male presented with a complaint of diminution of vision in the right eye (RE) which was gradually progressive for 2 years and associated with redness, foreign body sensation, and pain. On examination, he had conjunctival hyperemia, conjuctivization of the entire cornea, and complete loss of palisades of Vogt in both eyes with irregular fluorescein staining. Schirmer test suggested moderate dry eye. A provisional diagnosis of BE severe limbal stem cell deficiency (LSCD) was made and RE Type I keratoprosthesis (K-pro) was planned followed by minor salivary gland transplantation. On 2-week follow-up, RE vision improved to finger counting 4 m and tear film status improved as well. K-pro proved to be a novel method in treating our case of bilateral severe LSCD and the use of minor salivary gland transplantation acted as an adjunct in treating our patient’s underlying dry eye.https://journals.lww.com/10.4103/jcor.jcor_45_25keratoprosthesislimbal stem cell deficiencysalivary gland transplantation |
| spellingShingle | Akshay Jawaharlal Bhandari Ananya Jena Ankita Chandrashekhar Shirude Bilateral limbal stem cell deficiency managed by a two-stage approach of K-pro and minor salivary gland transplantation Journal of Clinical Ophthalmology and Research keratoprosthesis limbal stem cell deficiency salivary gland transplantation |
| title | Bilateral limbal stem cell deficiency managed by a two-stage approach of K-pro and minor salivary gland transplantation |
| title_full | Bilateral limbal stem cell deficiency managed by a two-stage approach of K-pro and minor salivary gland transplantation |
| title_fullStr | Bilateral limbal stem cell deficiency managed by a two-stage approach of K-pro and minor salivary gland transplantation |
| title_full_unstemmed | Bilateral limbal stem cell deficiency managed by a two-stage approach of K-pro and minor salivary gland transplantation |
| title_short | Bilateral limbal stem cell deficiency managed by a two-stage approach of K-pro and minor salivary gland transplantation |
| title_sort | bilateral limbal stem cell deficiency managed by a two stage approach of k pro and minor salivary gland transplantation |
| topic | keratoprosthesis limbal stem cell deficiency salivary gland transplantation |
| url | https://journals.lww.com/10.4103/jcor.jcor_45_25 |
| work_keys_str_mv | AT akshayjawaharlalbhandari bilaterallimbalstemcelldeficiencymanagedbyatwostageapproachofkproandminorsalivaryglandtransplantation AT ananyajena bilaterallimbalstemcelldeficiencymanagedbyatwostageapproachofkproandminorsalivaryglandtransplantation AT ankitachandrashekharshirude bilaterallimbalstemcelldeficiencymanagedbyatwostageapproachofkproandminorsalivaryglandtransplantation |