Noncoding RNA, friend or foe for nephrolithiasis?
Nephrolithiasis is one of the most common diseases in urology, characterized by notable incidence and recurrence rates, leading to significant morbidity and financial burden. Despite its prevalence, the precise mechanisms underlying stone formation remain incompletely understood, thus hindering sign...
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| Format: | Article |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2024.1457319/full |
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| author | Qing Wang Zhenlu Yang Xiaolong Chen Yuanyuan Yang Kehua Jiang |
| author_facet | Qing Wang Zhenlu Yang Xiaolong Chen Yuanyuan Yang Kehua Jiang |
| author_sort | Qing Wang |
| collection | DOAJ |
| description | Nephrolithiasis is one of the most common diseases in urology, characterized by notable incidence and recurrence rates, leading to significant morbidity and financial burden. Despite its prevalence, the precise mechanisms underlying stone formation remain incompletely understood, thus hindering significant advancements in kidney stone management over the past three decades. Investigating the pivotal biological molecules that govern stone formation has consistently been a challenging and high-priority task. A significant portion of mammalian genomes are transcribed into noncoding RNAs (ncRNAs), which have the ability to modulate gene expression and disease progression. They are thus emerging as a novel target class for diagnostics and pharmaceutical exploration. In recent years, the role of ncRNAs in stone formation has attracted burgeoning attention. They have been found to influence stone formation by regulating ion transportation, oxidative stress injury, inflammation, osteoblastic transformation, autophagy, and pyroptosis. These findings contributes new perspectives on the pathogenesis of nephrolithiasis. To enhance our understanding of the diagnostic and therapeutic potential of nephrolithiasis-associated ncRNAs, we summarized the expression profiles, biological functions, and clinical significance of these ncRNAs in the current review. |
| format | Article |
| id | doaj-art-015f1915b1d6432a86214922a8aa30f2 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-015f1915b1d6432a86214922a8aa30f22024-11-20T06:26:45ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2024-11-011210.3389/fcell.2024.14573191457319Noncoding RNA, friend or foe for nephrolithiasis?Qing Wang0Zhenlu Yang1Xiaolong Chen2Yuanyuan Yang3Kehua Jiang4Department of Urology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, ChinaDepartment of Radiology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, ChinaDepartment of Urology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, ChinaDepartment of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaDepartment of Urology, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, ChinaNephrolithiasis is one of the most common diseases in urology, characterized by notable incidence and recurrence rates, leading to significant morbidity and financial burden. Despite its prevalence, the precise mechanisms underlying stone formation remain incompletely understood, thus hindering significant advancements in kidney stone management over the past three decades. Investigating the pivotal biological molecules that govern stone formation has consistently been a challenging and high-priority task. A significant portion of mammalian genomes are transcribed into noncoding RNAs (ncRNAs), which have the ability to modulate gene expression and disease progression. They are thus emerging as a novel target class for diagnostics and pharmaceutical exploration. In recent years, the role of ncRNAs in stone formation has attracted burgeoning attention. They have been found to influence stone formation by regulating ion transportation, oxidative stress injury, inflammation, osteoblastic transformation, autophagy, and pyroptosis. These findings contributes new perspectives on the pathogenesis of nephrolithiasis. To enhance our understanding of the diagnostic and therapeutic potential of nephrolithiasis-associated ncRNAs, we summarized the expression profiles, biological functions, and clinical significance of these ncRNAs in the current review.https://www.frontiersin.org/articles/10.3389/fcell.2024.1457319/fullncRNAsnephrolithiasiscalcium oxalatebiomarkerstherapeutic targets |
| spellingShingle | Qing Wang Zhenlu Yang Xiaolong Chen Yuanyuan Yang Kehua Jiang Noncoding RNA, friend or foe for nephrolithiasis? Frontiers in Cell and Developmental Biology ncRNAs nephrolithiasis calcium oxalate biomarkers therapeutic targets |
| title | Noncoding RNA, friend or foe for nephrolithiasis? |
| title_full | Noncoding RNA, friend or foe for nephrolithiasis? |
| title_fullStr | Noncoding RNA, friend or foe for nephrolithiasis? |
| title_full_unstemmed | Noncoding RNA, friend or foe for nephrolithiasis? |
| title_short | Noncoding RNA, friend or foe for nephrolithiasis? |
| title_sort | noncoding rna friend or foe for nephrolithiasis |
| topic | ncRNAs nephrolithiasis calcium oxalate biomarkers therapeutic targets |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2024.1457319/full |
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