Comparing the effects of magnesium sulfate and lidocaine spray on hemodynamic changes caused by laryngoscopy and tracheal intubation: a randomized clinical trial
Abstract Aim This study aims at comparing the impact of Magnesium Sulfate and Lidocaine sprays on hemodynamic changes after laryngoscopy and tracheal intubation. Design This double-blind clinical trial (code IRCT20230719058846N1) was conducted on the patients undergoing elective surgery in the city...
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BMC
2025-02-01
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| Series: | BMC Anesthesiology |
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| Online Access: | https://doi.org/10.1186/s12871-025-02962-x |
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| author | Marzieh khalaji Mohadese Babaie Fatemeh Bayat Mehdi Rezaee Banafsheh Mashak |
| author_facet | Marzieh khalaji Mohadese Babaie Fatemeh Bayat Mehdi Rezaee Banafsheh Mashak |
| author_sort | Marzieh khalaji |
| collection | DOAJ |
| description | Abstract Aim This study aims at comparing the impact of Magnesium Sulfate and Lidocaine sprays on hemodynamic changes after laryngoscopy and tracheal intubation. Design This double-blind clinical trial (code IRCT20230719058846N1) was conducted on the patients undergoing elective surgery in the city of Karaj. Methods A total of 100 patients, aged 18 to 40 years and classified as ASA I or II, who were candidates for elective surgery, were randomly assigned to two equal groups. Prior to intubation, patients received lidocaine spray (5 puffs of Lidocaine 10%) in one group, and magnesium sulfate spray (5 puffs of Magnesium 20%) in the other. Induction of anesthesia was the same in both groups. Patients’ hemodynamic statuses were measured and compared once before the intubation and also 1, 3, 5, 7 and 10 min after it. Results Before the intervention, there was no statistically significant difference between the two groups in terms of demographic and hemodynamic variables (P < 0.05). The results showed that the systolic blood pressure at minutes 3, 5, and 7 was significantly lower among the patients receiving magnesium than those receiving lidocaine (P < 0.05). Other hemodynamic variables were not statistically different between the two groups (P < 0.05). Conclusion Based on the findings of the present study, magnesium sulfate spray is more effective than lidocaine in controlling hemodynamic complications. Therefore, it can be used to reduce hemodynamic complications following intubation. However, it may be associated with tachycardia, which needs to be taken into account. |
| format | Article |
| id | doaj-art-015e8b5a384444ffb71d2c6c943ae379 |
| institution | DOAJ |
| issn | 1471-2253 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Anesthesiology |
| spelling | doaj-art-015e8b5a384444ffb71d2c6c943ae3792025-08-20T02:43:16ZengBMCBMC Anesthesiology1471-22532025-02-012511710.1186/s12871-025-02962-xComparing the effects of magnesium sulfate and lidocaine spray on hemodynamic changes caused by laryngoscopy and tracheal intubation: a randomized clinical trialMarzieh khalaji0Mohadese Babaie1Fatemeh Bayat2Mehdi Rezaee3Banafsheh Mashak4Student Research Committee, School of Medicine, Alborz University of Medical SciencesDepartment of Anesthesiology, School of Allied Medical Sciences, Alborz University of Medical SciencesClinical Research Development Unit (CRDU) of Shahid Rajaei Hospital, Alborz University of Medical SciencesSchool of Medicine, Alborz University of Medical SciencesSchool of Medicine, Alborz University of Medical SciencesAbstract Aim This study aims at comparing the impact of Magnesium Sulfate and Lidocaine sprays on hemodynamic changes after laryngoscopy and tracheal intubation. Design This double-blind clinical trial (code IRCT20230719058846N1) was conducted on the patients undergoing elective surgery in the city of Karaj. Methods A total of 100 patients, aged 18 to 40 years and classified as ASA I or II, who were candidates for elective surgery, were randomly assigned to two equal groups. Prior to intubation, patients received lidocaine spray (5 puffs of Lidocaine 10%) in one group, and magnesium sulfate spray (5 puffs of Magnesium 20%) in the other. Induction of anesthesia was the same in both groups. Patients’ hemodynamic statuses were measured and compared once before the intubation and also 1, 3, 5, 7 and 10 min after it. Results Before the intervention, there was no statistically significant difference between the two groups in terms of demographic and hemodynamic variables (P < 0.05). The results showed that the systolic blood pressure at minutes 3, 5, and 7 was significantly lower among the patients receiving magnesium than those receiving lidocaine (P < 0.05). Other hemodynamic variables were not statistically different between the two groups (P < 0.05). Conclusion Based on the findings of the present study, magnesium sulfate spray is more effective than lidocaine in controlling hemodynamic complications. Therefore, it can be used to reduce hemodynamic complications following intubation. However, it may be associated with tachycardia, which needs to be taken into account.https://doi.org/10.1186/s12871-025-02962-xEndotracheal intubationHemodynamic responseLaryngoscopyLidocaine sprayMagnesium sulfate spray |
| spellingShingle | Marzieh khalaji Mohadese Babaie Fatemeh Bayat Mehdi Rezaee Banafsheh Mashak Comparing the effects of magnesium sulfate and lidocaine spray on hemodynamic changes caused by laryngoscopy and tracheal intubation: a randomized clinical trial BMC Anesthesiology Endotracheal intubation Hemodynamic response Laryngoscopy Lidocaine spray Magnesium sulfate spray |
| title | Comparing the effects of magnesium sulfate and lidocaine spray on hemodynamic changes caused by laryngoscopy and tracheal intubation: a randomized clinical trial |
| title_full | Comparing the effects of magnesium sulfate and lidocaine spray on hemodynamic changes caused by laryngoscopy and tracheal intubation: a randomized clinical trial |
| title_fullStr | Comparing the effects of magnesium sulfate and lidocaine spray on hemodynamic changes caused by laryngoscopy and tracheal intubation: a randomized clinical trial |
| title_full_unstemmed | Comparing the effects of magnesium sulfate and lidocaine spray on hemodynamic changes caused by laryngoscopy and tracheal intubation: a randomized clinical trial |
| title_short | Comparing the effects of magnesium sulfate and lidocaine spray on hemodynamic changes caused by laryngoscopy and tracheal intubation: a randomized clinical trial |
| title_sort | comparing the effects of magnesium sulfate and lidocaine spray on hemodynamic changes caused by laryngoscopy and tracheal intubation a randomized clinical trial |
| topic | Endotracheal intubation Hemodynamic response Laryngoscopy Lidocaine spray Magnesium sulfate spray |
| url | https://doi.org/10.1186/s12871-025-02962-x |
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