Evidence-based prescription for cyclo-oxygenase-2 inhibitors in sports injuries
Healthcare professionals are increasingly under pressure to return athletes to play in the shortest possible time. There is limited choice in providing treatment that speeds up tissue repair, while simultaneously maintaining good quality of healing. Inflammation forms a fundamental part in the proce...
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| Format: | Article |
| Language: | English |
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AOSIS
2015-03-01
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| Series: | South African Family Practice |
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| Online Access: | https://safpj.co.za/index.php/safpj/article/view/4244 |
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| author | D.C. Janse van Rensburg A. Jansen van Rensburg C.C. Grant P. Zondi |
| author_facet | D.C. Janse van Rensburg A. Jansen van Rensburg C.C. Grant P. Zondi |
| author_sort | D.C. Janse van Rensburg |
| collection | DOAJ |
| description | Healthcare professionals are increasingly under pressure to return athletes to play in the shortest possible time. There is limited choice in providing treatment that speeds up tissue repair, while simultaneously maintaining good quality of healing. Inflammation forms a fundamental part in the process of tissue repair. However, excessive inflammation may cause more pain, and limit functional restoration. Although the use of anti-inflammatory treatment in the form of a cyclo-oxygenase-2 inhibitor (coxibs) has been widely recognised as being effective, the potential detrimental effect on tissue repair, as described mainly in animal model studies, needs to be taken into account. The side effects profile on the gastrointestinal tract favour coxibs over non-traditional NSAIDs. The possible effects on the renal and cardiovascular systems also need to be considered. The prescription of coxibs should be pathology and situation specific. There are no clear guidelines on the correct time of administration and the duration of the course, but it seems that the literature is in agreement that they should be administered for a limited time at the lowest effective dose possible. |
| format | Article |
| id | doaj-art-015cc79e509e451796f1e438b3665b4a |
| institution | Kabale University |
| issn | 2078-6190 2078-6204 |
| language | English |
| publishDate | 2015-03-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Family Practice |
| spelling | doaj-art-015cc79e509e451796f1e438b3665b4a2025-08-20T03:47:09ZengAOSISSouth African Family Practice2078-61902078-62042015-03-0157210.4102/safp.v57i2.42443428Evidence-based prescription for cyclo-oxygenase-2 inhibitors in sports injuriesD.C. Janse van Rensburg0A. Jansen van Rensburg1C.C. Grant2P. Zondi3University of PretoriaUniversity of PretoriaUniversity of PretoriaUniversity of PretoriaHealthcare professionals are increasingly under pressure to return athletes to play in the shortest possible time. There is limited choice in providing treatment that speeds up tissue repair, while simultaneously maintaining good quality of healing. Inflammation forms a fundamental part in the process of tissue repair. However, excessive inflammation may cause more pain, and limit functional restoration. Although the use of anti-inflammatory treatment in the form of a cyclo-oxygenase-2 inhibitor (coxibs) has been widely recognised as being effective, the potential detrimental effect on tissue repair, as described mainly in animal model studies, needs to be taken into account. The side effects profile on the gastrointestinal tract favour coxibs over non-traditional NSAIDs. The possible effects on the renal and cardiovascular systems also need to be considered. The prescription of coxibs should be pathology and situation specific. There are no clear guidelines on the correct time of administration and the duration of the course, but it seems that the literature is in agreement that they should be administered for a limited time at the lowest effective dose possible.https://safpj.co.za/index.php/safpj/article/view/4244cyclo-oxygenase-2 inhibitors (coxibs)sports injuriestreatment |
| spellingShingle | D.C. Janse van Rensburg A. Jansen van Rensburg C.C. Grant P. Zondi Evidence-based prescription for cyclo-oxygenase-2 inhibitors in sports injuries South African Family Practice cyclo-oxygenase-2 inhibitors (coxibs) sports injuries treatment |
| title | Evidence-based prescription for cyclo-oxygenase-2 inhibitors in sports injuries |
| title_full | Evidence-based prescription for cyclo-oxygenase-2 inhibitors in sports injuries |
| title_fullStr | Evidence-based prescription for cyclo-oxygenase-2 inhibitors in sports injuries |
| title_full_unstemmed | Evidence-based prescription for cyclo-oxygenase-2 inhibitors in sports injuries |
| title_short | Evidence-based prescription for cyclo-oxygenase-2 inhibitors in sports injuries |
| title_sort | evidence based prescription for cyclo oxygenase 2 inhibitors in sports injuries |
| topic | cyclo-oxygenase-2 inhibitors (coxibs) sports injuries treatment |
| url | https://safpj.co.za/index.php/safpj/article/view/4244 |
| work_keys_str_mv | AT dcjansevanrensburg evidencebasedprescriptionforcyclooxygenase2inhibitorsinsportsinjuries AT ajansenvanrensburg evidencebasedprescriptionforcyclooxygenase2inhibitorsinsportsinjuries AT ccgrant evidencebasedprescriptionforcyclooxygenase2inhibitorsinsportsinjuries AT pzondi evidencebasedprescriptionforcyclooxygenase2inhibitorsinsportsinjuries |