Olfactory epithelium electrical stimulation mitigates memory and synaptic deficits caused by mechanical ventilation
Abstract Mechanical ventilation (MV) causes a wide range of cognitive impairments. Unfortunately, to date, we are lacking knowledge about its underlying neural mechanisms and significant treatment options for the condition. Here, we show that MV-induced memory impairment in rats stems from dysfuncti...
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-96661-9 |
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| author | Sepideh Ghazvineh Morteza Mooziri Alireza Salimi Javad Mirnajafi‑Zadeh Mohammad Reza Raoufy |
| author_facet | Sepideh Ghazvineh Morteza Mooziri Alireza Salimi Javad Mirnajafi‑Zadeh Mohammad Reza Raoufy |
| author_sort | Sepideh Ghazvineh |
| collection | DOAJ |
| description | Abstract Mechanical ventilation (MV) causes a wide range of cognitive impairments. Unfortunately, to date, we are lacking knowledge about its underlying neural mechanisms and significant treatment options for the condition. Here, we show that MV-induced memory impairment in rats stems from dysfunctions in the olfactory bulb-medial prefrontal cortex-ventral hippocampus network and hippocampal synaptic currents imbalance. More importantly, we introduce a novel treatment approach, namely olfactory epithelium electrical stimulation (OEES) that shows promising preclinical results in mitigating the mentioned behavioral and neural disorders caused by MV. These results pave the way for research on non-invasive brain stimulation approaches and introduce the olfactory system as a potential target for treating cognitive or psychiatric disorders induced by MV. |
| format | Article |
| id | doaj-art-015beff5b34d451caa84751fa0625470 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-015beff5b34d451caa84751fa06254702025-08-20T02:12:06ZengNature PortfolioScientific Reports2045-23222025-04-0115111210.1038/s41598-025-96661-9Olfactory epithelium electrical stimulation mitigates memory and synaptic deficits caused by mechanical ventilationSepideh Ghazvineh0Morteza Mooziri1Alireza Salimi2Javad Mirnajafi‑Zadeh3Mohammad Reza Raoufy4Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares UniversityDepartment of Brain and Cognitive Sciences, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECRChronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical SciencesDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares UniversityDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares UniversityAbstract Mechanical ventilation (MV) causes a wide range of cognitive impairments. Unfortunately, to date, we are lacking knowledge about its underlying neural mechanisms and significant treatment options for the condition. Here, we show that MV-induced memory impairment in rats stems from dysfunctions in the olfactory bulb-medial prefrontal cortex-ventral hippocampus network and hippocampal synaptic currents imbalance. More importantly, we introduce a novel treatment approach, namely olfactory epithelium electrical stimulation (OEES) that shows promising preclinical results in mitigating the mentioned behavioral and neural disorders caused by MV. These results pave the way for research on non-invasive brain stimulation approaches and introduce the olfactory system as a potential target for treating cognitive or psychiatric disorders induced by MV.https://doi.org/10.1038/s41598-025-96661-9Mechanical ventilationOlfactory epitheliumElectrical stimulationMemoryLocal field potentialSynaptic current |
| spellingShingle | Sepideh Ghazvineh Morteza Mooziri Alireza Salimi Javad Mirnajafi‑Zadeh Mohammad Reza Raoufy Olfactory epithelium electrical stimulation mitigates memory and synaptic deficits caused by mechanical ventilation Scientific Reports Mechanical ventilation Olfactory epithelium Electrical stimulation Memory Local field potential Synaptic current |
| title | Olfactory epithelium electrical stimulation mitigates memory and synaptic deficits caused by mechanical ventilation |
| title_full | Olfactory epithelium electrical stimulation mitigates memory and synaptic deficits caused by mechanical ventilation |
| title_fullStr | Olfactory epithelium electrical stimulation mitigates memory and synaptic deficits caused by mechanical ventilation |
| title_full_unstemmed | Olfactory epithelium electrical stimulation mitigates memory and synaptic deficits caused by mechanical ventilation |
| title_short | Olfactory epithelium electrical stimulation mitigates memory and synaptic deficits caused by mechanical ventilation |
| title_sort | olfactory epithelium electrical stimulation mitigates memory and synaptic deficits caused by mechanical ventilation |
| topic | Mechanical ventilation Olfactory epithelium Electrical stimulation Memory Local field potential Synaptic current |
| url | https://doi.org/10.1038/s41598-025-96661-9 |
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