Risk factors of development of hepatocellular carcinoma
The aim of review. To draw attention of general practitioners to the risk factors of hepatocellular carcinoma (HCC) development, to define group of patients with high probability of development of this tumor, to outline algorithm of screening diagnostics for patients of high risk group.Original posi...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2009-02-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1592 |
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| author | V. T. Ivashkin M. A. Morozova M. V. Mayevskaya I. A. Sokolina Ye. N. German M. V. Bundina |
| author_facet | V. T. Ivashkin M. A. Morozova M. V. Mayevskaya I. A. Sokolina Ye. N. German M. V. Bundina |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | The aim of review. To draw attention of general practitioners to the risk factors of hepatocellular carcinoma (HCC) development, to define group of patients with high probability of development of this tumor, to outline algorithm of screening diagnostics for patients of high risk group.Original positions of the report. Independent risk factors for HCC development include hepatitis B and C viruses, the level of hepatitis B viral load, the stage of liver cirrhosis, male gender, age over 40 years, alcohol intake and smoking. Patients of high risk group should undergo investigation of alpha-fetoprotein level and abdominal US once per 6 months for early diagnostics of HCC; at detection of any liver lesions further deep investigation including computer and magnetic-resonance tomography, guided biopsy of the lesion is indicated.Conclusion. According to present studies data, morbidity of HCC all over the world steadily grows. High risk group for HCC include patients of male gender over 50 years old (for Caucasian patients) with liver cirrhosis, especially of viral etiology, smoking and consuming alcohol. Prophylaxis of HCC should include prevention of hepatites B and C viruses infection, elimination of hepatotoxic substances, hepatitis B virus vaccination, antiviral therapy for patients with hepatites B and С. Patients from HCC risk groups need to be screened for tumor regularly (once in half a year). Its detection at the early stage allows to start medical actions in time, that helps to increase patients’ survival rate. |
| format | Article |
| id | doaj-art-015a5fae8dd9489db552e80e9e87339c |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2009-02-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-015a5fae8dd9489db552e80e9e87339c2025-02-10T16:14:30ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732009-02-011914151098Risk factors of development of hepatocellular carcinomaV. T. Ivashkin0M. A. Morozova1M. V. Mayevskaya2I. A. Sokolina3Ye. N. German4M. V. Bundina5Московская медицинская академия им. И.М. СеченоваМосковская медицинская академия им. И.М. СеченоваМосковская медицинская академия им. И.М. СеченоваМосковская медицинская академия им. И.М. СеченоваМосковская медицинская академия им. И.М. СеченоваМосковская медицинская академия им. И.М. СеченоваThe aim of review. To draw attention of general practitioners to the risk factors of hepatocellular carcinoma (HCC) development, to define group of patients with high probability of development of this tumor, to outline algorithm of screening diagnostics for patients of high risk group.Original positions of the report. Independent risk factors for HCC development include hepatitis B and C viruses, the level of hepatitis B viral load, the stage of liver cirrhosis, male gender, age over 40 years, alcohol intake and smoking. Patients of high risk group should undergo investigation of alpha-fetoprotein level and abdominal US once per 6 months for early diagnostics of HCC; at detection of any liver lesions further deep investigation including computer and magnetic-resonance tomography, guided biopsy of the lesion is indicated.Conclusion. According to present studies data, morbidity of HCC all over the world steadily grows. High risk group for HCC include patients of male gender over 50 years old (for Caucasian patients) with liver cirrhosis, especially of viral etiology, smoking and consuming alcohol. Prophylaxis of HCC should include prevention of hepatites B and C viruses infection, elimination of hepatotoxic substances, hepatitis B virus vaccination, antiviral therapy for patients with hepatites B and С. Patients from HCC risk groups need to be screened for tumor regularly (once in half a year). Its detection at the early stage allows to start medical actions in time, that helps to increase patients’ survival rate.https://www.gastro-j.ru/jour/article/view/1592hepatocellular carcinomarisk factorsliver cirrhosishepatitis b and c viruses |
| spellingShingle | V. T. Ivashkin M. A. Morozova M. V. Mayevskaya I. A. Sokolina Ye. N. German M. V. Bundina Risk factors of development of hepatocellular carcinoma Российский журнал гастроэнтерологии, гепатологии, колопроктологии hepatocellular carcinoma risk factors liver cirrhosis hepatitis b and c viruses |
| title | Risk factors of development of hepatocellular carcinoma |
| title_full | Risk factors of development of hepatocellular carcinoma |
| title_fullStr | Risk factors of development of hepatocellular carcinoma |
| title_full_unstemmed | Risk factors of development of hepatocellular carcinoma |
| title_short | Risk factors of development of hepatocellular carcinoma |
| title_sort | risk factors of development of hepatocellular carcinoma |
| topic | hepatocellular carcinoma risk factors liver cirrhosis hepatitis b and c viruses |
| url | https://www.gastro-j.ru/jour/article/view/1592 |
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