Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis
Convulsions triggered by fever are the most common type of seizures in childhood, and 20% to 30% of them have recurrence. The prophylactic treatment is still controversial, so we performed a systematic review to find out the effectiveness of continuous phenobarbital and intermittent diazepam compare...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2003-01-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000600001 |
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| _version_ | 1849705005873889280 |
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| author | Masuko Alice Hatsue Castro Aldemar Araujo Santos Gustavo Rocha Atallah Álvaro Nagib Prado Lucila Bizari Fernandes do Carvalho Luciane Bizari Coin de Prado Gilmar Fernandes do |
| author_facet | Masuko Alice Hatsue Castro Aldemar Araujo Santos Gustavo Rocha Atallah Álvaro Nagib Prado Lucila Bizari Fernandes do Carvalho Luciane Bizari Coin de Prado Gilmar Fernandes do |
| author_sort | Masuko Alice Hatsue |
| collection | DOAJ |
| description | Convulsions triggered by fever are the most common type of seizures in childhood, and 20% to 30% of them have recurrence. The prophylactic treatment is still controversial, so we performed a systematic review to find out the effectiveness of continuous phenobarbital and intermittent diazepam compared to placebo for febrile seizure recurrence. METHOD: Only randomized, double-blind, placebo-controlled trials were analyzed. The recurrence of febrile seizure was assessed for each drug. RESULTS: Ten eligible clinical trials were included. Febrile seizure recurrence was smaller in children treated with diazepam or phenobarbital than in placebo group. Prophylaxis with either phenobarbital or diazepam reduces recurrences of febrile seizures. The studies were clinical, methodological, and statistically heterogeneous. CONCLUSION: The effectiveness of phenobarbital and diazepam could not be demonstrated because clinical trials were heterogeneous, and the recommendation for treatment recurrence should rely upon the experience of the assistant physician yet. |
| format | Article |
| id | doaj-art-015a0c8761584da7b797e5bec08dfd02 |
| institution | DOAJ |
| issn | 0004-282X 1678-4227 |
| language | English |
| publishDate | 2003-01-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-015a0c8761584da7b797e5bec08dfd022025-08-20T03:16:35ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-42272003-01-01614897901Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysisMasuko Alice HatsueCastro Aldemar AraujoSantos Gustavo RochaAtallah Álvaro NagibPrado Lucila Bizari Fernandes doCarvalho Luciane Bizari Coin dePrado Gilmar Fernandes doConvulsions triggered by fever are the most common type of seizures in childhood, and 20% to 30% of them have recurrence. The prophylactic treatment is still controversial, so we performed a systematic review to find out the effectiveness of continuous phenobarbital and intermittent diazepam compared to placebo for febrile seizure recurrence. METHOD: Only randomized, double-blind, placebo-controlled trials were analyzed. The recurrence of febrile seizure was assessed for each drug. RESULTS: Ten eligible clinical trials were included. Febrile seizure recurrence was smaller in children treated with diazepam or phenobarbital than in placebo group. Prophylaxis with either phenobarbital or diazepam reduces recurrences of febrile seizures. The studies were clinical, methodological, and statistically heterogeneous. CONCLUSION: The effectiveness of phenobarbital and diazepam could not be demonstrated because clinical trials were heterogeneous, and the recommendation for treatment recurrence should rely upon the experience of the assistant physician yet.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000600001prophylactic treatmentfebrile seizuresintermittent diazepamcontinuous phenobarbital |
| spellingShingle | Masuko Alice Hatsue Castro Aldemar Araujo Santos Gustavo Rocha Atallah Álvaro Nagib Prado Lucila Bizari Fernandes do Carvalho Luciane Bizari Coin de Prado Gilmar Fernandes do Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis Arquivos de Neuro-Psiquiatria prophylactic treatment febrile seizures intermittent diazepam continuous phenobarbital |
| title | Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis |
| title_full | Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis |
| title_fullStr | Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis |
| title_full_unstemmed | Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis |
| title_short | Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis |
| title_sort | intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures a systematic review with meta analysis |
| topic | prophylactic treatment febrile seizures intermittent diazepam continuous phenobarbital |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2003000600001 |
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