A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques

A novel DNA and protein combination COVID-19 vaccine formulation provides full protection against SARS-CoV-2 in rhesus macaques

The current study aims to develop a safe and highly immunogenic COVID-19 vaccine. The novel combination of a DNA vaccine encoding the full-length Spike (S) protein of SARS-CoV-2 and a recombinant S1 protein vaccine induced high level neutralizing antibody and T cell immune responses in both small an...

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Bibliographic Details
Main Authors: Yuzhong Li, Yanwei Bi, Hongjian Xiao, Yueting Yao, Xiaojuan Liu, Zhengrong Hu, Jinmei Duan, Yaoyun Yang, Zhihua Li, Yadong Li, Heng Zhang, Chen Ding, Jianbo Yang, Haiwei Li, Zhanlong He, Longding Liu, Guangnan Hu, Shuying Liu, Yanchun Che, Shixia Wang, Qihan Li, Shan Lu, Wei Cun
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Emerging Microbes and Infections
Subjects:
SARS-CoV-2
spike glycoprotein
DNA vaccine
protein vaccine
non-human primate
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2021.1887767
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