Progress of deacetylase SIRTs in pathogenesis of Parkinson's disease
Sirtuins(SIRTs), a group of NAD+ dependent deacetylases, have attracted considerable attention in the field of neuro-degenerative diseases, especially Parkinson's disease (PD). They have critical impacts on cell survival and death through modulation of various biological processes, such as intr...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2024-11-01
|
| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-11-1603.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846169916625911808 |
|---|---|
| author | FANG Xue, SHI Jin, LI Haining, YANG Juan |
| author_facet | FANG Xue, SHI Jin, LI Haining, YANG Juan |
| author_sort | FANG Xue, SHI Jin, LI Haining, YANG Juan |
| collection | DOAJ |
| description | Sirtuins(SIRTs), a group of NAD+ dependent deacetylases, have attracted considerable attention in the field of neuro-degenerative diseases, especially Parkinson's disease (PD). They have critical impacts on cell survival and death through modulation of various biological processes, such as intracellular metabolism, stress response and DNA repair. In the pathogenesis of PD, Sirtuins play a crucial role and associated with pathophysiological processes such as mitochondrial function, oxidative stress, and neuronal apoptosis. Activation of Sirtuins alleviates dyskinesia and neuronal damage in animal models of PD and also regulates the aggregation and clearance of α-synuclein, a pathological feature of the disease. Therefore, the modulation of Sirtuins is a potential strategy for treating PD. |
| format | Article |
| id | doaj-art-01598e6911324bfab0b6975e9be705f9 |
| institution | Kabale University |
| issn | 1001-6325 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. |
| record_format | Article |
| series | Jichu yixue yu linchuang |
| spelling | doaj-art-01598e6911324bfab0b6975e9be705f92024-11-12T06:26:24ZzhoInstitute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.Jichu yixue yu linchuang1001-63252024-11-0144111603160710.16352/j.issn.1001-6325.2024.11.1603Progress of deacetylase SIRTs in pathogenesis of Parkinson's diseaseFANG Xue, SHI Jin, LI Haining, YANG Juan01. Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan 750004; ;2. Department of Neurology, Helan County People's Hospital, Yinchuan 750200, ChinaSirtuins(SIRTs), a group of NAD+ dependent deacetylases, have attracted considerable attention in the field of neuro-degenerative diseases, especially Parkinson's disease (PD). They have critical impacts on cell survival and death through modulation of various biological processes, such as intracellular metabolism, stress response and DNA repair. In the pathogenesis of PD, Sirtuins play a crucial role and associated with pathophysiological processes such as mitochondrial function, oxidative stress, and neuronal apoptosis. Activation of Sirtuins alleviates dyskinesia and neuronal damage in animal models of PD and also regulates the aggregation and clearance of α-synuclein, a pathological feature of the disease. Therefore, the modulation of Sirtuins is a potential strategy for treating PD.https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-11-1603.pdfparkinson's disease|deacetylase sirtuins|α-synuclein |
| spellingShingle | FANG Xue, SHI Jin, LI Haining, YANG Juan Progress of deacetylase SIRTs in pathogenesis of Parkinson's disease Jichu yixue yu linchuang parkinson's disease|deacetylase sirtuins|α-synuclein |
| title | Progress of deacetylase SIRTs in pathogenesis of Parkinson's disease |
| title_full | Progress of deacetylase SIRTs in pathogenesis of Parkinson's disease |
| title_fullStr | Progress of deacetylase SIRTs in pathogenesis of Parkinson's disease |
| title_full_unstemmed | Progress of deacetylase SIRTs in pathogenesis of Parkinson's disease |
| title_short | Progress of deacetylase SIRTs in pathogenesis of Parkinson's disease |
| title_sort | progress of deacetylase sirts in pathogenesis of parkinson s disease |
| topic | parkinson's disease|deacetylase sirtuins|α-synuclein |
| url | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2024-44-11-1603.pdf |
| work_keys_str_mv | AT fangxueshijinlihainingyangjuan progressofdeacetylasesirtsinpathogenesisofparkinsonsdisease |