Case Report: Advanced magnetic resonance imaging findings in two cases of anaplastic papillary glioneuronal tumor: one case with glioblastoma-like progression
Papillary glioneuronal tumors (PGNTs) are classified by the World Health Organization (WHO) as Grade I neoplasms, with only sporadic reports of anaplastic variants demonstrating aggressive clinical behavior and distinct histopathological characteristics. This study presents two cases of anaplastic P...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1598058/full |
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| author | Yifan Zhang Yifan Zhang Jialin He Jialin He Wei Xue Jingqin Fang Xuesong Du Xuesong Du |
| author_facet | Yifan Zhang Yifan Zhang Jialin He Jialin He Wei Xue Jingqin Fang Xuesong Du Xuesong Du |
| author_sort | Yifan Zhang |
| collection | DOAJ |
| description | Papillary glioneuronal tumors (PGNTs) are classified by the World Health Organization (WHO) as Grade I neoplasms, with only sporadic reports of anaplastic variants demonstrating aggressive clinical behavior and distinct histopathological characteristics. This study presents two cases of anaplastic PGNT, including one that ultimately progressed to glioblastoma (WHO Grade IV). The first case involved a 47-year-old female patient without a history of seizures. Magnetic resonance imaging (MRI) revealed an irregular mass containing multiple cysts and a mural nodule in the left parietal lobe. Histopathological examination confirmed the diagnosis of anaplastic PGNT. Nineteen months later, follow-up brain MRI demonstrated a recurrent mass at the prior surgical site. During the second resection, histological analysis identified glioblastoma arising from the glial component of the original tumor. The second case concerned a 7-year-old boy presenting with progressive headache. MRI showed a solid-cystic mass in the right frontal lobe accompanied by marked peritumoral edema. Postoperative pathological examination revealed anaplastic PGNT with extensive necrosis. MRI characteristics including prominent peritumoral edema, ring-enhancing cyst walls, restricted diffusion, and elevated lipid/lactate peaks may predict the aggressive nature of anaplastic PGNT. Furthermore, this case series suggests that anaplastic PGNTs harbor malignant potential to transform into more aggressive neoplasms. |
| format | Article |
| id | doaj-art-01551a2c92dc42969ae3a231e76381d2 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-01551a2c92dc42969ae3a231e76381d22025-08-20T03:36:01ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-08-011510.3389/fonc.2025.15980581598058Case Report: Advanced magnetic resonance imaging findings in two cases of anaplastic papillary glioneuronal tumor: one case with glioblastoma-like progressionYifan Zhang0Yifan Zhang1Jialin He2Jialin He3Wei Xue4Jingqin Fang5Xuesong Du6Xuesong Du7Department of Radiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaDepartment of Stomatology, The 940th Hospital of Joint Logistic Support Force of Chinese Peoples Liberation Army, Lanzhou, ChinaMedical Imaging Research Center, Anhui Medical University, Hefei, ChinaSchool of Modern Health and Regimen Industry, Anhui Sanlian University, Hefei, ChinaDepartment of Radiology, The 940th Hospital of Joint Logistic Support Force of Chinese Peoples Liberation Army, Lanzhou, ChinaDepartment of Ultrasound, Daping Hospital, Army Medical University, Chongqing, ChinaDepartment of Radiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, ChinaMedical Imaging Research Center, Anhui Medical University, Hefei, ChinaPapillary glioneuronal tumors (PGNTs) are classified by the World Health Organization (WHO) as Grade I neoplasms, with only sporadic reports of anaplastic variants demonstrating aggressive clinical behavior and distinct histopathological characteristics. This study presents two cases of anaplastic PGNT, including one that ultimately progressed to glioblastoma (WHO Grade IV). The first case involved a 47-year-old female patient without a history of seizures. Magnetic resonance imaging (MRI) revealed an irregular mass containing multiple cysts and a mural nodule in the left parietal lobe. Histopathological examination confirmed the diagnosis of anaplastic PGNT. Nineteen months later, follow-up brain MRI demonstrated a recurrent mass at the prior surgical site. During the second resection, histological analysis identified glioblastoma arising from the glial component of the original tumor. The second case concerned a 7-year-old boy presenting with progressive headache. MRI showed a solid-cystic mass in the right frontal lobe accompanied by marked peritumoral edema. Postoperative pathological examination revealed anaplastic PGNT with extensive necrosis. MRI characteristics including prominent peritumoral edema, ring-enhancing cyst walls, restricted diffusion, and elevated lipid/lactate peaks may predict the aggressive nature of anaplastic PGNT. Furthermore, this case series suggests that anaplastic PGNTs harbor malignant potential to transform into more aggressive neoplasms.https://www.frontiersin.org/articles/10.3389/fonc.2025.1598058/fullpapillary glioneuronal tumoranaplasticadvanced MRIrecurrentmalignant transformation |
| spellingShingle | Yifan Zhang Yifan Zhang Jialin He Jialin He Wei Xue Jingqin Fang Xuesong Du Xuesong Du Case Report: Advanced magnetic resonance imaging findings in two cases of anaplastic papillary glioneuronal tumor: one case with glioblastoma-like progression Frontiers in Oncology papillary glioneuronal tumor anaplastic advanced MRI recurrent malignant transformation |
| title | Case Report: Advanced magnetic resonance imaging findings in two cases of anaplastic papillary glioneuronal tumor: one case with glioblastoma-like progression |
| title_full | Case Report: Advanced magnetic resonance imaging findings in two cases of anaplastic papillary glioneuronal tumor: one case with glioblastoma-like progression |
| title_fullStr | Case Report: Advanced magnetic resonance imaging findings in two cases of anaplastic papillary glioneuronal tumor: one case with glioblastoma-like progression |
| title_full_unstemmed | Case Report: Advanced magnetic resonance imaging findings in two cases of anaplastic papillary glioneuronal tumor: one case with glioblastoma-like progression |
| title_short | Case Report: Advanced magnetic resonance imaging findings in two cases of anaplastic papillary glioneuronal tumor: one case with glioblastoma-like progression |
| title_sort | case report advanced magnetic resonance imaging findings in two cases of anaplastic papillary glioneuronal tumor one case with glioblastoma like progression |
| topic | papillary glioneuronal tumor anaplastic advanced MRI recurrent malignant transformation |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1598058/full |
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