A Rare Case of Lichen Planus/Discoid Lupus Erythematosus Overlap Syndrome and Its Successful Treatment
ABSTRACT An uncommon condition referred to as the overlap syndrome of lichen planus (LP) and lupus erythematosus (LE) exhibits immunopathological, histological, and clinical characteristics of both LP and LE. Though LP and LE are common individually, their overlap is rare. This condition typically p...
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| Language: | English |
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Wiley
2025-08-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.70704 |
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| author | Shehdev Meghwar Muskan Batra Noor Zehra Shabbir Preety Devi Ajeet Singh Asma Ikram Amogh Verma |
| author_facet | Shehdev Meghwar Muskan Batra Noor Zehra Shabbir Preety Devi Ajeet Singh Asma Ikram Amogh Verma |
| author_sort | Shehdev Meghwar |
| collection | DOAJ |
| description | ABSTRACT An uncommon condition referred to as the overlap syndrome of lichen planus (LP) and lupus erythematosus (LE) exhibits immunopathological, histological, and clinical characteristics of both LP and LE. Though LP and LE are common individually, their overlap is rare. This condition typically presents with large, scaly, centrally atrophic lesions on the distal limbs, face, and trunk, often bluish‐red to hypopigmented in color. We describe a unique case of overlap syndrome between LP and discoid LE in a 30‐year‐old female patient presenting with lesions on her scalp, limbs, the dorsum of her hands, and oral mucosa. The lesions were neither painful nor warm to the touch. The diagnosis of overlap syndrome involving discoid LE and LP was confirmed through laboratory investigations and dermatological evaluation. Initial treatment with clobetasol propionate showed no significant improvement. Subsequently, the patient was prescribed 200 mg of azathioprine daily, along with the corticosteroid Deflazacort. Notable improvement in the lesions was observed after 4–5 weeks of follow‐up. |
| format | Article |
| id | doaj-art-0150bb7ded884e90b477acff974ea36a |
| institution | Kabale University |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-0150bb7ded884e90b477acff974ea36a2025-08-22T07:33:07ZengWileyClinical Case Reports2050-09042025-08-01138n/an/a10.1002/ccr3.70704A Rare Case of Lichen Planus/Discoid Lupus Erythematosus Overlap Syndrome and Its Successful TreatmentShehdev Meghwar0Muskan Batra1Noor Zehra Shabbir2Preety Devi3Ajeet Singh4Asma Ikram5Amogh Verma6Liaquat University of Medical and Health Sciences Jamshoro PakistanLiaquat University of Medical and Health Sciences Jamshoro PakistanKarachi Medical and Dental College Karachi PakistanLiaquat University of Medical and Health Sciences Jamshoro PakistanDow University of Health Sciences Karachi PakistanDepartment of Dermatology Liaquat University of Medical and Health Sciences Jamshoro PakistanSR Sanjeevani Hospital Siraha NepalABSTRACT An uncommon condition referred to as the overlap syndrome of lichen planus (LP) and lupus erythematosus (LE) exhibits immunopathological, histological, and clinical characteristics of both LP and LE. Though LP and LE are common individually, their overlap is rare. This condition typically presents with large, scaly, centrally atrophic lesions on the distal limbs, face, and trunk, often bluish‐red to hypopigmented in color. We describe a unique case of overlap syndrome between LP and discoid LE in a 30‐year‐old female patient presenting with lesions on her scalp, limbs, the dorsum of her hands, and oral mucosa. The lesions were neither painful nor warm to the touch. The diagnosis of overlap syndrome involving discoid LE and LP was confirmed through laboratory investigations and dermatological evaluation. Initial treatment with clobetasol propionate showed no significant improvement. Subsequently, the patient was prescribed 200 mg of azathioprine daily, along with the corticosteroid Deflazacort. Notable improvement in the lesions was observed after 4–5 weeks of follow‐up.https://doi.org/10.1002/ccr3.70704case reportlichen planuslupus erythematosuslupus erythematosus/lichen planus overlap syndromeoverlap |
| spellingShingle | Shehdev Meghwar Muskan Batra Noor Zehra Shabbir Preety Devi Ajeet Singh Asma Ikram Amogh Verma A Rare Case of Lichen Planus/Discoid Lupus Erythematosus Overlap Syndrome and Its Successful Treatment Clinical Case Reports case report lichen planus lupus erythematosus lupus erythematosus/lichen planus overlap syndrome overlap |
| title | A Rare Case of Lichen Planus/Discoid Lupus Erythematosus Overlap Syndrome and Its Successful Treatment |
| title_full | A Rare Case of Lichen Planus/Discoid Lupus Erythematosus Overlap Syndrome and Its Successful Treatment |
| title_fullStr | A Rare Case of Lichen Planus/Discoid Lupus Erythematosus Overlap Syndrome and Its Successful Treatment |
| title_full_unstemmed | A Rare Case of Lichen Planus/Discoid Lupus Erythematosus Overlap Syndrome and Its Successful Treatment |
| title_short | A Rare Case of Lichen Planus/Discoid Lupus Erythematosus Overlap Syndrome and Its Successful Treatment |
| title_sort | rare case of lichen planus discoid lupus erythematosus overlap syndrome and its successful treatment |
| topic | case report lichen planus lupus erythematosus lupus erythematosus/lichen planus overlap syndrome overlap |
| url | https://doi.org/10.1002/ccr3.70704 |
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