Increased accuracy of single photon emission computed tomography (SPECT) myocardial perfusion scintigraphy using iterative reconstruction of images
Background/Aim. Filtered back projection (FBP) is a common way of processing myocardial perfusion imaging (MPI) studies. There are artifacts in FBP which can cause falsepositive results. Iterative reconstruction (IR) is developed to reduce false positive findings in MPI studies. The aim of...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2016-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2016/0042-84501600035S.pdf |
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| Summary: | Background/Aim. Filtered back projection (FBP) is a common way of processing
myocardial perfusion imaging (MPI) studies. There are artifacts in FBP which
can cause falsepositive results. Iterative reconstruction (IR) is developed
to reduce false positive findings in MPI studies. The aim of this study was
to evaluate the difference in the number of false positive findings in MPI
studies, between FBP and IR processing. Methods. We examined 107 patients
with angina pectoris with MPI and coronary angiography (CAG), 77 man and 30
woman, aged 32−82. MPI studies were processed with FBP and with IR. Positive
finding at MPI was visualization of the perfusion defect. Positive finding at
CAG was stenosis of coronary artery. Perfusion defect at MPI without coronary
artery stenosis at CAG was considered like false positive. The results were
statistically analyzed with bivariate correlation, and with one sample
t-test. Results. There were 20.6% normal, and 79.4% pathologic findings at
FBP, 30.8% normal and 69.2% pathologic with IR and 37.4% normal and 62.6%
pathologic at CAG. FBP produced 19 false-positive findings, at IR 11 false
positive findings. The correlation between FBP and CAG was 0.658 (p < 0.01)
and between IR and CAG 0.784 (p < 0.01). The number of false positive
findings at MPI with IR was significantly lower than at FBP (p < 0.01).
Conclusion. Our study shows that IR processing MPI scintigraphy has less
number of false positive findings, therefore it is our choice for processing
MPI studies. |
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| ISSN: | 0042-8450 2406-0720 |