Predictive Value of Cardiopulmonary Exercise Testing Parameters in Patients under Percutaneous Coronary Intervention with High Pulse Pressure
Background: The correlation between cardiopulmonary exercise testing (CPET) parameters and the prognosis of patients undergoing percutaneous coronary intervention (PCI) with high pulse pressure (PP) is unclear. The purpose of present study is to investigate the correlation of CPET...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2025-02-01
|
| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/RCM/26/2/10.31083/RCM25847 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850043975087423488 |
|---|---|
| author | Qiang Ren Xingbo Mu Yushan Li Jian Zhang Yanchun Liang Quanyu Zhang Yaling Han |
| author_facet | Qiang Ren Xingbo Mu Yushan Li Jian Zhang Yanchun Liang Quanyu Zhang Yaling Han |
| author_sort | Qiang Ren |
| collection | DOAJ |
| description | Background: The correlation between cardiopulmonary exercise testing (CPET) parameters and the prognosis of patients undergoing percutaneous coronary intervention (PCI) with high pulse pressure (PP) is unclear. The purpose of present study is to investigate the correlation of CPET parameters in patients under PCI with high PP and assess their reference value for prognosis. Methods: Individuals aged 18 years and older who were diagnosed with coronary artery disease (CAD) and underwent PCI along with CPET from November 1, 2015 to September 30, 2021 were enrolled. The patients were categorized into two groups based on PP: high PP group (PP of males ≥50 mmHg; PP of females ≥60 mmHg) and normal PP group (PP of males <50 mmHg; PP of females <60 mmHg). The primary endpoint was major adverse cardiovascular events (MACE). The optimal predictors of MACE were identified through Cox regression analysis. The time-dependent receiver operating characteristic (ROC) curves were generated and the area under the ROC curve (AUC) was measured to evaluate the discriminatory ability in patients with high PP. Results: A total of 2785 patients were included in present study, with a median follow-up period of 1215 (687–1586) days. Through multifactorial analysis, it was determined that peak oxygen uptake (peak VO2, hazard ratio (HR): 0.94, 95% confidence interval (95% CI): 0.88 to 1.00, p = 0.038) and ventilatory equivalent for carbon dioxide (VE/VCO2, HR: 1.08, 95% CI: 1.02 to 1.15, p = 0.007) are important predictive factors in the parameters of CPET. The ROC based on diabetes mellitus (DM), smoking, peak VO2, and VE/VCO2 could effectively evaluate the prognosis of patients [1-year AUC: 0.636 (0.515~0.758), 3-year AUC: 0.675 (0.599~0.752), 5-year AUC: 0.718 (0.607~0.830)]. Conclusions: The prognosis of CAD patients with high PP was worse compared to the patients with normal PP. The peak VO2 and VE/VCO2 were predictors of MACE in CAD patients with high PP. |
| format | Article |
| id | doaj-art-014ee16ca9a2425abb0c57b2d7dfe32e |
| institution | DOAJ |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-014ee16ca9a2425abb0c57b2d7dfe32e2025-08-20T02:55:06ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-02-012622584710.31083/RCM25847S1530-6550(24)01665-XPredictive Value of Cardiopulmonary Exercise Testing Parameters in Patients under Percutaneous Coronary Intervention with High Pulse PressureQiang Ren0Xingbo Mu1Yushan Li2Jian Zhang3Yanchun Liang4Quanyu Zhang5Yaling Han6State Key Laboratory of Frigid Zone Cardiovascular Diseases, Department of Cardiology, General Hospital of Northern Theater Command, 110016 Shenyang, Liaoning, ChinaState Key Laboratory of Frigid Zone Cardiovascular Diseases, Department of Cardiology, General Hospital of Northern Theater Command, 110016 Shenyang, Liaoning, ChinaState Key Laboratory of Frigid Zone Cardiovascular Diseases, Department of Cardiology, General Hospital of Northern Theater Command, 110016 Shenyang, Liaoning, ChinaState Key Laboratory of Frigid Zone Cardiovascular Diseases, Department of Cardiology, General Hospital of Northern Theater Command, 110016 Shenyang, Liaoning, ChinaState Key Laboratory of Frigid Zone Cardiovascular Diseases, Department of Cardiology, General Hospital of Northern Theater Command, 110016 Shenyang, Liaoning, ChinaState Key Laboratory of Frigid Zone Cardiovascular Diseases, Department of Cardiology, General Hospital of Northern Theater Command, 110016 Shenyang, Liaoning, ChinaState Key Laboratory of Frigid Zone Cardiovascular Diseases, Department of Cardiology, General Hospital of Northern Theater Command, 110016 Shenyang, Liaoning, ChinaBackground: The correlation between cardiopulmonary exercise testing (CPET) parameters and the prognosis of patients undergoing percutaneous coronary intervention (PCI) with high pulse pressure (PP) is unclear. The purpose of present study is to investigate the correlation of CPET parameters in patients under PCI with high PP and assess their reference value for prognosis. Methods: Individuals aged 18 years and older who were diagnosed with coronary artery disease (CAD) and underwent PCI along with CPET from November 1, 2015 to September 30, 2021 were enrolled. The patients were categorized into two groups based on PP: high PP group (PP of males ≥50 mmHg; PP of females ≥60 mmHg) and normal PP group (PP of males <50 mmHg; PP of females <60 mmHg). The primary endpoint was major adverse cardiovascular events (MACE). The optimal predictors of MACE were identified through Cox regression analysis. The time-dependent receiver operating characteristic (ROC) curves were generated and the area under the ROC curve (AUC) was measured to evaluate the discriminatory ability in patients with high PP. Results: A total of 2785 patients were included in present study, with a median follow-up period of 1215 (687–1586) days. Through multifactorial analysis, it was determined that peak oxygen uptake (peak VO2, hazard ratio (HR): 0.94, 95% confidence interval (95% CI): 0.88 to 1.00, p = 0.038) and ventilatory equivalent for carbon dioxide (VE/VCO2, HR: 1.08, 95% CI: 1.02 to 1.15, p = 0.007) are important predictive factors in the parameters of CPET. The ROC based on diabetes mellitus (DM), smoking, peak VO2, and VE/VCO2 could effectively evaluate the prognosis of patients [1-year AUC: 0.636 (0.515~0.758), 3-year AUC: 0.675 (0.599~0.752), 5-year AUC: 0.718 (0.607~0.830)]. Conclusions: The prognosis of CAD patients with high PP was worse compared to the patients with normal PP. The peak VO2 and VE/VCO2 were predictors of MACE in CAD patients with high PP.https://www.imrpress.com/journal/RCM/26/2/10.31083/RCM25847coronary artery diseasecardiopulmonary exercise testinghigh pulse pressuremajor adverse cardiovascular events |
| spellingShingle | Qiang Ren Xingbo Mu Yushan Li Jian Zhang Yanchun Liang Quanyu Zhang Yaling Han Predictive Value of Cardiopulmonary Exercise Testing Parameters in Patients under Percutaneous Coronary Intervention with High Pulse Pressure Reviews in Cardiovascular Medicine coronary artery disease cardiopulmonary exercise testing high pulse pressure major adverse cardiovascular events |
| title | Predictive Value of Cardiopulmonary Exercise Testing Parameters in Patients under Percutaneous Coronary Intervention with High Pulse Pressure |
| title_full | Predictive Value of Cardiopulmonary Exercise Testing Parameters in Patients under Percutaneous Coronary Intervention with High Pulse Pressure |
| title_fullStr | Predictive Value of Cardiopulmonary Exercise Testing Parameters in Patients under Percutaneous Coronary Intervention with High Pulse Pressure |
| title_full_unstemmed | Predictive Value of Cardiopulmonary Exercise Testing Parameters in Patients under Percutaneous Coronary Intervention with High Pulse Pressure |
| title_short | Predictive Value of Cardiopulmonary Exercise Testing Parameters in Patients under Percutaneous Coronary Intervention with High Pulse Pressure |
| title_sort | predictive value of cardiopulmonary exercise testing parameters in patients under percutaneous coronary intervention with high pulse pressure |
| topic | coronary artery disease cardiopulmonary exercise testing high pulse pressure major adverse cardiovascular events |
| url | https://www.imrpress.com/journal/RCM/26/2/10.31083/RCM25847 |
| work_keys_str_mv | AT qiangren predictivevalueofcardiopulmonaryexercisetestingparametersinpatientsunderpercutaneouscoronaryinterventionwithhighpulsepressure AT xingbomu predictivevalueofcardiopulmonaryexercisetestingparametersinpatientsunderpercutaneouscoronaryinterventionwithhighpulsepressure AT yushanli predictivevalueofcardiopulmonaryexercisetestingparametersinpatientsunderpercutaneouscoronaryinterventionwithhighpulsepressure AT jianzhang predictivevalueofcardiopulmonaryexercisetestingparametersinpatientsunderpercutaneouscoronaryinterventionwithhighpulsepressure AT yanchunliang predictivevalueofcardiopulmonaryexercisetestingparametersinpatientsunderpercutaneouscoronaryinterventionwithhighpulsepressure AT quanyuzhang predictivevalueofcardiopulmonaryexercisetestingparametersinpatientsunderpercutaneouscoronaryinterventionwithhighpulsepressure AT yalinghan predictivevalueofcardiopulmonaryexercisetestingparametersinpatientsunderpercutaneouscoronaryinterventionwithhighpulsepressure |