Comparative clinical and economic evaluation of polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in the 1<sup>st</sup> line therapy for adult patients with diffuse large B-cell lymphoma
Aim. To assess the pharmacoeconomic feasibility of using polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in 1st line therapy of adult patients with diffuse large B-cell lymphoma in the Russian healthcare system, taking into account the curren...
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ABV-press
2023-03-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/801 |
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| author | I. N. Dyakov |
| author_facet | I. N. Dyakov |
| author_sort | I. N. Dyakov |
| collection | DOAJ |
| description | Aim. To assess the pharmacoeconomic feasibility of using polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in 1st line therapy of adult patients with diffuse large B-cell lymphoma in the Russian healthcare system, taking into account the currently used therapeutic practices in oncohematology.Materials and methods. The design of the study is a retrospective analysis of literature data. Clinical and economic analysis (incremental cost–effectiveness analysis, case-based approach) was performed using sensitivity assessment. The sources of data on the effectiveness of the analyzed drugs were publications on clinical trials, on the cost of drugs – the state register of maximum selling prices, data from the manufacturer.Results. An incremental cost–effectiveness analysis was performed using a case-based approach comparing the cost of progression-free life-year gained. Brentuximab vedotin, already included in the list of vital and essential drugs and provided at the expense of budgetary funds, was chosen as the reference drug. It has been established that the cost of progression-free life-year gained (ICER) with the use of polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in 1st line therapy of adult patients with diffuse large B-cell lymphoma by 60.8 %, or 41.6 million rubles, lower than the cost of progression-free life-year gained when using brentuximab vedotin in combination with doxorubicin, vinblastine and dacarbazine in the 1st line therapy of patients with CD30-positive classical Hodgkin’s lymphoma. Sensitivity assessment showed the stability of the obtained results of clinical and economic analysis to changes in the cost of drugs in compared therapy regimens. The results were sensitive to changes in the efficacy of the compared regimens.Conclusion. The obtained results of the clinical and economic analysis demonstrated that the use of polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in the 1st line therapy of adult patients with diffuse large B-cell lymphoma in the Russian healthcare system is economically appropriate. |
| format | Article |
| id | doaj-art-014ebf8a7ef147fb97fb0acd057b957f |
| institution | DOAJ |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2023-03-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-014ebf8a7ef147fb97fb0acd057b957f2025-08-20T03:01:02ZrusABV-pressОнкогематология1818-83462413-40232023-03-01181768710.17650/1818-8346-2023-18-1-76-87673Comparative clinical and economic evaluation of polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in the 1<sup>st</sup> line therapy for adult patients with diffuse large B-cell lymphomaI. N. Dyakov0Scientific and Practical Center for Rational Pharmacotherapy and Pharmacoeconomics Problems; I.I. Mechnikov Research Institute of Vaccines and SerumsAim. To assess the pharmacoeconomic feasibility of using polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in 1st line therapy of adult patients with diffuse large B-cell lymphoma in the Russian healthcare system, taking into account the currently used therapeutic practices in oncohematology.Materials and methods. The design of the study is a retrospective analysis of literature data. Clinical and economic analysis (incremental cost–effectiveness analysis, case-based approach) was performed using sensitivity assessment. The sources of data on the effectiveness of the analyzed drugs were publications on clinical trials, on the cost of drugs – the state register of maximum selling prices, data from the manufacturer.Results. An incremental cost–effectiveness analysis was performed using a case-based approach comparing the cost of progression-free life-year gained. Brentuximab vedotin, already included in the list of vital and essential drugs and provided at the expense of budgetary funds, was chosen as the reference drug. It has been established that the cost of progression-free life-year gained (ICER) with the use of polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in 1st line therapy of adult patients with diffuse large B-cell lymphoma by 60.8 %, or 41.6 million rubles, lower than the cost of progression-free life-year gained when using brentuximab vedotin in combination with doxorubicin, vinblastine and dacarbazine in the 1st line therapy of patients with CD30-positive classical Hodgkin’s lymphoma. Sensitivity assessment showed the stability of the obtained results of clinical and economic analysis to changes in the cost of drugs in compared therapy regimens. The results were sensitive to changes in the efficacy of the compared regimens.Conclusion. The obtained results of the clinical and economic analysis demonstrated that the use of polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in the 1st line therapy of adult patients with diffuse large B-cell lymphoma in the Russian healthcare system is economically appropriate.https://oncohematology.abvpress.ru/ongm/article/view/801polatuzumab vedotindiffuse large b-cell lymphomacase-based approachclinical and economic analysisfirst-line therapycost of progression-free life-year |
| spellingShingle | I. N. Dyakov Comparative clinical and economic evaluation of polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in the 1<sup>st</sup> line therapy for adult patients with diffuse large B-cell lymphoma Онкогематология polatuzumab vedotin diffuse large b-cell lymphoma case-based approach clinical and economic analysis first-line therapy cost of progression-free life-year |
| title | Comparative clinical and economic evaluation of polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in the 1<sup>st</sup> line therapy for adult patients with diffuse large B-cell lymphoma |
| title_full | Comparative clinical and economic evaluation of polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in the 1<sup>st</sup> line therapy for adult patients with diffuse large B-cell lymphoma |
| title_fullStr | Comparative clinical and economic evaluation of polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in the 1<sup>st</sup> line therapy for adult patients with diffuse large B-cell lymphoma |
| title_full_unstemmed | Comparative clinical and economic evaluation of polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in the 1<sup>st</sup> line therapy for adult patients with diffuse large B-cell lymphoma |
| title_short | Comparative clinical and economic evaluation of polatuzumab vedotin in combination with rituximab, cyclophosphamide, doxorubicin and prednisolone (R-CHP) in the 1<sup>st</sup> line therapy for adult patients with diffuse large B-cell lymphoma |
| title_sort | comparative clinical and economic evaluation of polatuzumab vedotin in combination with rituximab cyclophosphamide doxorubicin and prednisolone r chp in the 1 sup st sup line therapy for adult patients with diffuse large b cell lymphoma |
| topic | polatuzumab vedotin diffuse large b-cell lymphoma case-based approach clinical and economic analysis first-line therapy cost of progression-free life-year |
| url | https://oncohematology.abvpress.ru/ongm/article/view/801 |
| work_keys_str_mv | AT indyakov comparativeclinicalandeconomicevaluationofpolatuzumabvedotinincombinationwithrituximabcyclophosphamidedoxorubicinandprednisolonerchpinthe1supstsuplinetherapyforadultpatientswithdiffuselargebcelllymphoma |