Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia
Introduction Human immunodeficiency virus (HIV) is characterized by a progressive damage of immune system, resulting in a number of opportunistic infections and hematological abnormalities, and become more severe in late stages. Hematological abnormalities are common manifestations, with factors inc...
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Termedia Publishing House
2024-09-01
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| Series: | HIV & AIDS Review. International Journal of HIV-Related Problems |
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| Online Access: | https://hivaids.termedia.pl/Factors-affecting-hematological-abnormality-in-HIV-infected-patients-at-Dr-Wahidin,156690,0,2.html |
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| author | I. Nyoman Yogi Wiraguna Andi Fachruddin Benyamin Risna Halim Syakib Bakri Sahyuddin Saleh Hasyim Kasim Andi Alfian Zainuddin |
| author_facet | I. Nyoman Yogi Wiraguna Andi Fachruddin Benyamin Risna Halim Syakib Bakri Sahyuddin Saleh Hasyim Kasim Andi Alfian Zainuddin |
| author_sort | I. Nyoman Yogi Wiraguna |
| collection | DOAJ |
| description | Introduction
Human immunodeficiency virus (HIV) is characterized by a progressive damage of immune system, resulting in a number of opportunistic infections and hematological abnormalities, and become more severe in late stages. Hematological abnormalities are common manifestations, with factors including CD4+ count, opportunistic infection, and HIV viral load. The aim of this study was to investigate the correlation between CD4+ count, opportunistic infection, and HIV viral load with hematological abnormality in HIV patients.
Material and methods
An observational study was conducted at tertiary institution, Dr. Wahidin Sudirohusodo Hospital, Makassar, from November 2021 to February 2022. Secondary data from medical records of HIV-infected patients were used. Chi-square test and independent t-test were employed to determine the correlation between CD4+ count, opportunistic infection, and HIV viral load with hematological abnormality.
Results
Among 83 HIV subjects, anemia was present in 47% of the cases. Leucopenia, lymphopenia, and thrombocytopenia were observed in 10.8%, 28.9%, and 9.6%, respectively. Anemia and lymphopenia significantly correlated with CD4+ count (p 0.05), between anemia and lymphopenia with opportunistic infection and co-infection (p > 0.05), and between anemia, leucopenia, lymphopenia, and thrombocytopenia with viral load (p > 0.05).
Conclusions
Anemia and lymphopenia significantly correlated with CD4+ count. CD4+ count monitoring is needed for early detection of hematological abnormalities in order to lower morbidity and increase quality of life. |
| format | Article |
| id | doaj-art-014c9bcfb06443e5a416f0f6e6ab7337 |
| institution | Kabale University |
| issn | 1730-1270 1732-2707 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | HIV & AIDS Review. International Journal of HIV-Related Problems |
| spelling | doaj-art-014c9bcfb06443e5a416f0f6e6ab73372025-01-27T11:05:56ZengTermedia Publishing HouseHIV & AIDS Review. International Journal of HIV-Related Problems1730-12701732-27072024-09-0123321722510.5114/hivar/156690156690Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, IndonesiaI. Nyoman Yogi Wiraguna0https://orcid.org/0000-0002-3488-2596Andi Fachruddin Benyamin1https://orcid.org/0000-0003-1811-0497Risna Halim2https://orcid.org/0000-0002-3847-8849Syakib Bakri3https://orcid.org/0000-0002-6615-5166Sahyuddin Saleh4https://orcid.org/0000-0002-6640-6762Hasyim Kasim5https://orcid.org/0000-0002-3261-2859Andi Alfian Zainuddin6https://orcid.org/0000-0003-4436-3906Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaDepartment of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, IndonesiaPublic Health and Community Medicine Department, Hasanuddin University, Makassar, IndonesiaIntroduction Human immunodeficiency virus (HIV) is characterized by a progressive damage of immune system, resulting in a number of opportunistic infections and hematological abnormalities, and become more severe in late stages. Hematological abnormalities are common manifestations, with factors including CD4+ count, opportunistic infection, and HIV viral load. The aim of this study was to investigate the correlation between CD4+ count, opportunistic infection, and HIV viral load with hematological abnormality in HIV patients. Material and methods An observational study was conducted at tertiary institution, Dr. Wahidin Sudirohusodo Hospital, Makassar, from November 2021 to February 2022. Secondary data from medical records of HIV-infected patients were used. Chi-square test and independent t-test were employed to determine the correlation between CD4+ count, opportunistic infection, and HIV viral load with hematological abnormality. Results Among 83 HIV subjects, anemia was present in 47% of the cases. Leucopenia, lymphopenia, and thrombocytopenia were observed in 10.8%, 28.9%, and 9.6%, respectively. Anemia and lymphopenia significantly correlated with CD4+ count (p 0.05), between anemia and lymphopenia with opportunistic infection and co-infection (p > 0.05), and between anemia, leucopenia, lymphopenia, and thrombocytopenia with viral load (p > 0.05). Conclusions Anemia and lymphopenia significantly correlated with CD4+ count. CD4+ count monitoring is needed for early detection of hematological abnormalities in order to lower morbidity and increase quality of life.https://hivaids.termedia.pl/Factors-affecting-hematological-abnormality-in-HIV-infected-patients-at-Dr-Wahidin,156690,0,2.htmlhiv infectionhematological abnormalitycd4+ countopportunistic infectionviral load. |
| spellingShingle | I. Nyoman Yogi Wiraguna Andi Fachruddin Benyamin Risna Halim Syakib Bakri Sahyuddin Saleh Hasyim Kasim Andi Alfian Zainuddin Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia HIV & AIDS Review. International Journal of HIV-Related Problems hiv infection hematological abnormality cd4+ count opportunistic infection viral load. |
| title | Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia |
| title_full | Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia |
| title_fullStr | Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia |
| title_full_unstemmed | Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia |
| title_short | Factors affecting hematological abnormality in HIV-infected patients at Dr. Wahidin Sudirohusodo Hospital Makassar, Indonesia |
| title_sort | factors affecting hematological abnormality in hiv infected patients at dr wahidin sudirohusodo hospital makassar indonesia |
| topic | hiv infection hematological abnormality cd4+ count opportunistic infection viral load. |
| url | https://hivaids.termedia.pl/Factors-affecting-hematological-abnormality-in-HIV-infected-patients-at-Dr-Wahidin,156690,0,2.html |
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