Extracellular RNA in oncogenesis, metastasis and drug resistance
Extracellular vesicles and nanoparticles (EVPs) are now recognized as a novel form of cell–cell communication. All cells release a wide array of heterogeneous EVPs with distinct protein, lipid, and RNA content, dependent on the pathophysiological state of the donor cell. The overall cargo content in...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | RNA Biology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15476286.2024.2385607 |
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| author | Hannah Nelson Sherman Qu Jeffrey L. Franklin Qi Liu Heather H. Pua Kasey C. Vickers Alissa M. Weaver Robert J. Coffey James G. Patton |
| author_facet | Hannah Nelson Sherman Qu Jeffrey L. Franklin Qi Liu Heather H. Pua Kasey C. Vickers Alissa M. Weaver Robert J. Coffey James G. Patton |
| author_sort | Hannah Nelson |
| collection | DOAJ |
| description | Extracellular vesicles and nanoparticles (EVPs) are now recognized as a novel form of cell–cell communication. All cells release a wide array of heterogeneous EVPs with distinct protein, lipid, and RNA content, dependent on the pathophysiological state of the donor cell. The overall cargo content in EVPs is not equivalent to cellular levels, implying a regulated pathway for selection and export. In cancer, release and uptake of EVPs within the tumour microenvironment can influence growth, proliferation, invasiveness, and immune evasion. Secreted EVPs can also have distant, systemic effects that can promote metastasis. Here, we review current knowledge of EVP biogenesis and cargo selection with a focus on the role that extracellular RNA plays in oncogenesis and metastasis. Almost all subtypes of RNA have been identified in EVPs, with miRNAs being the best characterized. We review the roles of specific miRNAs that have been detected in EVPs and that play a role in oncogenesis and metastasis. |
| format | Article |
| id | doaj-art-0149ce03e8b64eb8b051c0b241d31077 |
| institution | OA Journals |
| issn | 1547-6286 1555-8584 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | RNA Biology |
| spelling | doaj-art-0149ce03e8b64eb8b051c0b241d310772025-08-20T02:39:08ZengTaylor & Francis GroupRNA Biology1547-62861555-85842024-12-0121180581910.1080/15476286.2024.2385607Extracellular RNA in oncogenesis, metastasis and drug resistanceHannah Nelson0Sherman Qu1Jeffrey L. Franklin2Qi Liu3Heather H. Pua4Kasey C. Vickers5Alissa M. Weaver6Robert J. Coffey7James G. Patton8Department of Biological Sciences, Vanderbilt University and Vanderbilt University Medical Center, Nashville, TN, USADepartment of Biological Sciences, Vanderbilt University and Vanderbilt University Medical Center, Nashville, TN, USACenter for Extracellular Vesicle Research, Vanderbilt University School of Medicine, Nashville, TN, USACenter for Extracellular Vesicle Research, Vanderbilt University School of Medicine, Nashville, TN, USACenter for Extracellular Vesicle Research, Vanderbilt University School of Medicine, Nashville, TN, USACenter for Extracellular Vesicle Research, Vanderbilt University School of Medicine, Nashville, TN, USACenter for Extracellular Vesicle Research, Vanderbilt University School of Medicine, Nashville, TN, USACenter for Extracellular Vesicle Research, Vanderbilt University School of Medicine, Nashville, TN, USADepartment of Biological Sciences, Vanderbilt University and Vanderbilt University Medical Center, Nashville, TN, USAExtracellular vesicles and nanoparticles (EVPs) are now recognized as a novel form of cell–cell communication. All cells release a wide array of heterogeneous EVPs with distinct protein, lipid, and RNA content, dependent on the pathophysiological state of the donor cell. The overall cargo content in EVPs is not equivalent to cellular levels, implying a regulated pathway for selection and export. In cancer, release and uptake of EVPs within the tumour microenvironment can influence growth, proliferation, invasiveness, and immune evasion. Secreted EVPs can also have distant, systemic effects that can promote metastasis. Here, we review current knowledge of EVP biogenesis and cargo selection with a focus on the role that extracellular RNA plays in oncogenesis and metastasis. Almost all subtypes of RNA have been identified in EVPs, with miRNAs being the best characterized. We review the roles of specific miRNAs that have been detected in EVPs and that play a role in oncogenesis and metastasis.https://www.tandfonline.com/doi/10.1080/15476286.2024.2385607extracellular vesiclesnanoparticlesRNACancerTumor microenviromentmetastasis |
| spellingShingle | Hannah Nelson Sherman Qu Jeffrey L. Franklin Qi Liu Heather H. Pua Kasey C. Vickers Alissa M. Weaver Robert J. Coffey James G. Patton Extracellular RNA in oncogenesis, metastasis and drug resistance RNA Biology extracellular vesicles nanoparticles RNA Cancer Tumor microenviroment metastasis |
| title | Extracellular RNA in oncogenesis, metastasis and drug resistance |
| title_full | Extracellular RNA in oncogenesis, metastasis and drug resistance |
| title_fullStr | Extracellular RNA in oncogenesis, metastasis and drug resistance |
| title_full_unstemmed | Extracellular RNA in oncogenesis, metastasis and drug resistance |
| title_short | Extracellular RNA in oncogenesis, metastasis and drug resistance |
| title_sort | extracellular rna in oncogenesis metastasis and drug resistance |
| topic | extracellular vesicles nanoparticles RNA Cancer Tumor microenviroment metastasis |
| url | https://www.tandfonline.com/doi/10.1080/15476286.2024.2385607 |
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