CNS Depressant and Antiepileptic Activities of the Methanol Extract of the Leaves of Ipomoea Aquatica Forsk
The central nervous system (CNS) depressant and antiepileptic activities of the methanol extract of the leaves of Ipomoea aquatica Forsk (IAF) were investigated on various animal models including pentobarbitone sleeping time and hole-board exploratory behavior for sedation tests and strychnine, picr...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2010/503923 |
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| author | Dhanasekaran Sivaraman Palayan Muralidaran |
| author_facet | Dhanasekaran Sivaraman Palayan Muralidaran |
| author_sort | Dhanasekaran Sivaraman |
| collection | DOAJ |
| description | The central nervous system (CNS) depressant and antiepileptic activities of the methanol extract of the leaves of Ipomoea aquatica Forsk (IAF) were investigated on various animal models including pentobarbitone sleeping time and hole-board exploratory behavior for sedation tests and strychnine, picrotoxin and pentylenetetrazole-induced convulsions in mice. IAF (200 and 400 mg/kg, p.o.), like chlorpromazine HCl (1 mg/kg, i.m.), produced a dose-dependent prolongation of pentobarbitone sleeping time and suppression of exploratory behavior. IAF (200 and 400 mg/kg) produced dose-dependent and significant increases in onset to clonic and tonic convulsions and at 400 mg/kg, showed complete protection against seizures induced by strychnine and picrotoxin but not with pentylenetetrazole. Acute oral toxicity test, up to 14 days, did not produce any visible signs of toxicity. These results suggest that potentially antiepileptic compounds are present in leaf extract of IAF that deserve the study of their identity and mechanism of action. |
| format | Article |
| id | doaj-art-014474c653e54c7fbc63263bc3b4f384 |
| institution | OA Journals |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-014474c653e54c7fbc63263bc3b4f3842025-08-20T02:01:34ZengWileyE-Journal of Chemistry0973-49452090-98102010-01-01741555156110.1155/2010/503923CNS Depressant and Antiepileptic Activities of the Methanol Extract of the Leaves of Ipomoea Aquatica ForskDhanasekaran Sivaraman0Palayan Muralidaran1Department of Pharmacology and Toxicology, C.L. Baid Metha College of Pharmacy, Jyothi Nagar, Thoraipakkam, Chennai-97, Tamilnadu, IndiaDepartment of Pharmacology and Toxicology, C.L. Baid Metha College of Pharmacy, Jyothi Nagar, Thoraipakkam, Chennai-97, Tamilnadu, IndiaThe central nervous system (CNS) depressant and antiepileptic activities of the methanol extract of the leaves of Ipomoea aquatica Forsk (IAF) were investigated on various animal models including pentobarbitone sleeping time and hole-board exploratory behavior for sedation tests and strychnine, picrotoxin and pentylenetetrazole-induced convulsions in mice. IAF (200 and 400 mg/kg, p.o.), like chlorpromazine HCl (1 mg/kg, i.m.), produced a dose-dependent prolongation of pentobarbitone sleeping time and suppression of exploratory behavior. IAF (200 and 400 mg/kg) produced dose-dependent and significant increases in onset to clonic and tonic convulsions and at 400 mg/kg, showed complete protection against seizures induced by strychnine and picrotoxin but not with pentylenetetrazole. Acute oral toxicity test, up to 14 days, did not produce any visible signs of toxicity. These results suggest that potentially antiepileptic compounds are present in leaf extract of IAF that deserve the study of their identity and mechanism of action.http://dx.doi.org/10.1155/2010/503923 |
| spellingShingle | Dhanasekaran Sivaraman Palayan Muralidaran CNS Depressant and Antiepileptic Activities of the Methanol Extract of the Leaves of Ipomoea Aquatica Forsk E-Journal of Chemistry |
| title | CNS Depressant and Antiepileptic Activities of the Methanol Extract of the Leaves of Ipomoea Aquatica Forsk |
| title_full | CNS Depressant and Antiepileptic Activities of the Methanol Extract of the Leaves of Ipomoea Aquatica Forsk |
| title_fullStr | CNS Depressant and Antiepileptic Activities of the Methanol Extract of the Leaves of Ipomoea Aquatica Forsk |
| title_full_unstemmed | CNS Depressant and Antiepileptic Activities of the Methanol Extract of the Leaves of Ipomoea Aquatica Forsk |
| title_short | CNS Depressant and Antiepileptic Activities of the Methanol Extract of the Leaves of Ipomoea Aquatica Forsk |
| title_sort | cns depressant and antiepileptic activities of the methanol extract of the leaves of ipomoea aquatica forsk |
| url | http://dx.doi.org/10.1155/2010/503923 |
| work_keys_str_mv | AT dhanasekaransivaraman cnsdepressantandantiepilepticactivitiesofthemethanolextractoftheleavesofipomoeaaquaticaforsk AT palayanmuralidaran cnsdepressantandantiepilepticactivitiesofthemethanolextractoftheleavesofipomoeaaquaticaforsk |