Protective effects of Salubrinal against H2O2-induced muscle wasting via eIF2α/ATF4 signaling pathway

Protective effects of Salubrinal against H2O2-induced muscle wasting via eIF2α/ATF4 signaling pathway

BackgroundEndoplasmic reticulum stress (ERS) plays a critical role in skeletal muscle physiology and pathology, though the precise mechanisms remain unclear. Salubrinal, a selective inhibitor of eIF2α dephosphorylation, has been shown as a potential therapeutic agent for various conditions, but its...

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Bibliographic Details
Main Authors: Siming Lin, Jingying Wu, Guili Lian, Weibin Wu, Weixiao Chen, Ai Chen, Li Luo, Liangdi Xie
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
sarcopenia
aging
skeletal muscle atrophy
endoplasmic reticulum stress
salubrinal
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1607606/full
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