Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study

Human Lipoxygenase Pathway Gene Variation and Association with Markers of Subclinical Atherosclerosis in the Diabetes Heart Study

Aims. Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds. Methods. Families with two or more siblings with type 2...

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Main Authors: Kathryn P. Burdon, Megan E. Rudock, Allison B. Lehtinen, Carl D. Langefeld, Donald W. Bowden, Thomas C. Register, Yongmei Liu, Barry I. Freedman, J. Jeffrey Carr, Catherine C. Hedrick, Stephen S. Rich
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2010/170153
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