Mechanism of and Therapeutic Strategy for Atrial Fibrillation Associated with Diabetes Mellitus
Diabetes mellitus (DM) is one of the most important risk factors for atrial fibrillation (AF) and is a predictor of stroke and thromboembolism. DM may increase the incidence of AF, and when it is combined with other risk factors, the incidence of stroke and thromboembolism may also be higher; furthe...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/209428 |
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| author | Yubi Lin Hairui Li Xianwu Lan Xianghui Chen Aidong Zhang Zicheng Li |
| author_facet | Yubi Lin Hairui Li Xianwu Lan Xianghui Chen Aidong Zhang Zicheng Li |
| author_sort | Yubi Lin |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is one of the most important risk factors for atrial fibrillation (AF) and is a predictor of stroke and thromboembolism. DM may increase the incidence of AF, and when it is combined with other risk factors, the incidence of stroke and thromboembolism may also be higher; furthermore, hospitalization due to heart failure appears to increase. Maintenance of well-controlled blood glucose and low levels of HbA1c in accordance with guidelines may decrease the incidence of AF. The mechanisms of AF associated with DM are autonomic remodeling, electrical remodeling, structural remodeling, and insulin resistance. Inhibition of the renin-angiotensin system is suggested to be an upstream therapy for this type of AF. Studies have indicated that catheter ablation may be effective for AF associated with DM, restoring sinus rhythm and improving prognosis. Catheter ablation combined with hypoglycemic agents may further increase the rate of maintenance of sinus rhythm and reduce the need for reablation. |
| format | Article |
| id | doaj-art-0138fa650b2746f8a344a7ed5ad6b76e |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-0138fa650b2746f8a344a7ed5ad6b76e2025-08-20T02:01:34ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/209428209428Mechanism of and Therapeutic Strategy for Atrial Fibrillation Associated with Diabetes MellitusYubi Lin0Hairui Li1Xianwu Lan2Xianghui Chen3Aidong Zhang4Zicheng Li5Department of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou 0086-510630, ChinaDepartment of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou 0086-510630, ChinaDepartment of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou 0086-510630, ChinaDepartment of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou 0086-510630, ChinaDepartment of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou 0086-510630, ChinaDepartment of Cardiology, The First Affiliated Hospital of Jinan University, Guangzhou 0086-510630, ChinaDiabetes mellitus (DM) is one of the most important risk factors for atrial fibrillation (AF) and is a predictor of stroke and thromboembolism. DM may increase the incidence of AF, and when it is combined with other risk factors, the incidence of stroke and thromboembolism may also be higher; furthermore, hospitalization due to heart failure appears to increase. Maintenance of well-controlled blood glucose and low levels of HbA1c in accordance with guidelines may decrease the incidence of AF. The mechanisms of AF associated with DM are autonomic remodeling, electrical remodeling, structural remodeling, and insulin resistance. Inhibition of the renin-angiotensin system is suggested to be an upstream therapy for this type of AF. Studies have indicated that catheter ablation may be effective for AF associated with DM, restoring sinus rhythm and improving prognosis. Catheter ablation combined with hypoglycemic agents may further increase the rate of maintenance of sinus rhythm and reduce the need for reablation.http://dx.doi.org/10.1155/2013/209428 |
| spellingShingle | Yubi Lin Hairui Li Xianwu Lan Xianghui Chen Aidong Zhang Zicheng Li Mechanism of and Therapeutic Strategy for Atrial Fibrillation Associated with Diabetes Mellitus The Scientific World Journal |
| title | Mechanism of and Therapeutic Strategy for Atrial Fibrillation Associated with Diabetes Mellitus |
| title_full | Mechanism of and Therapeutic Strategy for Atrial Fibrillation Associated with Diabetes Mellitus |
| title_fullStr | Mechanism of and Therapeutic Strategy for Atrial Fibrillation Associated with Diabetes Mellitus |
| title_full_unstemmed | Mechanism of and Therapeutic Strategy for Atrial Fibrillation Associated with Diabetes Mellitus |
| title_short | Mechanism of and Therapeutic Strategy for Atrial Fibrillation Associated with Diabetes Mellitus |
| title_sort | mechanism of and therapeutic strategy for atrial fibrillation associated with diabetes mellitus |
| url | http://dx.doi.org/10.1155/2013/209428 |
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