Diagnostic and Prognostic Significance of Exosomes and Their Components in Patients With Cancers
ABSTRACT Background Cancer is the second leading cause of human mortality worldwide. Extracellular vesicles (EVs) from liquid biopsy samples are used in early cancer detection, characterization, and surveillance. Exosomes are a subset of EVs produced by all cells and present in all body fluids. They...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.70569 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841543386082836480 |
|---|---|
| author | Zinnat Ara Moni Zahid Hasan Md. Shaheen Alam Nitai Roy Farhadul Islam |
| author_facet | Zinnat Ara Moni Zahid Hasan Md. Shaheen Alam Nitai Roy Farhadul Islam |
| author_sort | Zinnat Ara Moni |
| collection | DOAJ |
| description | ABSTRACT Background Cancer is the second leading cause of human mortality worldwide. Extracellular vesicles (EVs) from liquid biopsy samples are used in early cancer detection, characterization, and surveillance. Exosomes are a subset of EVs produced by all cells and present in all body fluids. They play an important role in the development of cancer because they are active transporters capable of carrying the contents of any type of cell. The objective of this review was to provide a brief overview of the clinical implication of exosomes or exosomal components in cancer diagnosis and prognosis. Methods An extensive review of the current literature of exosomes and their components in cancer diagnosis and prognosis were carried out in the current study. Results Tumor cells release exosomes that contribute to the formation of the pre‐metastatic microenvironment, angiogenesis, invasion, and treatment resistance. On the contrary, tumor cells release more exosomes than normal cells, and these tumor‐specific exosomes can carry the genomic and proteomic signature contents of the tumor cells, which can act as tools for the diagnosis and prognosis of patients with cancers. Conclusion This information may help clinicians to improve the management of cancer patients in clinical settings in the future. |
| format | Article |
| id | doaj-art-01389115c31e4d4bba3f1f19d9b126bf |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-01389115c31e4d4bba3f1f19d9b126bf2025-01-13T13:22:39ZengWileyCancer Medicine2045-76342025-01-01141n/an/a10.1002/cam4.70569Diagnostic and Prognostic Significance of Exosomes and Their Components in Patients With CancersZinnat Ara Moni0Zahid Hasan1Md. Shaheen Alam2Nitai Roy3Farhadul Islam4Department of Biochemistry and Molecular Biology University of Rajshahi Rajshahi BangladeshDepartment of Biochemistry and Molecular Biology University of Rajshahi Rajshahi BangladeshDepartment of Biochemistry and Molecular Biology University of Rajshahi Rajshahi BangladeshDepartment of Biochemistry and Molecular Biology Patuakhali Science and Technology University Patuakhali BangladeshDepartment of Biochemistry and Molecular Biology University of Rajshahi Rajshahi BangladeshABSTRACT Background Cancer is the second leading cause of human mortality worldwide. Extracellular vesicles (EVs) from liquid biopsy samples are used in early cancer detection, characterization, and surveillance. Exosomes are a subset of EVs produced by all cells and present in all body fluids. They play an important role in the development of cancer because they are active transporters capable of carrying the contents of any type of cell. The objective of this review was to provide a brief overview of the clinical implication of exosomes or exosomal components in cancer diagnosis and prognosis. Methods An extensive review of the current literature of exosomes and their components in cancer diagnosis and prognosis were carried out in the current study. Results Tumor cells release exosomes that contribute to the formation of the pre‐metastatic microenvironment, angiogenesis, invasion, and treatment resistance. On the contrary, tumor cells release more exosomes than normal cells, and these tumor‐specific exosomes can carry the genomic and proteomic signature contents of the tumor cells, which can act as tools for the diagnosis and prognosis of patients with cancers. Conclusion This information may help clinicians to improve the management of cancer patients in clinical settings in the future.https://doi.org/10.1002/cam4.70569cancer progressiondiagnosis markersexosomessurvival |
| spellingShingle | Zinnat Ara Moni Zahid Hasan Md. Shaheen Alam Nitai Roy Farhadul Islam Diagnostic and Prognostic Significance of Exosomes and Their Components in Patients With Cancers Cancer Medicine cancer progression diagnosis markers exosomes survival |
| title | Diagnostic and Prognostic Significance of Exosomes and Their Components in Patients With Cancers |
| title_full | Diagnostic and Prognostic Significance of Exosomes and Their Components in Patients With Cancers |
| title_fullStr | Diagnostic and Prognostic Significance of Exosomes and Their Components in Patients With Cancers |
| title_full_unstemmed | Diagnostic and Prognostic Significance of Exosomes and Their Components in Patients With Cancers |
| title_short | Diagnostic and Prognostic Significance of Exosomes and Their Components in Patients With Cancers |
| title_sort | diagnostic and prognostic significance of exosomes and their components in patients with cancers |
| topic | cancer progression diagnosis markers exosomes survival |
| url | https://doi.org/10.1002/cam4.70569 |
| work_keys_str_mv | AT zinnataramoni diagnosticandprognosticsignificanceofexosomesandtheircomponentsinpatientswithcancers AT zahidhasan diagnosticandprognosticsignificanceofexosomesandtheircomponentsinpatientswithcancers AT mdshaheenalam diagnosticandprognosticsignificanceofexosomesandtheircomponentsinpatientswithcancers AT nitairoy diagnosticandprognosticsignificanceofexosomesandtheircomponentsinpatientswithcancers AT farhadulislam diagnosticandprognosticsignificanceofexosomesandtheircomponentsinpatientswithcancers |