All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III
Mortality risk across metabolic health-by-BMI categories in NHANES-III was examined. Metabolic health was defined as: (1) homeostasis model assessment-insulin resistance (HOMA-IR) <2.5; (2) ≤2 Adult Treatment Panel (ATP) III metabolic syndrome criteria; (3) combined definition using ≤1 of the fol...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2012/460321 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832553306210172928 |
|---|---|
| author | C. M. Durward T. J. Hartman S. M. Nickols-Richardson |
| author_facet | C. M. Durward T. J. Hartman S. M. Nickols-Richardson |
| author_sort | C. M. Durward |
| collection | DOAJ |
| description | Mortality risk across metabolic health-by-BMI categories in NHANES-III was examined. Metabolic health was defined as: (1) homeostasis model assessment-insulin resistance (HOMA-IR) <2.5; (2) ≤2 Adult Treatment Panel (ATP) III metabolic syndrome criteria; (3) combined definition using ≤1 of the following: HOMA-IR ≥1.95 (or diabetes medications), triglycerides ≥1.7 mmol/L, HDL-C <1.04 mmol/L (males) or <1.30 mmol/L (females), LDL-C ≥2.6 mmol/L, and total cholesterol ≥5.2 mmol/L (or cholesterol-lowering medications). Hazard ratios (HR) for all-cause mortality were estimated with Cox regression models. Nonpregnant women and men were included (n=4373, mean ± SD, age 37.1±10.9 years, BMI 27.3±5.8 kg/m2, 49.4% female). Only 40 of 1160 obese individuals were identified as MHO by all definitions. MHO groups had superior levels of clinical risk factors compared to unhealthy individuals but inferior levels compared to healthy lean groups. There was increased risk of all-cause mortality in metabolically unhealthy obese participants regardless of definition (HOMA-IR HR 2.07 (CI 1.3–3.4), P<0.01; ATP-III HR 1.98 (CI 1.4–2.9), P<0.001; combined definition HR 2.19 (CI 1.3–3.8), P<0.01). MHO participants were not significantly different from healthy lean individuals by any definition. While MHO individuals are not at significantly increased risk of all-cause mortality, their clinical risk profile is worse than that of metabolically healthy lean individuals. |
| format | Article |
| id | doaj-art-013771b5c2cb4f3c82f1df083548240b |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-013771b5c2cb4f3c82f1df083548240b2025-02-03T05:54:13ZengWileyJournal of Obesity2090-07082090-07162012-01-01201210.1155/2012/460321460321All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES IIIC. M. Durward0T. J. Hartman1S. M. Nickols-Richardson2Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Building, University Park, PA 16801, USADepartment of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Building, University Park, PA 16801, USADepartment of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Building, University Park, PA 16801, USAMortality risk across metabolic health-by-BMI categories in NHANES-III was examined. Metabolic health was defined as: (1) homeostasis model assessment-insulin resistance (HOMA-IR) <2.5; (2) ≤2 Adult Treatment Panel (ATP) III metabolic syndrome criteria; (3) combined definition using ≤1 of the following: HOMA-IR ≥1.95 (or diabetes medications), triglycerides ≥1.7 mmol/L, HDL-C <1.04 mmol/L (males) or <1.30 mmol/L (females), LDL-C ≥2.6 mmol/L, and total cholesterol ≥5.2 mmol/L (or cholesterol-lowering medications). Hazard ratios (HR) for all-cause mortality were estimated with Cox regression models. Nonpregnant women and men were included (n=4373, mean ± SD, age 37.1±10.9 years, BMI 27.3±5.8 kg/m2, 49.4% female). Only 40 of 1160 obese individuals were identified as MHO by all definitions. MHO groups had superior levels of clinical risk factors compared to unhealthy individuals but inferior levels compared to healthy lean groups. There was increased risk of all-cause mortality in metabolically unhealthy obese participants regardless of definition (HOMA-IR HR 2.07 (CI 1.3–3.4), P<0.01; ATP-III HR 1.98 (CI 1.4–2.9), P<0.001; combined definition HR 2.19 (CI 1.3–3.8), P<0.01). MHO participants were not significantly different from healthy lean individuals by any definition. While MHO individuals are not at significantly increased risk of all-cause mortality, their clinical risk profile is worse than that of metabolically healthy lean individuals.http://dx.doi.org/10.1155/2012/460321 |
| spellingShingle | C. M. Durward T. J. Hartman S. M. Nickols-Richardson All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III Journal of Obesity |
| title | All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III |
| title_full | All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III |
| title_fullStr | All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III |
| title_full_unstemmed | All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III |
| title_short | All-Cause Mortality Risk of Metabolically Healthy Obese Individuals in NHANES III |
| title_sort | all cause mortality risk of metabolically healthy obese individuals in nhanes iii |
| url | http://dx.doi.org/10.1155/2012/460321 |
| work_keys_str_mv | AT cmdurward allcausemortalityriskofmetabolicallyhealthyobeseindividualsinnhanesiii AT tjhartman allcausemortalityriskofmetabolicallyhealthyobeseindividualsinnhanesiii AT smnickolsrichardson allcausemortalityriskofmetabolicallyhealthyobeseindividualsinnhanesiii |