Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program.
<h4>Background</h4>The All of Us Research Program enrolls diverse US participants which provide a unique opportunity to better understand the problem of opioid use. This study aims to estimate the prevalence of opioid use and its association with sociodemographic characteristics from sur...
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Public Library of Science (PLoS)
2023-01-01
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| author | Hsueh-Han Yeh Cathryn Peltz-Rauchman Christine C Johnson Pamala A Pawloski David Chesla Stephen C Waring Alan B Stevens Mara Epstein Christine Joseph Lisa R Miller-Matero Hongsheng Gui Amy Tang Eric Boerwinkle Mine Cicek Cheryl R Clark Elizabeth Cohn Kelly Gebo Roxana Loperena Kelsey Mayo Stephen Mockrin Lucila Ohno-Machado Sheri Schully Andrea H Ramirez Jun Qian Brian K Ahmedani |
| author_facet | Hsueh-Han Yeh Cathryn Peltz-Rauchman Christine C Johnson Pamala A Pawloski David Chesla Stephen C Waring Alan B Stevens Mara Epstein Christine Joseph Lisa R Miller-Matero Hongsheng Gui Amy Tang Eric Boerwinkle Mine Cicek Cheryl R Clark Elizabeth Cohn Kelly Gebo Roxana Loperena Kelsey Mayo Stephen Mockrin Lucila Ohno-Machado Sheri Schully Andrea H Ramirez Jun Qian Brian K Ahmedani |
| author_sort | Hsueh-Han Yeh |
| collection | DOAJ |
| description | <h4>Background</h4>The All of Us Research Program enrolls diverse US participants which provide a unique opportunity to better understand the problem of opioid use. This study aims to estimate the prevalence of opioid use and its association with sociodemographic characteristics from survey data and electronic health record (EHR).<h4>Methods</h4>A total of 214,206 participants were included in this study who competed survey modules and shared EHR data. Adjusted logistic regressions were used to explore the associations between sociodemographic characteristics and opioid use.<h4>Results</h4>The lifetime prevalence of street opioids was 4%, and the nonmedical use of prescription opioids was 9%. Men had higher odds of lifetime opioid use (aOR: 1.4 to 3.1) but reduced odds of current nonmedical use of prescription opioids (aOR: 0.6). Participants from other racial and ethnic groups were at reduced odds of lifetime use (aOR: 0.2 to 0.9) but increased odds of current use (aOR: 1.9 to 9.9) compared with non-Hispanic White participants. Foreign-born participants were at reduced risks of opioid use and diagnosed with opioid use disorders (OUD) compared with US-born participants (aOR: 0.36 to 0.67). Men, Younger, White, and US-born participants are more likely to have OUD.<h4>Conclusions</h4>All of Us research data can be used as an indicator of national trends for monitoring the prevalence of receiving prescription opioids, diagnosis of OUD, and non-medical use of opioids in the US. The program employs a longitudinal design for routinely collecting health-related data including EHR data, that will contribute to the literature by providing important clinical information related to opioids over time. Additionally, this data will enhance the estimates of the prevalence of OUD among diverse populations, including groups that are underrepresented in the national survey data. |
| format | Article |
| id | doaj-art-01376c75e08b4505a70db34e6508b409 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-01376c75e08b4505a70db34e6508b4092025-08-20T03:50:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01188e029041610.1371/journal.pone.0290416Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program.Hsueh-Han YehCathryn Peltz-RauchmanChristine C JohnsonPamala A PawloskiDavid CheslaStephen C WaringAlan B StevensMara EpsteinChristine JosephLisa R Miller-MateroHongsheng GuiAmy TangEric BoerwinkleMine CicekCheryl R ClarkElizabeth CohnKelly GeboRoxana LoperenaKelsey MayoStephen MockrinLucila Ohno-MachadoSheri SchullyAndrea H RamirezJun QianBrian K Ahmedani<h4>Background</h4>The All of Us Research Program enrolls diverse US participants which provide a unique opportunity to better understand the problem of opioid use. This study aims to estimate the prevalence of opioid use and its association with sociodemographic characteristics from survey data and electronic health record (EHR).<h4>Methods</h4>A total of 214,206 participants were included in this study who competed survey modules and shared EHR data. Adjusted logistic regressions were used to explore the associations between sociodemographic characteristics and opioid use.<h4>Results</h4>The lifetime prevalence of street opioids was 4%, and the nonmedical use of prescription opioids was 9%. Men had higher odds of lifetime opioid use (aOR: 1.4 to 3.1) but reduced odds of current nonmedical use of prescription opioids (aOR: 0.6). Participants from other racial and ethnic groups were at reduced odds of lifetime use (aOR: 0.2 to 0.9) but increased odds of current use (aOR: 1.9 to 9.9) compared with non-Hispanic White participants. Foreign-born participants were at reduced risks of opioid use and diagnosed with opioid use disorders (OUD) compared with US-born participants (aOR: 0.36 to 0.67). Men, Younger, White, and US-born participants are more likely to have OUD.<h4>Conclusions</h4>All of Us research data can be used as an indicator of national trends for monitoring the prevalence of receiving prescription opioids, diagnosis of OUD, and non-medical use of opioids in the US. The program employs a longitudinal design for routinely collecting health-related data including EHR data, that will contribute to the literature by providing important clinical information related to opioids over time. Additionally, this data will enhance the estimates of the prevalence of OUD among diverse populations, including groups that are underrepresented in the national survey data.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290416&type=printable |
| spellingShingle | Hsueh-Han Yeh Cathryn Peltz-Rauchman Christine C Johnson Pamala A Pawloski David Chesla Stephen C Waring Alan B Stevens Mara Epstein Christine Joseph Lisa R Miller-Matero Hongsheng Gui Amy Tang Eric Boerwinkle Mine Cicek Cheryl R Clark Elizabeth Cohn Kelly Gebo Roxana Loperena Kelsey Mayo Stephen Mockrin Lucila Ohno-Machado Sheri Schully Andrea H Ramirez Jun Qian Brian K Ahmedani Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program. PLoS ONE |
| title | Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program. |
| title_full | Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program. |
| title_fullStr | Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program. |
| title_full_unstemmed | Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program. |
| title_short | Examining sociodemographic correlates of opioid use, misuse, and use disorders in the All of Us Research Program. |
| title_sort | examining sociodemographic correlates of opioid use misuse and use disorders in the all of us research program |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290416&type=printable |
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