Plastic but not progressive changes in cognitive function and hippocampal volume in an adolescent with bipolar disorder: a case report
Bipolar disorder (BD) is a prevalent mood disorder characterized by alternating episodes of depression and mania, often accompanied by varying degrees of cognitive impairment. Cognitive impairments often serve as indicators of a bleak prognosis or the likelihood of progressing to dementia. Additiona...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1507333/full |
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| author | Bo Liu Bo Liu Hui Sun Hui Sun Hui Sun Qiannan Zhao Qiannan Zhao Qiannan Zhao Li Li Rong Tian Su Lui Su Lui Su Lui Hongru Zhu |
| author_facet | Bo Liu Bo Liu Hui Sun Hui Sun Hui Sun Qiannan Zhao Qiannan Zhao Qiannan Zhao Li Li Rong Tian Su Lui Su Lui Su Lui Hongru Zhu |
| author_sort | Bo Liu |
| collection | DOAJ |
| description | Bipolar disorder (BD) is a prevalent mood disorder characterized by alternating episodes of depression and mania, often accompanied by varying degrees of cognitive impairment. Cognitive impairments often serve as indicators of a bleak prognosis or the likelihood of progressing to dementia. Additionally, some studies suggest that individuals diagnosed with BD may undergo a decline in hippocampal volume. However, the potential for reversibility of these changes, particularly in adolescents, remains unclear. We present an intriguing case involving an 18-year-old male student who experiences concurrent occurrences of both BD and mild cognitive impairment (MCI), accompanied by a subtle reduction in hippocampal volume. Initially, the individual exhibited impaired general cognitive function, as indicated by an IQ score of 80 on the Standard Raven’s Progressive Matrices test, and demonstrated slightly reduced bilateral hippocampal volume compared to the normative reference, as determined through quantitative structural magnetic resonance imaging (qsMRI). The deposition profiles of amyloid beta (Aβ) peptide in the brain were not identified with 18F-AV45 PET/MRI. Following six months of combined psychopharmacological treatment and cognitive behavioral therapy, the individual’s psychopathological symptoms improved significantly, leading to a restoration of his IQ score to 116 and normalization of hippocampal volume. This case suggests that the hippocampal volume reduction and cognitive impairment seen in some adolescents with BD may demonstrate greater plasticity compared to neurodegenerative conditions such as Alzheimer’s disease (AD). These findings highlight the potential importance of early intervention in young BD patients with cognitive impairments. |
| format | Article |
| id | doaj-art-01374e93179b4a48b8687814533b1287 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-01374e93179b4a48b8687814533b12872025-01-07T06:47:03ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-01-011510.3389/fpsyt.2024.15073331507333Plastic but not progressive changes in cognitive function and hippocampal volume in an adolescent with bipolar disorder: a case reportBo Liu0Bo Liu1Hui Sun2Hui Sun3Hui Sun4Qiannan Zhao5Qiannan Zhao6Qiannan Zhao7Li Li8Rong Tian9Su Lui10Su Lui11Su Lui12Hongru Zhu13Mental Health Center, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Psychosomatic Medicine, Zigong Mental Health Center, Zigong, ChinaDepartment of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, ChinaHuaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, ChinaResearch Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, ChinaDepartment of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, ChinaHuaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, ChinaResearch Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, ChinaDepartment of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, ChinaHuaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, ChinaResearch Unit of Psychoradiology, Chinese Academy of Medical Sciences, Chengdu, ChinaMental Health Center, West China Hospital, Sichuan University, Chengdu, ChinaBipolar disorder (BD) is a prevalent mood disorder characterized by alternating episodes of depression and mania, often accompanied by varying degrees of cognitive impairment. Cognitive impairments often serve as indicators of a bleak prognosis or the likelihood of progressing to dementia. Additionally, some studies suggest that individuals diagnosed with BD may undergo a decline in hippocampal volume. However, the potential for reversibility of these changes, particularly in adolescents, remains unclear. We present an intriguing case involving an 18-year-old male student who experiences concurrent occurrences of both BD and mild cognitive impairment (MCI), accompanied by a subtle reduction in hippocampal volume. Initially, the individual exhibited impaired general cognitive function, as indicated by an IQ score of 80 on the Standard Raven’s Progressive Matrices test, and demonstrated slightly reduced bilateral hippocampal volume compared to the normative reference, as determined through quantitative structural magnetic resonance imaging (qsMRI). The deposition profiles of amyloid beta (Aβ) peptide in the brain were not identified with 18F-AV45 PET/MRI. Following six months of combined psychopharmacological treatment and cognitive behavioral therapy, the individual’s psychopathological symptoms improved significantly, leading to a restoration of his IQ score to 116 and normalization of hippocampal volume. This case suggests that the hippocampal volume reduction and cognitive impairment seen in some adolescents with BD may demonstrate greater plasticity compared to neurodegenerative conditions such as Alzheimer’s disease (AD). These findings highlight the potential importance of early intervention in young BD patients with cognitive impairments.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1507333/fullbipolar disordercognitive functionhippocampal volumeadolescentcase reportplasticity |
| spellingShingle | Bo Liu Bo Liu Hui Sun Hui Sun Hui Sun Qiannan Zhao Qiannan Zhao Qiannan Zhao Li Li Rong Tian Su Lui Su Lui Su Lui Hongru Zhu Plastic but not progressive changes in cognitive function and hippocampal volume in an adolescent with bipolar disorder: a case report Frontiers in Psychiatry bipolar disorder cognitive function hippocampal volume adolescent case report plasticity |
| title | Plastic but not progressive changes in cognitive function and hippocampal volume in an adolescent with bipolar disorder: a case report |
| title_full | Plastic but not progressive changes in cognitive function and hippocampal volume in an adolescent with bipolar disorder: a case report |
| title_fullStr | Plastic but not progressive changes in cognitive function and hippocampal volume in an adolescent with bipolar disorder: a case report |
| title_full_unstemmed | Plastic but not progressive changes in cognitive function and hippocampal volume in an adolescent with bipolar disorder: a case report |
| title_short | Plastic but not progressive changes in cognitive function and hippocampal volume in an adolescent with bipolar disorder: a case report |
| title_sort | plastic but not progressive changes in cognitive function and hippocampal volume in an adolescent with bipolar disorder a case report |
| topic | bipolar disorder cognitive function hippocampal volume adolescent case report plasticity |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1507333/full |
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