Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases

Ferroptosis is a new type of iron-dependent cell death caused by lipid peroxide (LPO) accumulation and involved in disease of pulmonary infection. The dysregulation of iron metabolism, the accumulation of LPO, and the inactivation and consumption of glutathione peroxidase 4 (GPX4) are the crucial ca...

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Main Authors: Yurong Zhang, Dianlun Qian, Xiangfeng Bai, Shibo Sun
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Cellular Microbiology
Online Access:http://dx.doi.org/10.1155/2023/3875897
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author Yurong Zhang
Dianlun Qian
Xiangfeng Bai
Shibo Sun
author_facet Yurong Zhang
Dianlun Qian
Xiangfeng Bai
Shibo Sun
author_sort Yurong Zhang
collection DOAJ
description Ferroptosis is a new type of iron-dependent cell death caused by lipid peroxide (LPO) accumulation and involved in disease of pulmonary infection. The dysregulation of iron metabolism, the accumulation of LPO, and the inactivation and consumption of glutathione peroxidase 4 (GPX4) are the crucial cause of ferroptosis. Pulmonary infectious diseases caused by Pseudomonas aeruginosa (PA), Mycobacterium tuberculosis (MTB), and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are associated with ferroptosis. Ferroptosis may be a potential therapeutic target for pulmonary infectious diseases. However, the mechanisms by which these infections are involved in ferroptosis and whether pulmonary infectious diseases caused by Staphylococcus aureus, Klebsiella pneumoniae, and Leishmania spp are related to ferroptosis are unclear. Accordingly, more researches are needed.
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institution Kabale University
issn 1462-5822
language English
publishDate 2023-01-01
publisher Wiley
record_format Article
series Cellular Microbiology
spelling doaj-art-012a97379b59488ab9a8870f88eadf8e2025-02-03T01:29:28ZengWileyCellular Microbiology1462-58222023-01-01202310.1155/2023/3875897Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious DiseasesYurong Zhang0Dianlun Qian1Xiangfeng Bai2Shibo Sun3Department of Pulmonary and Critical Care MedicineDepartment of CardiologyDepartment of CardiologyDepartment of Pulmonary and Critical Care MedicineFerroptosis is a new type of iron-dependent cell death caused by lipid peroxide (LPO) accumulation and involved in disease of pulmonary infection. The dysregulation of iron metabolism, the accumulation of LPO, and the inactivation and consumption of glutathione peroxidase 4 (GPX4) are the crucial cause of ferroptosis. Pulmonary infectious diseases caused by Pseudomonas aeruginosa (PA), Mycobacterium tuberculosis (MTB), and severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are associated with ferroptosis. Ferroptosis may be a potential therapeutic target for pulmonary infectious diseases. However, the mechanisms by which these infections are involved in ferroptosis and whether pulmonary infectious diseases caused by Staphylococcus aureus, Klebsiella pneumoniae, and Leishmania spp are related to ferroptosis are unclear. Accordingly, more researches are needed.http://dx.doi.org/10.1155/2023/3875897
spellingShingle Yurong Zhang
Dianlun Qian
Xiangfeng Bai
Shibo Sun
Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases
Cellular Microbiology
title Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases
title_full Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases
title_fullStr Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases
title_full_unstemmed Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases
title_short Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases
title_sort ferroptosis is a potential therapeutic target for pulmonary infectious diseases
url http://dx.doi.org/10.1155/2023/3875897
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AT dianlunqian ferroptosisisapotentialtherapeutictargetforpulmonaryinfectiousdiseases
AT xiangfengbai ferroptosisisapotentialtherapeutictargetforpulmonaryinfectiousdiseases
AT shibosun ferroptosisisapotentialtherapeutictargetforpulmonaryinfectiousdiseases